STRINGSTRING
CBL CBL PDGFA PDGFA KIT KIT SH3GL2 SH3GL2 FGF2 FGF2 CSF1R CSF1R CBLB CBLB TIE1 TIE1 SH3GL3 SH3GL3 SOS1 SOS1 MST1R MST1R ENSCATP00000005869 ENSCATP00000005869 GAB1 GAB1 PDGFRA PDGFRA KITLG KITLG NRG4 NRG4 ENSCATP00000006855 ENSCATP00000006855 PGF PGF ENSCATP00000007407 ENSCATP00000007407 GRAP GRAP INSR INSR FGF3 FGF3 ERBB2 ERBB2 KLB KLB KDR KDR GRB10 GRB10 IGF1R IGF1R FGF9 FGF9 INSRR INSRR ERBB3 ERBB3 MST1 MST1 IRS1 IRS1 VEGFA VEGFA FGF16 FGF16 IL34 IL34 VEGFB VEGFB ANGPT1 ANGPT1 ENSCATP00000016044 ENSCATP00000016044 FGF8 FGF8 FGF1 FGF1 PDGFD PDGFD PTPN11 PTPN11 TEK TEK FGFR3 FGFR3 SPRY2 SPRY2 VEGFD VEGFD GAB2 GAB2 SH3KBP1 SH3KBP1 FLT1 FLT1 FGF4 FGF4 LRIG1 LRIG1 ANGPT2 ANGPT2 FGF11 FGF11 AREG AREG FLT4 FLT4 PDGFRL PDGFRL PDGFC PDGFC FGFRL1 FGFRL1 EPGN EPGN FGF6 FGF6 NRG3 NRG3 S100A13 S100A13 SHC1 SHC1 FRS2 FRS2 FGFR2 FGFR2 FGFR4 FGFR4 NRG1 NRG1 SH3GL1 SH3GL1 BTC BTC FGF19 FGF19 FGF10 FGF10 FGF23 FGF23 FRS3 FRS3 EGFR EGFR IDE IDE SHC4 SHC4 HGF HGF PTPN1 PTPN1 NTRK2 NTRK2 FGF18 FGF18 VEGFC VEGFC EREG EREG EGF EGF ANGPT4 ANGPT4 CBLC CBLC CSF1 CSF1 FGF22 FGF22 SOS2 SOS2 IGF2 IGF2 PDGFB PDGFB FGF7 FGF7 TGFA TGFA SPRY1 SPRY1 MET MET FGFR1 FGFR1 ERBB4 ERBB4 IGF1 IGF1 SHC3 SHC3 NTRK1 NTRK1 GRB2 GRB2 NRG2 NRG2 INS INS ENSCATP00000044421 ENSCATP00000044421 KL KL PDGFRB PDGFRB LRIG3 LRIG3 FGF17 FGF17 FGF5 FGF5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBLCbl proto-oncogene. (907 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
CBLBCbl proto-oncogene B. (1027 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (354 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MST1RMacrophage stimulating 1 receptor. (1426 aa)
ENSCATP00000005869Uncharacterized protein. (526 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1024 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
NRG4Neuregulin 4. (117 aa)
ENSCATP00000006855Uncharacterized protein. (519 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
ENSCATP00000007407PID domain-containing protein. (502 aa)
GRAPGRB2 related adaptor protein. (217 aa)
INSRTyrosine-protein kinase receptor. (1339 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
KLBKlotho beta. (1044 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
GRB10Growth factor receptor bound protein 10. (593 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
INSRRTyrosine-protein kinase receptor. (1296 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1349 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (409 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
IL34Interleukin 34. (242 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
ANGPT1Angiopoietin 1. (498 aa)
ENSCATP00000016044Protein kinase domain-containing protein. (357 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
GAB2GRB2 associated binding protein 2. (676 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (665 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1088 aa)
ANGPT2Angiopoietin 2. (495 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
AREGAmphiregulin. (274 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
PDGFRLPlatelet derived growth factor receptor like. (432 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
FGFRL1Fibroblast growth factor receptor like 1. (474 aa)
EPGNEpithelial mitogen. (154 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
NRG3Neuregulin 3. (720 aa)
S100A13S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa)
SHC1SHC adaptor protein 1. (584 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
NRG1Neuregulin 1. (713 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (396 aa)
BTCBetacellulin. (171 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
SHC4SHC adaptor protein 4. (630 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa)
EREGEpiregulin. (169 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
ANGPT4Angiopoietin 4. (503 aa)
CBLCCbl proto-oncogene C. (571 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
IGF2Insulin like growth factor 2. (236 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TGFATransforming growth factor alpha. (166 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
IGF1Insulin like growth factor 1. (208 aa)
SHC3SHC adaptor protein 3. (598 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
NRG2Neuregulin 2. (851 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ENSCATP00000044421Uncharacterized protein. (441 aa)
KLKlotho. (1001 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1119 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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