STRINGSTRING
INSR INSR ADCY7 ADCY7 ADIPOR1 ADIPOR1 KL KL ATF4 ATF4 TSC2 TSC2 FOXO1 FOXO1 CSDE1 CSDE1 LOC108309036 LOC108309036 IGF1 IGF1 RPTOR RPTOR PIK3R2 PIK3R2 EIF4EBP1 EIF4EBP1 CREB3L1 CREB3L1 ATF2 ATF2 EHMT2 EHMT2 PRKAB2 PRKAB2 PRKAA2 PRKAA2 AKT1 AKT1 TBCA TBCA PRKACA PRKACA IRS4 IRS4 ADCY1 ADCY1 PTRHD1 PTRHD1 ENSCCAP00000031241 ENSCCAP00000031241 NFKB1 NFKB1 ATG13 ATG13 PRKAG3 PRKAG3 CAT CAT TP53 TP53 SESN2 SESN2 ADCY5 ADCY5 KRAS KRAS HRAS HRAS CREB3L4 CREB3L4 ADIPOQ ADIPOQ SESN3 SESN3 FOXO3 FOXO3 ENSCCAP00000026158 ENSCCAP00000026158 NRAS NRAS RHEB RHEB ENSCCAP00000025671 ENSCCAP00000025671 IGF1R IGF1R ADCY8 ADCY8 PRKAG2 PRKAG2 SIRT1 SIRT1 CAMK4 CAMK4 INS INS EIF4E EIF4E PRKAA1 PRKAA1 CREB5 CREB5 PIK3CB PIK3CB RPS6KB2 RPS6KB2 MTOR MTOR ADCY2 ADCY2 TSC1 TSC1 PIK3CA PIK3CA AKT2 AKT2 PPARG PPARG CREB3L2 CREB3L2 SESN1 SESN1 ADCY9 ADCY9 ULK1 ULK1 SOD2 SOD2 CREB3 CREB3 PPARGC1A PPARGC1A CREB1 CREB1 ADIPOR2 ADIPOR2 PIK3R3 PIK3R3 ADCY6 ADCY6 APPL1 APPL1 BAX BAX ADCY4 ADCY4 AKT1S1 AKT1S1 EIF4E2 EIF4E2 RPS6KB1 RPS6KB1 ATG101 ATG101 CAMKK2 CAMKK2 PIK3R1 PIK3R1 PRKAB1 PRKAB1 PIK3CD PIK3CD EHMT1 EHMT1 RHEBL1 RHEBL1 ADCY3 ADCY3 PRKACB PRKACB RELA RELA IRS2 IRS2 ATG5 ATG5 RB1CC1 RB1CC1 ENSCCAP00000010305 ENSCCAP00000010305 AKT3 AKT3 ATF6B ATF6B EIF4E1B EIF4E1B CREB3L3 CREB3L3 STK11 STK11 PRKAG1 PRKAG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INSRTyrosine-protein kinase receptor. (1352 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
KLKlotho. (1015 aa)
ATF4Activating transcription factor 4. (351 aa)
TSC2TSC complex subunit 2. (1777 aa)
FOXO1Forkhead box O1. (654 aa)
CSDE1Uncharacterized protein. (844 aa)
LOC108309036Uncharacterized protein. (342 aa)
IGF1Insulin like growth factor 1. (199 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1305 aa)
PIK3R2Uncharacterized protein. (727 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1268 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (276 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (132 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
IRS4Insulin receptor substrate 4. (1253 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ENSCCAP00000031241Uncharacterized protein. (387 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (527 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (487 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa)
SESN2Sestrin 2. (480 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (394 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
SESN3Sestrin 3. (522 aa)
FOXO3Forkhead box O3. (672 aa)
ENSCCAP00000026158CSD_1 domain-containing protein. (440 aa)
NRASUncharacterized protein. (189 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
ENSCCAP00000025671Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (118 aa)
IGF1RTyrosine-protein kinase receptor. (1285 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1249 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
SIRT1Sirtuin 1. (446 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (248 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
MTORSerine/threonine-protein kinase mTOR. (2508 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (902 aa)
TSC1TSC complex subunit 1. (1149 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
SESN1Sestrin 1. (543 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
ULK1Unc-51 like autophagy activating kinase 1. (964 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
CREB3cAMP responsive element binding protein 3. (374 aa)
PPARGC1APPARG coactivator 1 alpha. (812 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ADIPOR2Adiponectin receptor 2. (387 aa)
PIK3R3Uncharacterized protein. (577 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
BAXBCL2 associated X, apoptosis regulator. (159 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
AKT1S1AKT1 substrate 1. (276 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ATG101Autophagy related 101. (218 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1056 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (1284 aa)
RHEBL1RHEB like 1. (164 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IRS2Insulin receptor substrate 2. (1361 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
ENSCCAP00000010305Uncharacterized protein. (181 aa)
AKT3AKT serine/threonine kinase 3. (472 aa)
ATF6BActivating transcription factor 6 beta. (701 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (238 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (415 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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