STRINGSTRING
LOC108300898 LOC108300898 FOXJ2 FOXJ2 MDM2 MDM2 PLK2 PLK2 HOMER2 HOMER2 STK11 STK11 LDLRAD4 LDLRAD4 ENSCCAP00000003376 ENSCCAP00000003376 PRKAG1 PRKAG1 MYO9A MYO9A S1PR4 S1PR4 TSSK2 TSSK2 TSSK6 TSSK6 LOC108300424 LOC108300424 FOXG1 FOXG1 S1PR1 S1PR1 RAG1 RAG1 ENSCCAP00000005016 ENSCCAP00000005016 MAP2K2 MAP2K2 PLK3 PLK3 RASGEF1A RASGEF1A GABARAPL2 GABARAPL2 SMAD3 SMAD3 SGK3 SGK3 CDK3 CDK3 PIK3R1 PIK3R1 MAPK10 MAPK10 PRKAB1 PRKAB1 PTEN PTEN PIK3CD PIK3CD IRS2 IRS2 ATG12 ATG12 TGFBR2 TGFBR2 CCNB2 CCNB2 BCL2L11 BCL2L11 IKBKB IKBKB ENSCCAP00000010305 ENSCCAP00000010305 AKT3 AKT3 RAF1 RAF1 FBXO32 FBXO32 INSR INSR BCL6B BCL6B IL6 IL6 GADD45B GADD45B SOS2 SOS2 EGFR EGFR CDKN2B CDKN2B PIK3R3 PIK3R3 LOC108282680 LOC108282680 CCNG2 CCNG2 TGFB3 TGFB3 SUCO SUCO NLK NLK MYO9B MYO9B HOMER3 HOMER3 SNAPIN SNAPIN CDKN1A CDKN1A MAPK1 MAPK1 GRAP GRAP SOD2 SOD2 CREBBP CREBBP SOS1 SOS1 GABARAP GABARAP KLF2 KLF2 MAPK13 MAPK13 BCL6 BCL6 ENSCCAP00000017664 ENSCCAP00000017664 STK4 STK4 STAT3 STAT3 G6PC2 G6PC2 CNTD2 CNTD2 TGFB2 TGFB2 PCK2 PCK2 G6PC3 G6PC3 PMEPA1 PMEPA1 PLK1 PLK1 AKT2 AKT2 PLK5 PLK5 CDK2 CDK2 PIK3CA PIK3CA CCND1 CCND1 ENSCCAP00000021207 ENSCCAP00000021207 GRM1 GRM1 ATM ATM PIK3CB PIK3CB PRKAA1 PRKAA1 CCNB1 CCNB1 INS INS SKP2 SKP2 SIRT1 SIRT1 PRKAG2 PRKAG2 SGK2 SGK2 AGAP2 AGAP2 IGF1R IGF1R REM1 REM1 SETD7 SETD7 NRAS NRAS ENSCCAP00000026158 ENSCCAP00000026158 FOXO3 FOXO3 TGFB1 TGFB1 HOMER1 HOMER1 MAPK14 MAPK14 BRAF BRAF GABARAPL1 GABARAPL1 TSSK4 TSSK4 IL7R IL7R SLC35E3 SLC35E3 HRAS HRAS MAPK12 MAPK12 GRB2 GRB2 CDKN2D CDKN2D KRAS KRAS CCND2 CCND2 SLC2A4 SLC2A4 TNFSF10 TNFSF10 CAT CAT PRKAG3 PRKAG3 TGFBR1 TGFBR1 SMAD4 SMAD4 G6PC G6PC CHUK CHUK PRMT8 PRMT8 ENSCCAP00000031241 ENSCCAP00000031241 SGK1 SGK1 IRS4 IRS4 FOXJ3 FOXJ3 BNIP3 BNIP3 LOC108289508 LOC108289508 PRMT3 PRMT3 ENSCCAP00000033234 ENSCCAP00000033234 REM2 REM2 AKT1 AKT1 ENSCCAP00000034704 ENSCCAP00000034704 MAPK8 MAPK8 PRKAA2 PRKAA2 TSSK1B TSSK1B IL10 IL10 PRKAB2 PRKAB2 GADD45G GADD45G RRAD RRAD RBL2 RBL2 FOXO4 FOXO4 ARAF ARAF TSSK3 TSSK3 PRMT1 PRMT1 GEM GEM CDKN1B CDKN1B RNF111 RNF111 PCK1 PCK1 PIK3R2 PIK3R2 IGF1 IGF1 FASLG FASLG MAPK3 MAPK3 LOC108313878 LOC108313878 ENSCCAP00000037716 ENSCCAP00000037716 FBXO25 FBXO25 EP300 EP300 CSDE1 CSDE1 EGF EGF USP7 USP7 FOXO1 FOXO1 PDPK1 PDPK1 RNF6 RNF6 GADD45A GADD45A FOXO6 FOXO6 RASL11B RASL11B MAPK9 MAPK9 MAPK11 MAPK11 RASGEF1B RASGEF1B RAG2 RAG2 TMEM232 TMEM232 LOC108304329 LOC108304329
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108300898Protein kinase domain-containing protein. (271 aa)
FOXJ2Forkhead box J2. (569 aa)
MDM2Uncharacterized protein. (499 aa)
PLK2Polo like kinase 2. (566 aa)
HOMER2Homer scaffold protein 2. (351 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
ENSCCAP00000003376Protein kinase domain-containing protein. (184 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2548 aa)
S1PR4Sphingosine-1-phosphate receptor 4. (384 aa)
TSSK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (358 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
LOC108300424Testis-specific serine/threonine-protein kinase 2. (358 aa)
FOXG1Forkhead box G1. (490 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
ENSCCAP00000005016Protein kinase domain-containing protein. (109 aa)
MAP2K2Mitogen-activated protein kinase kinase 2. (303 aa)
PLK3Serine/threonine-protein kinase PLK. (668 aa)
RASGEF1ARasGEF domain family member 1A. (489 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (487 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MAPK10Mitogen-activated protein kinase. (538 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1056 aa)
IRS2Insulin receptor substrate 2. (1361 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
BCL2L11BCL2 like 11. (200 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
ENSCCAP00000010305Uncharacterized protein. (181 aa)
AKT3AKT serine/threonine kinase 3. (472 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
FBXO32F-box protein 32. (355 aa)
INSRTyrosine-protein kinase receptor. (1352 aa)
BCL6BBCL6B transcription repressor. (477 aa)
IL6Interleukin 6. (212 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (175 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
PIK3R3Uncharacterized protein. (577 aa)
LOC108282680Protein kinase domain-containing protein. (245 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (344 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SUCOSUN domain containing ossification factor. (1366 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2155 aa)
HOMER3WH1 domain-containing protein. (361 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (158 aa)
MAPK1Mitogen-activated protein kinase. (366 aa)
GRAPGRB2 related adaptor protein. (217 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
CREBBPCREB binding protein. (2448 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1329 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
KLF2Kruppel like factor 2. (354 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
BCL6BCL6 transcription repressor. (706 aa)
ENSCCAP00000017664Uncharacterized protein. (235 aa)
STK4Serine/threonine kinase 4. (487 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
CNTD2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (305 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (287 aa)
PLK1Serine/threonine-protein kinase PLK. (602 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PLK5Polo like kinase 5. (336 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ENSCCAP00000021207Uncharacterized protein. (348 aa)
GRM1Glutamate metabotropic receptor 1. (1194 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3000 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CCNB1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (368 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
SKP2F-box domain-containing protein. (424 aa)
SIRT1Sirtuin 1. (446 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (409 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa)
IGF1RTyrosine-protein kinase receptor. (1285 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
NRASUncharacterized protein. (189 aa)
ENSCCAP00000026158CSD_1 domain-containing protein. (440 aa)
FOXO3Forkhead box O3. (672 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (314 aa)
HOMER1Homer scaffold protein 1. (357 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
TSSK4Testis specific serine kinase 4. (339 aa)
IL7RInterleukin 7 receptor. (459 aa)
SLC35E3Solute carrier family 35 member E3. (313 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (487 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (496 aa)
SMAD4Mothers against decapentaplegic homolog. (469 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (761 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
ENSCCAP00000031241Uncharacterized protein. (387 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
IRS4Insulin receptor substrate 4. (1253 aa)
FOXJ3Forkhead box J3. (622 aa)
BNIP3BCL2 interacting protein 3. (250 aa)
LOC108289508Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (531 aa)
ENSCCAP00000033234Uncharacterized protein; Belongs to the cyclin family. (277 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
ENSCCAP00000034704SWIB domain-containing protein. (368 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
TSSK1BTestis specific serine kinase 1B; Belongs to the protein kinase superfamily. (366 aa)
IL10Interleukin 10. (178 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (276 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
RBL2RB transcriptional corepressor like 2. (1140 aa)
FOXO4Forkhead box O4. (505 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (354 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (205 aa)
RNF111Ring finger protein 111. (960 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PIK3R2Uncharacterized protein. (727 aa)
IGF1Insulin like growth factor 1. (199 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (281 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LOC108313878Uncharacterized protein. (523 aa)
ENSCCAP00000037716Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (276 aa)
FBXO25F-box protein 25. (367 aa)
EP300E1A binding protein p300. (2420 aa)
CSDE1Uncharacterized protein. (844 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1101 aa)
FOXO1Forkhead box O1. (654 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (562 aa)
RNF6Ring finger protein 6. (685 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
FOXO6Forkhead box O6. (561 aa)
RASL11BRAS like family 11 member B. (248 aa)
MAPK9Mitogen-activated protein kinase. (392 aa)
MAPK11Mitogen-activated protein kinase. (368 aa)
RASGEF1BRasGEF domain family member 1B. (560 aa)
RAG2Recombination activating 2. (527 aa)
TMEM232Transmembrane protein 232. (557 aa)
LOC108304329Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (428 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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