STRINGSTRING
CLDN1 CLDN1 CFTR CFTR SALL2 SALL2 KIAA1143 KIAA1143 LGALS3 LGALS3 ST3GAL3 ST3GAL3 GAPDH GAPDH ESS2 ESS2 PQBP1 PQBP1 ELAVL3 ELAVL3 BCL2 BCL2 HLA-E HLA-E LOC105584593 LOC105584593 KCNH7 KCNH7 KRCC1 KRCC1 FGFR1 FGFR1 MET MET EML3 EML3 STN1 STN1 BARX2 BARX2 LOC105584599 LOC105584599 RIPK2 RIPK2 UBE2E3 UBE2E3 ENSCATP00000039367 ENSCATP00000039367 S100A8 S100A8 EML4 EML4 ENTPD4 ENTPD4 ENSCATP00000038453 ENSCATP00000038453 CBLC CBLC ARID4A ARID4A CDH1 CDH1 TEX48 TEX48 EGF EGF LOC105584595 LOC105584595 ELANE ELANE ALK ALK ENSCATP00000036174 ENSCATP00000036174 COX6B2 COX6B2 MIER1 MIER1 VEGFC VEGFC PRSS2 PRSS2 NOS3 NOS3 CCND1 CCND1 MALT1 MALT1 RARRES2 RARRES2 NT5C3A NT5C3A PROCA1 PROCA1 SFTPC SFTPC EGFR EGFR BRI3 BRI3 CCDC171 CCDC171 ZNF316 ZNF316 TCF7L1 TCF7L1 PCSK9 PCSK9 TP53 TP53 TNFRSF10B TNFRSF10B ANKS4B ANKS4B PPM1N PPM1N NTN5 NTN5 ANXA5 ANXA5 PPP1R14B PPP1R14B HS3ST3A1 HS3ST3A1 ABI2 ABI2 ABCD2 ABCD2 MYO7A MYO7A OVGP1 OVGP1 VCAM1 VCAM1 MYC MYC LBHD1 LBHD1 TNKS TNKS ENSCATP00000028439 ENSCATP00000028439 THAP10 THAP10 CDH5 CDH5 PPP1R14D PPP1R14D GPRC5A GPRC5A MTMR1 MTMR1 R3HDM2 R3HDM2 ZNF808 ZNF808 NR1I2 NR1I2 OCLN OCLN TSHR TSHR ENSCATP00000026130 ENSCATP00000026130 ICAM1 ICAM1 EMCN EMCN FBXO32 FBXO32 PPFIBP2 PPFIBP2 UBE2Q1 UBE2Q1 TACC1 TACC1 HECTD2 HECTD2 FBXO28 FBXO28 TJP1 TJP1 TMPRSS2 TMPRSS2 SERPINA5 SERPINA5 PPHLN1 PPHLN1 NACC1 NACC1 NNMT NNMT CLDN7 CLDN7 AEN AEN CD19 CD19 CTNNB1 CTNNB1 PRSS1 PRSS1 CCK CCK CEP57 CEP57 LOC105601173 LOC105601173 CTSE CTSE FGFR3 FGFR3 PRKRIP1 PRKRIP1 PHTF2 PHTF2 ENSCATP00000019657 ENSCATP00000019657 LOC105572981 LOC105572981 ATP2C1 ATP2C1 SUV39H2 SUV39H2 AMBP AMBP PRIMA1 PRIMA1 KNG1 KNG1 DYNAP DYNAP TDRD9 TDRD9 PCSK5 PCSK5 TMC1 TMC1 ALG9 ALG9 ACSBG1 ACSBG1 FGF1 FGF1 TMCO1 TMCO1 CD47 CD47 C2CD6 C2CD6 TWNK TWNK ENSCATP00000015483 ENSCATP00000015483 BRCA2 BRCA2 CD22 CD22 ACTB ACTB MUC5B MUC5B JMJD8 JMJD8 PCNA PCNA AR AR MAK16 MAK16 CLVS1 CLVS1 ESR1 ESR1 TOP2A TOP2A KRAS KRAS ERBB3 ERBB3 CASP3 CASP3 PGR PGR TM4SF4 TM4SF4 EMP1 EMP1 SLC15A1 SLC15A1 MYO7B MYO7B PECAM1 PECAM1 MEST MEST KDR KDR SLCO6A1 SLCO6A1 ERBB2 ERBB2 SELE SELE MAP3K21 MAP3K21 KCNQ2 KCNQ2 HEMK1 HEMK1 ART1 ART1 AKT1 AKT1 CLDN5 CLDN5 TAS2R38 TAS2R38 CCDC122 CCDC122 TENT5B TENT5B ZFC3H1 ZFC3H1 ZNF850 ZNF850 ERAS ERAS ATOH1 ATOH1 ENSCATP00000003905 ENSCATP00000003905 ADAMTSL5 ADAMTSL5 CCL16 CCL16 ACE2 ACE2 PCSK7 PCSK7 PACC1 PACC1 ADGRL3 ADGRL3 WDR89 WDR89 TTC39C TTC39C TMEM158 TMEM158 SMCO2 SMCO2 NKX3-1 NKX3-1 CCDC83 CCDC83 NAA15 NAA15 FGF2 FGF2 TNF TNF CCDC198 CCDC198 ZNF580 ZNF580 TRIM55 TRIM55 TMED7 TMED7 STON1 STON1 ENSCATP00000000152 ENSCATP00000000152
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
SALL2Spalt like transcription factor 2. (1009 aa)
KIAA1143KIAA1143. (154 aa)
LGALS3Galectin. (248 aa)
ST3GAL3ST3 beta-galactoside alpha-2,3-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (444 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
ESS2Ess-2 splicing factor homolog. (476 aa)
PQBP1Polyglutamine binding protein 1. (265 aa)
ELAVL3ELAV-like protein; Belongs to the RRM elav family. (367 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (356 aa)
LOC105584593Peptidase S1 domain-containing protein. (246 aa)
KCNH7Potassium voltage-gated channel subfamily H member 7. (1194 aa)
KRCC1Lysine rich coiled-coil 1. (259 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
EML3EMAP like 3. (874 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
BARX2BARX homeobox 2. (279 aa)
LOC105584599Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (262 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
UBE2E3UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (207 aa)
ENSCATP00000039367Uncharacterized protein. (360 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
EML4EMAP like 4. (1051 aa)
ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (617 aa)
ENSCATP00000038453Uncharacterized protein; Belongs to the peptidase C14A family. (262 aa)
CBLCCbl proto-oncogene C. (571 aa)
ARID4AAT-rich interaction domain 4A. (1263 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
TEX48Testis expressed 48. (120 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
LOC105584595Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (261 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (263 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
ENSCATP00000036174Uncharacterized protein. (290 aa)
COX6B2Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (88 aa)
MIER1MIER1 transcriptional regulator. (565 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa)
PRSS2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (248 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
MALT1MALT1 paracaspase. (824 aa)
RARRES2Retinoic acid receptor responder 2. (163 aa)
NT5C3A5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (336 aa)
PROCA1Protein interacting with cyclin A1. (363 aa)
SFTPCSurfactant protein C. (191 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
BRI3Brain protein I3. (125 aa)
CCDC171Coiled-coil domain containing 171. (1304 aa)
ZNF316Zinc finger protein 316. (1009 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (692 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
TNFRSF10BTNF receptor superfamily member 10b. (445 aa)
ANKS4BAnkyrin repeat and sterile alpha motif domain containing 4B. (417 aa)
PPM1NProtein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (430 aa)
NTN5Netrin 5. (489 aa)
ANXA5Annexin. (312 aa)
PPP1R14BUncharacterized protein. (207 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
ABI2Abl interactor 2. (513 aa)
ABCD2ATP binding cassette subfamily D member 2. (740 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2215 aa)
OVGP1Oviductal glycoprotein 1; Belongs to the glycosyl hydrolase 18 family. (662 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
LBHD1LBH domain containing 1. (245 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
ENSCATP00000028439UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
THAP10THAP domain containing 10. (257 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
PPP1R14DProtein phosphatase 1 regulatory inhibitor subunit 14D. (200 aa)
GPRC5AG protein-coupled receptor class C group 5 member A. (356 aa)
MTMR1Myotubularin related protein 1. (649 aa)
R3HDM2R3H domain containing 2. (1034 aa)
ZNF808Zinc finger protein 808. (939 aa)
NR1I2Nuclear receptor subfamily 1 group I member 2. (473 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (505 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
ENSCATP00000026130Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (394 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
EMCNEndomucin. (211 aa)
FBXO32F-box protein 32. (355 aa)
PPFIBP2PPFIA binding protein 2. (915 aa)
UBE2Q1Ubiquitin conjugating enzyme E2 Q1. (422 aa)
TACC1Transforming acidic coiled-coil containing protein 1. (793 aa)
HECTD2HECT domain E3 ubiquitin protein ligase 2. (759 aa)
FBXO28F-box protein 28. (368 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1742 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (489 aa)
SERPINA5Serpin family A member 5; Belongs to the serpin family. (406 aa)
PPHLN1Periphilin 1. (458 aa)
NACC1Nucleus accumbens associated 1. (527 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
AENApoptosis enhancing nuclease. (325 aa)
CD19CD19 molecule. (531 aa)
CTNNB1Catenin beta 1. (781 aa)
PRSS1Peptidase S1 domain-containing protein. (234 aa)
CCKCholecystokinin. (115 aa)
CEP57Centrosomal protein 57. (504 aa)
LOC105601173AB hydrolase-1 domain-containing protein. (265 aa)
CTSECathepsin E; Belongs to the peptidase A1 family. (422 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
PRKRIP1PRKR interacting protein 1. (185 aa)
PHTF2Putative homeodomain transcription factor 2. (787 aa)
ENSCATP00000019657Uncharacterized protein; Belongs to the actin family. (368 aa)
LOC105572981Uncharacterized protein. (132 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (983 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
AMBPAlpha-1-microglobulin/bikunin precursor. (352 aa)
PRIMA1Proline rich membrane anchor 1. (153 aa)
KNG1Kininogen 1. (644 aa)
DYNAPDynactin associated protein. (210 aa)
TDRD9Tudor domain containing 9. (1382 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1860 aa)
TMC1Transmembrane channel-like protein. (761 aa)
ALG9Mannosyltransferase. (622 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (723 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
TMCO1Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling; Belongs to the TMCO1 family. (208 aa)
CD47CD47 molecule. (312 aa)
C2CD6C2 calcium dependent domain containing 6. (1821 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
ENSCATP00000015483Glyceraldehyde-3-phosphate dehydrogenase. (334 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
CD22CD22 molecule. (848 aa)
ACTBUncharacterized protein. (375 aa)
MUC5BMucin 5B, oligomeric mucus/gel-forming. (5052 aa)
JMJD8Jumonji domain containing 8. (322 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ARAndrogen receptor. (897 aa)
MAK16Protein MAK16 homolog; Belongs to the MAK16 family. (300 aa)
CLVS1Clavesin 1. (354 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1530 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1349 aa)
CASP3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
PGRProgesterone receptor. (933 aa)
TM4SF4Transmembrane 4 L six family member 4. (202 aa)
EMP1Epithelial membrane protein 1. (161 aa)
SLC15A1Solute carrier family 15 member 1. (709 aa)
MYO7BMyosin VIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2070 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (721 aa)
MESTMesoderm specific transcript. (335 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
SLCO6A1Solute carrier organic anion transporter family member. (717 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
SELESelectin E. (610 aa)
MAP3K21Mitogen-activated protein kinase kinase kinase. (1040 aa)
KCNQ2Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (872 aa)
HEMK1HemK methyltransferase family member 1. (338 aa)
ART1NAD(P)(+)--arginine ADP-ribosyltransferase. (327 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
TAS2R38Taste receptor type 2. (333 aa)
CCDC122Coiled-coil domain containing 122. (273 aa)
TENT5BTerminal nucleotidyltransferase 5B. (425 aa)
ZFC3H1Zinc finger C3H1-type containing. (1989 aa)
ZNF850Zinc finger protein 850. (1090 aa)
ERASES cell expressed Ras. (233 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
ENSCATP00000003905Uncharacterized protein. (92 aa)
ADAMTSL5ADAMTS like 5. (471 aa)
CCL16C-C motif chemokine. (112 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
PCSK7Proprotein convertase subtilisin/kexin type 7. (761 aa)
PACC1Proton activated chloride channel 1. (412 aa)
ADGRL3Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. (1580 aa)
WDR89WD repeat domain 89. (387 aa)
TTC39CTetratricopeptide repeat domain 39C. (582 aa)
TMEM158Transmembrane protein 158 (gene/pseudogene). (298 aa)
SMCO2Single-pass membrane protein with coiled-coil domains 2. (342 aa)
NKX3-1NK3 homeobox 1. (232 aa)
CCDC83Coiled-coil domain containing 83. (444 aa)
NAA15N(alpha)-acetyltransferase 15, NatA auxiliary subunit. (868 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CCDC198Coiled-coil domain containing 198. (336 aa)
ZNF580Zinc finger protein 580. (172 aa)
TRIM55Tripartite motif containing 55. (548 aa)
TMED7Transmembrane p24 trafficking protein 7. (224 aa)
STON1Stonin-1; May be involved in the endocytic machinery. (1182 aa)
ENSCATP00000000152Uncharacterized protein. (64 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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