STRINGSTRING
WEE1 WEE1 CDC23 CDC23 CDC7 CDC7 HDAC2 HDAC2 ZBTB17 ZBTB17 RBL2 RBL2 GADD45G GADD45G ANAPC2 ANAPC2 LOC108299868 LOC108299868 ENSCCAP00000034806 ENSCCAP00000034806 ENSCCAP00000034704 ENSCCAP00000034704 CCNA2 CCNA2 BUB3 BUB3 RAD21 RAD21 SMC3 SMC3 ZBTB10 ZBTB10 ENSCCAP00000033921 ENSCCAP00000033921 CDC20B CDC20B ENSCCAP00000033589 ENSCCAP00000033589 ENSCCAP00000033234 ENSCCAP00000033234 MCM5 MCM5 MCM3 MCM3 YWHAE YWHAE ZNF652 ZNF652 YWHAG YWHAG CDKN2A CDKN2A ANAPC5 ANAPC5 ENSCCAP00000031460 ENSCCAP00000031460 SMC1A SMC1A BUB1 BUB1 ORC3 ORC3 CDC20 CDC20 SMAD4 SMAD4 WEE2 WEE2 ENSCCAP00000030012 ENSCCAP00000030012 LOC108297658 LOC108297658 MYC MYC CDK6 CDK6 TP53 TP53 ORC1 ORC1 ANAPC11 ANAPC11 CCND2 CCND2 CDC45 CDC45 CDK4 CDK4 CDK20 CDK20 CCNH CCNH CDKN2D CDKN2D SKP1 SKP1 E2F1 E2F1 YWHAQ YWHAQ CCNA1 CCNA1 FZR1 FZR1 ENSCCAP00000026918 ENSCCAP00000026918 TGFB1 TGFB1 TTK TTK LOC108293639 LOC108293639 MAD2L1 MAD2L1 ORC5 ORC5 ENSCCAP00000024678 ENSCCAP00000024678 CHEK1 CHEK1 CDK7 CDK7 MYNN MYNN FAM126B FAM126B SKP2 SKP2 SMC1B SMC1B YWHAZ YWHAZ STAG1 STAG1 DBF4 DBF4 CDC6 CDC6 HDAC1 HDAC1 PTTG1 PTTG1 ENSCCAP00000040563 ENSCCAP00000040563 ENSCCAP00000036323 ENSCCAP00000036323 CDKN1B CDKN1B PKMYT1 PKMYT1 ZBTB47 ZBTB47 CDC25A CDC25A SMAD2 SMAD2 MAD2L2 MAD2L2 CDC27 CDC27 EP300 EP300 CDC25B CDC25B ANAPC13 ANAPC13 GADD45A GADD45A PCNA PCNA MCM7 MCM7 ENSCCAP00000038982 ENSCCAP00000038982 CDC14A CDC14A RBX1 RBX1 LOC108313247 LOC108313247 ATR ATR ORC2 ORC2 LOC108304329 LOC108304329 E2F4 E2F4 MDM2 MDM2 ORC4 ORC4 ENSCCAP00000001520 ENSCCAP00000001520 ENSCCAP00000001605 ENSCCAP00000001605 ENSCCAP00000002039 ENSCCAP00000002039 STAG2 STAG2 LOC108286105 LOC108286105 MCM2 MCM2 LOC108302722 LOC108302722 SFN SFN TMEM82 TMEM82 RB1 RB1 LOC108296878 LOC108296878 CCNE1 CCNE1 CCNE2 CCNE2 CDKN2C CDKN2C ENSCCAP00000005634 ENSCCAP00000005634 SMAD3 SMAD3 ENSCCAP00000006363 ENSCCAP00000006363 CDK3 CDK3 E2F2 E2F2 ENSCCAP00000006462 ENSCCAP00000006462 ORC6 ORC6 PTTG2 PTTG2 ENSCCAP00000008620 ENSCCAP00000008620 ZBTB46 ZBTB46 ENSCCAP00000009165 ENSCCAP00000009165 ENSCCAP00000009590 ENSCCAP00000009590 CCNB2 CCNB2 CDKN1C CDKN1C YWHAB YWHAB RBL1 RBL1 LOC108299241 LOC108299241 ANAPC10 ANAPC10 CDC25C CDC25C CHEK2 CHEK2 LOC108312562 LOC108312562 CCND3 CCND3 GADD45B GADD45B CDKN2B CDKN2B RAD21L1 RAD21L1 ANAPC4 ANAPC4 ABL1 ABL1 TGFB3 TGFB3 MCM4 MCM4 ANAPC1 ANAPC1 LOC108303723 LOC108303723 SNAPIN SNAPIN ESPL1 ESPL1 CUL1 CUL1 CDKN1A CDKN1A GSK3B GSK3B MCM6 MCM6 ENSCCAP00000015738 ENSCCAP00000015738 ENSCCAP00000015846 ENSCCAP00000015846 CREBBP CREBBP ENSCCAP00000016323 ENSCCAP00000016323 TFDP1 TFDP1 ENSCCAP00000017664 ENSCCAP00000017664 LOC108299127 LOC108299127 BUB1B BUB1B CDC14B CDC14B TFDP2 TFDP2 CNTD2 CNTD2 TGFB2 TGFB2 PLK1 PLK1 LOC108289705 LOC108289705 CDC16 CDC16 E2F3 E2F3 E2F5 E2F5 CDK2 CDK2 CCND1 CCND1 ENSCCAP00000021207 ENSCCAP00000021207 ATM ATM CDK1 CDK1 PRKDC PRKDC LOC108304334 LOC108304334 ANAPC7 ANAPC7 CCNB1 CCNB1 AP5S1 AP5S1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WEE1Wee1-like protein kinase. (553 aa)
CDC23Cell division cycle 23. (597 aa)
CDC7Cell division cycle 7. (575 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
ZBTB17Zinc finger and BTB domain containing 17. (779 aa)
RBL2RB transcriptional corepressor like 2. (1140 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (823 aa)
LOC108299868WD_REPEATS_REGION domain-containing protein. (514 aa)
ENSCCAP00000034806Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (260 aa)
ENSCCAP00000034704SWIB domain-containing protein. (368 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
BUB3BUB3 mitotic checkpoint protein. (424 aa)
RAD21RAD21 cohesin complex component. (605 aa)
SMC3Structural maintenance of chromosomes protein. (1215 aa)
ZBTB10Zinc finger and BTB domain containing 10. (867 aa)
ENSCCAP00000033921Uncharacterized protein; Belongs to the SKP1 family. (162 aa)
CDC20BCell division cycle 20B. (519 aa)
ENSCCAP00000033589DOC domain-containing protein. (195 aa)
ENSCCAP00000033234Uncharacterized protein; Belongs to the cyclin family. (277 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
MCM3DNA helicase; Belongs to the MCM family. (835 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa)
ZNF652Zinc finger protein 652. (606 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
ENSCCAP00000031460Protein kinase domain-containing protein. (272 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1066 aa)
ORC3Origin recognition complex subunit 3. (685 aa)
CDC20WD_REPEATS_REGION domain-containing protein. (380 aa)
SMAD4Mothers against decapentaplegic homolog. (469 aa)
WEE2Wee1-like protein kinase. (564 aa)
ENSCCAP00000030012Protein kinase domain-containing protein. (266 aa)
LOC108297658Uncharacterized protein. (425 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
ANAPC11RING-type domain-containing protein. (84 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
CDC45Cell division cycle 45. (594 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
CDK20Cyclin dependent kinase 20; Belongs to the protein kinase superfamily. (346 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (128 aa)
E2F1E2F transcription factor 1. (438 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (448 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
ENSCCAP00000026918Uncharacterized protein. (262 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (314 aa)
TTKTTK protein kinase. (856 aa)
LOC108293639Uncharacterized protein. (289 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
ENSCCAP00000024678Transcription factor. (362 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
MYNNUncharacterized protein. (610 aa)
FAM126BFamily with sequence similarity 126 member B. (530 aa)
SKP2F-box domain-containing protein. (424 aa)
SMC1BStructural maintenance of chromosomes protein. (1235 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (257 aa)
STAG1Stromal antigen 1. (1267 aa)
DBF4DBF4-type domain-containing protein. (670 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
PTTG1Uncharacterized protein. (144 aa)
ENSCCAP00000040563Uncharacterized protein; Belongs to the SKP1 family. (155 aa)
ENSCCAP00000036323Uncharacterized protein. (499 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (205 aa)
PKMYT1Protein kinase, membrane associated tyrosine/threonine 1. (563 aa)
ZBTB47Zinc finger and BTB domain containing 47. (744 aa)
CDC25ACell division cycle 25A. (479 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (242 aa)
CDC27Cell division cycle 27. (830 aa)
EP300E1A binding protein p300. (2420 aa)
CDC25BCell division cycle 25B. (633 aa)
ANAPC13Uncharacterized protein. (74 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (709 aa)
ENSCCAP00000038982Uncharacterized protein. (128 aa)
CDC14ACell division cycle 14A. (597 aa)
RBX1Ring-box 1. (108 aa)
LOC108313247Protein kinase domain-containing protein. (276 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
LOC108304329Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (428 aa)
E2F4E2F transcription factor 4. (418 aa)
MDM2Uncharacterized protein. (499 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
ENSCCAP0000000152014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
ENSCCAP00000001605Uncharacterized protein; Belongs to the SKP1 family. (164 aa)
ENSCCAP00000002039Uncharacterized protein. (73 aa)
STAG2Stromal antigen 2. (1242 aa)
LOC108286105Uncharacterized protein. (202 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
LOC10830272214_3_3 domain-containing protein; Belongs to the 14-3-3 family. (232 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
TMEM82Transmembrane protein 82. (342 aa)
RB1RB transcriptional corepressor 1. (927 aa)
LOC108296878Uncharacterized protein. (557 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
ENSCCAP00000005634Hist_deacetyl domain-containing protein. (305 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ENSCCAP0000000636314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (108 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
E2F2E2F transcription factor 2. (435 aa)
ENSCCAP00000006462Uncharacterized protein. (343 aa)
ORC6Origin recognition complex subunit 6. (150 aa)
PTTG2Pituitary tumor-transforming 2. (137 aa)
ENSCCAP0000000862014_3_3 domain-containing protein. (104 aa)
ZBTB46Zinc finger and BTB domain containing 46. (588 aa)
ENSCCAP0000000916514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (249 aa)
ENSCCAP00000009590Rad21_Rec8 domain-containing protein. (546 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (301 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
RBL1RB transcriptional corepressor like 1. (1021 aa)
LOC108299241DBF4-type domain-containing protein. (408 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
CDC25CCell division cycle 25C. (459 aa)
CHEK2Checkpoint kinase 2. (589 aa)
LOC108312562Uncharacterized protein. (153 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (175 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
RAD21L1RAD21 cohesin complex component like 1. (556 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
ANAPC1Anaphase promoting complex subunit 1. (1913 aa)
LOC108303723Protein kinase domain-containing protein. (251 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2102 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (158 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (434 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
ENSCCAP00000015738Uncharacterized protein. (199 aa)
ENSCCAP00000015846Uncharacterized protein. (67 aa)
CREBBPCREB binding protein. (2448 aa)
ENSCCAP00000016323Uncharacterized protein. (67 aa)
TFDP1Transcription factor. (411 aa)
ENSCCAP00000017664Uncharacterized protein. (235 aa)
LOC10829912714_3_3 domain-containing protein; Belongs to the 14-3-3 family. (223 aa)
BUB1BBUB1 N-terminal domain-containing protein. (1039 aa)
CDC14BCell division cycle 14B. (498 aa)
TFDP2Transcription factor. (440 aa)
CNTD2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (305 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PLK1Serine/threonine-protein kinase PLK. (602 aa)
LOC108289705Protein kinase domain-containing protein. (221 aa)
CDC16Cell division cycle 16. (620 aa)
E2F3E2F transcription factor 3. (461 aa)
E2F5E2F transcription factor 5. (345 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ENSCCAP00000021207Uncharacterized protein. (348 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3000 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
LOC108304334Protein kinase domain-containing protein. (342 aa)
ANAPC7Anaphase promoting complex subunit 7. (565 aa)
CCNB1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (368 aa)
AP5S1Adaptor related protein complex 5 subunit sigma 1. (200 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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