54 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	ENSCATP00000005869	Uncharacterized protein. (526 aa)
	GAB1	GRB2 associated binding protein 1. (724 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1024 aa)
	ENSCATP00000006855	Uncharacterized protein. (519 aa)
	ENSCATP00000007407	PID domain-containing protein. (502 aa)
	GRAP	GRB2 related adaptor protein. (217 aa)
	INSR	Tyrosine-protein kinase receptor. (1339 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
	KLB	Klotho beta. (1044 aa)
	GRB10	Growth factor receptor bound protein 10. (593 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1366 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	INSRR	Tyrosine-protein kinase receptor. (1296 aa)
	IRS1	Insulin receptor substrate 1. (1241 aa)
	ENSCATP00000016044	Protein kinase domain-containing protein. (357 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	PTPN11	Protein tyrosine phosphatase non-receptor type 11. (552 aa)
	FGFR3	Fibroblast growth factor receptor. (809 aa)
	GAB2	GRB2 associated binding protein 2. (676 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
	FGFRL1	Fibroblast growth factor receptor like 1. (474 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	SHC1	SHC adaptor protein 1. (584 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (522 aa)
	FGFR2	Fibroblast growth factor receptor. (840 aa)
	FGFR4	Fibroblast growth factor receptor. (802 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (492 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	NTRK2	Tyrosine-protein kinase receptor. (838 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
	IGF2	Insulin like growth factor 2. (236 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	FGFR1	Fibroblast growth factor receptor. (820 aa)
	IGF1	Insulin like growth factor 1. (208 aa)
	SHC3	SHC adaptor protein 3. (598 aa)
	NTRK1	Tyrosine-protein kinase receptor. (796 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	ENSCATP00000044421	Uncharacterized protein. (441 aa)
	KL	Klotho. (1001 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ENSCATP00000005869	ENSCATP00000033478	ENSCATP00000005869	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.931
EGFR	ENSCATP00000006855	ENSCATP00000033478	ENSCATP00000006855	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.995
EGFR	ENSCATP00000007407	ENSCATP00000033478	ENSCATP00000007407	Receptor protein-tyrosine kinase.	PID domain-containing protein.	0.970
EGFR	ENSCATP00000016044	ENSCATP00000033478	ENSCATP00000016044	Receptor protein-tyrosine kinase.	Protein kinase domain-containing protein.	0.411
EGFR	ENSCATP00000044421	ENSCATP00000033478	ENSCATP00000044421	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.931
EGFR	FGF1	ENSCATP00000033478	ENSCATP00000016793	Receptor protein-tyrosine kinase.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.819
EGFR	FGF10	ENSCATP00000033478	ENSCATP00000031660	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.840
EGFR	FGF17	ENSCATP00000033478	ENSCATP00000045929	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.877
EGFR	FGF18	ENSCATP00000033478	ENSCATP00000035596	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.839
EGFR	FGF19	ENSCATP00000033478	ENSCATP00000030962	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.810
EGFR	FGF2	ENSCATP00000033478	ENSCATP00000001121	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.870
EGFR	FGF22	ENSCATP00000033478	ENSCATP00000038554	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.840
EGFR	FGF23	ENSCATP00000033478	ENSCATP00000032032	Receptor protein-tyrosine kinase.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.779
EGFR	FGF3	ENSCATP00000033478	ENSCATP00000007994	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.841
EGFR	FGF4	ENSCATP00000033478	ENSCATP00000021933	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.839
EGFR	FGF5	ENSCATP00000033478	ENSCATP00000045960	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.839
EGFR	FGF6	ENSCATP00000033478	ENSCATP00000026367	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.841
EGFR	FGF7	ENSCATP00000033478	ENSCATP00000041058	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.840
EGFR	FGF8	ENSCATP00000033478	ENSCATP00000016325	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.839
EGFR	FGF9	ENSCATP00000033478	ENSCATP00000009949	Receptor protein-tyrosine kinase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.840