STRINGSTRING
PFKM PFKM PPP2R3B PPP2R3B PPP2R2A PPP2R2A CREB3L2 CREB3L2 RAB2A RAB2A PPP2CA PPP2CA ULK1 ULK1 ELAVL1 ELAVL1 CPT1A CPT1A PPP2R1A PPP2R1A CREB3 CREB3 PFKFB1 PFKFB1 ACACB ACACB PPARGC1A PPARGC1A PFKFB2 PFKFB2 CREB1 CREB1 ADIPOR2 ADIPOR2 PIK3R3 PIK3R3 PPP2R3C PPP2R3C ADIPOR1 ADIPOR1 INSR INSR HMGCR HMGCR PFKL PFKL AKT3 AKT3 FASN FASN IRS2 IRS2 PPP2R2B PPP2R2B FBP2 FBP2 RHEBL1 RHEBL1 PPP2R5D PPP2R5D PIK3CD PIK3CD PRKAB1 PRKAB1 PIK3R1 PIK3R1 PFKFB3 PFKFB3 CAMKK2 CAMKK2 STRADB STRADB RPS6KB1 RPS6KB1 RAB14 RAB14 ACACA ACACA AKT1S1 AKT1S1 PRKAG1 PRKAG1 SREBF1 SREBF1 ADRA1A ADRA1A STK11 STK11 CREB3L3 CREB3L3 FBP1 FBP1 LOC108318295 LOC108318295 LOC108314991 LOC108314991 PPP2R5C PPP2R5C GAREM2 GAREM2 PPP2R5E PPP2R5E PDPK1 PDPK1 TSC2 TSC2 MLYCD MLYCD FOXO1 FOXO1 IGF1 IGF1 RPTOR RPTOR PIK3R2 PIK3R2 PCK1 PCK1 EIF4EBP1 EIF4EBP1 CREB3L1 CREB3L1 PRKAB2 PRKAB2 PRKAA2 PRKAA2 CCNA2 CCNA2 AKT1 AKT1 EEF2 EEF2 PPP2R3A PPP2R3A IRS4 IRS4 CRTC2 CRTC2 G6PC G6PC SCD5 SCD5 PRKAG3 PRKAG3 SLC2A4 SLC2A4 CD36 CD36 PPP2CB PPP2CB PPP2R2C PPP2R2C LEP LEP RAB10 RAB10 SCD SCD CCNA1 CCNA1 EEF2K EEF2K LIPE LIPE CREB3L4 CREB3L4 ADIPOQ ADIPOQ RAB11B RAB11B PPP2R1B PPP2R1B CPT1B CPT1B FOXO3 FOXO3 RHEB RHEB IGF1R IGF1R TBC1D1 TBC1D1 PRKAG2 PRKAG2 RAB8A RAB8A SIRT1 SIRT1 PPP2R5B PPP2R5B INS INS STRADA STRADA HNF4A HNF4A GYS2 GYS2 CAB39 CAB39 LEPR LEPR PFKFB4 PFKFB4 LOC108294561 LOC108294561 PRKAA1 PRKAA1 CREB5 CREB5 RAB2B RAB2B PIK3CB PIK3CB PFKP PFKP RPS6KB2 RPS6KB2 MTOR MTOR CCND1 CCND1 TSC1 TSC1 PIK3CA PIK3CA PPP2R2D PPP2R2D AKT2 AKT2 PPARG PPARG G6PC3 G6PC3 MAP3K7 MAP3K7 CAB39L CAB39L PPP2R5A PPP2R5A PCK2 PCK2 CFTR CFTR G6PC2 G6PC2 GYS1 GYS1 ENSCCAP00000017896 ENSCCAP00000017896
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (502 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
RAB2ARAB2A, member RAS oncogene family. (216 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ULK1Unc-51 like autophagy activating kinase 1. (964 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
CREB3cAMP responsive element binding protein 3. (374 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (378 aa)
ACACBAcetyl-CoA carboxylase beta. (2458 aa)
PPARGC1APPARG coactivator 1 alpha. (812 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (522 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ADIPOR2Adiponectin receptor 2. (387 aa)
PIK3R3Uncharacterized protein. (577 aa)
PPP2R3CEF-hand_13 domain-containing protein. (453 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
INSRTyrosine-protein kinase receptor. (1352 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (821 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
AKT3AKT serine/threonine kinase 3. (472 aa)
FASNFatty acid synthase. (2541 aa)
IRS2Insulin receptor substrate 2. (1361 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
RHEBL1RHEB like 1. (164 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (600 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1056 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (535 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
STRADBSTE20 related adaptor beta. (403 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
AKT1S1AKT1 substrate 1. (276 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1185 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (415 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
LOC108318295EF-hand_13 domain-containing protein. (468 aa)
LOC108314991Protein kinase domain-containing protein. (363 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (875 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (562 aa)
TSC2TSC complex subunit 2. (1777 aa)
MLYCDMalonyl-CoA decarboxylase. (493 aa)
FOXO1Forkhead box O1. (654 aa)
IGF1Insulin like growth factor 1. (199 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1305 aa)
PIK3R2Uncharacterized protein. (727 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (276 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
EEF2Eukaryotic translation elongation factor 2. (861 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
IRS4Insulin receptor substrate 4. (1253 aa)
CRTC2CREB regulated transcription coactivator 2. (620 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (487 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
CD36CD36 molecule; Belongs to the CD36 family. (476 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
SCDStearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (448 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
LIPELipase E, hormone sensitive type. (1072 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (394 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (604 aa)
CPT1BCarnitine palmitoyltransferase 1B. (774 aa)
FOXO3Forkhead box O3. (672 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
IGF1RTyrosine-protein kinase receptor. (1285 aa)
TBC1D1TBC1 domain family member 1. (1126 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
SIRT1Sirtuin 1. (446 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
STRADAProtein kinase domain-containing protein. (431 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (709 aa)
CAB39Calcium binding protein 39. (341 aa)
LEPRLeptin receptor. (1165 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4. (469 aa)
LOC108294561Uncharacterized protein. (718 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
RAB2BRAB2B, member RAS oncogene family. (178 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (784 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
MTORSerine/threonine-protein kinase mTOR. (2508 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
TSC1TSC complex subunit 1. (1149 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (475 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CAB39LCalcium binding protein 39 like. (337 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
ENSCCAP00000017896SER_THR_PHOSPHATASE domain-containing protein. (233 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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