STRINGSTRING
RB1 RB1 RASSF1 RASSF1 MAP2K2 MAP2K2 CASP9 CASP9 PPP1R14B PPP1R14B E2F2 E2F2 PLCG2 PLCG2 PIK3R1 PIK3R1 PIK3CD PIK3CD ENSCCAP00000010305 ENSCCAP00000010305 AKT3 AKT3 RAF1 RAF1 EML4 EML4 PLCG1 PLCG1 PRKCA PRKCA BAX BAX GADD45B GADD45B SOS2 SOS2 EGFR EGFR PRKCG PRKCG PIK3R3 PIK3R3 LOC108282680 LOC108282680 ENSCCAP00000013967 ENSCCAP00000013967 STAT5A STAT5A CDKN1A CDKN1A MAPK1 MAPK1 SOS1 SOS1 STK4 STK4 STAT3 STAT3 AKT2 AKT2 E2F3 E2F3 PIK3CA PIK3CA CCND1 CCND1 PIK3CB PIK3CB LOC108304334 LOC108304334 POLK POLK LTK LTK RASSF5 RASSF5 NRAS NRAS ENSCCAP00000026158 ENSCCAP00000026158 FOXO3 FOXO3 DDB2 DDB2 BRAF BRAF MET MET HRAS HRAS E2F1 E2F1 GRB2 GRB2 KRAS KRAS RXRA RXRA CDK4 CDK4 TGFA TGFA JAK3 JAK3 TP53 TP53 ERBB2 ERBB2 CDK6 CDK6 ENSCCAP00000030012 ENSCCAP00000030012 ALK ALK ENSCCAP00000031241 ENSCCAP00000031241 ENSCCAP00000031460 ENSCCAP00000031460 CDKN2A CDKN2A FHIT FHIT AKT1 AKT1 HGF HGF ENSCCAP00000034806 ENSCCAP00000034806 RXRG RXRG GADD45G GADD45G STAT5B STAT5B ARAF ARAF PRKCB PRKCB PIK3R2 PIK3R2 MAPK3 MAPK3 CSDE1 CSDE1 EGF EGF PDPK1 PDPK1 GADD45A GADD45A ENSCCAP00000038982 ENSCCAP00000038982 LOC108313247 LOC108313247 RARB RARB BAK1 BAK1 ENSCCAP00000003376 ENSCCAP00000003376 RXRB RXRB BAD BAD LOC108300898 LOC108300898
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RB1RB transcriptional corepressor 1. (927 aa)
RASSF1Ras association domain family member 1. (340 aa)
MAP2K2Mitogen-activated protein kinase kinase 2. (303 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (401 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (147 aa)
E2F2E2F transcription factor 2. (435 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1056 aa)
ENSCCAP00000010305Uncharacterized protein. (181 aa)
AKT3AKT serine/threonine kinase 3. (472 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
EML4Uncharacterized protein. (992 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
BAXBCL2 associated X, apoptosis regulator. (159 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (175 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
PIK3R3Uncharacterized protein. (577 aa)
LOC108282680Protein kinase domain-containing protein. (245 aa)
ENSCCAP00000013967WD_REPEATS_REGION domain-containing protein. (774 aa)
STAT5ASignal transducer and activator of transcription. (796 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (158 aa)
MAPK1Mitogen-activated protein kinase. (366 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1329 aa)
STK4Serine/threonine kinase 4. (487 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
E2F3E2F transcription factor 3. (461 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC108304334Protein kinase domain-containing protein. (342 aa)
POLKDNA polymerase kappa. (863 aa)
LTKTyrosine-protein kinase receptor. (863 aa)
RASSF5Ras association domain family member 5. (418 aa)
NRASUncharacterized protein. (189 aa)
ENSCCAP00000026158CSD_1 domain-containing protein. (440 aa)
FOXO3Forkhead box O3. (672 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
E2F1E2F transcription factor 1. (438 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RXRARetinoid X receptor alpha. (455 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
TGFATransforming growth factor alpha. (165 aa)
JAK3Tyrosine-protein kinase. (1115 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
ENSCCAP00000030012Protein kinase domain-containing protein. (266 aa)
ALKTyrosine-protein kinase receptor. (1621 aa)
ENSCCAP00000031241Uncharacterized protein. (387 aa)
ENSCCAP00000031460Protein kinase domain-containing protein. (272 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
ENSCCAP00000034806Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (260 aa)
RXRGRetinoid X receptor gamma. (463 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
STAT5BSignal transducer and activator of transcription. (788 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
PIK3R2Uncharacterized protein. (727 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CSDE1Uncharacterized protein. (844 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (562 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
ENSCCAP00000038982Uncharacterized protein. (128 aa)
LOC108313247Protein kinase domain-containing protein. (276 aa)
RARBRetinoic acid receptor beta. (448 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ENSCCAP00000003376Protein kinase domain-containing protein. (184 aa)
RXRBRetinoid X receptor beta. (538 aa)
BADBCL2 associated agonist of cell death. (167 aa)
LOC108300898Protein kinase domain-containing protein. (271 aa)
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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