(40 nodes) Mixed, incl. Preribosome, large subunit precursor, and Ribosome biogenesis network (Cercocebus atys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GTPBP4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
	ENSCATP00000001351	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (200 aa)
	NOP2	NOP2 nucleolar protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (844 aa)
	RPF1	Ribosome production factor 1 homolog. (344 aa)
	NIFK	Nucleolar protein interacting with the FHA domain of MKI67. (293 aa)
	RRP1	Ribosomal RNA processing 1. (478 aa)
	RRS1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
	RRP1B	Ribosomal RNA processing 1B. (758 aa)
	ENSCATP00000005281	C2H2-type domain-containing protein. (134 aa)
	FTSJ3	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (846 aa)
	PUM3	Pumilio RNA binding family member 3. (683 aa)
	NSA2	NSA2 ribosome biogenesis factor. (260 aa)
	GNL2	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (731 aa)
	ENSCATP00000010945	Brix domain-containing protein. (257 aa)
	ENSCATP00000012673	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (217 aa)
	MAK16	Protein MAK16 homolog; Belongs to the MAK16 family. (300 aa)
	NIP7	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa)
	RSL1D1	Ribosomal L1 domain containing 1. (475 aa)
	GNL3L	G protein nucleolar 3 like. (582 aa)
	BOP1	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (746 aa)
	NOP53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (478 aa)
	DDX55	RNA helicase. (605 aa)
	RPF2	Brix domain-containing protein. (258 aa)
	NOC2L	NOC2 like nucleolar associated transcriptional repressor. (720 aa)
	WDR74	WD repeat domain 74. (385 aa)
	RSL24D1	Ribosomal L24 domain containing 1. (163 aa)
	WDR12	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (425 aa)
	NOC3L	Nucleolar complex protein 3 homolog. (799 aa)
	ENSCATP00000024305	WD_REPEATS_REGION domain-containing protein. (389 aa)
	ENSCATP00000026140	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (200 aa)
	LOC105572009	G domain-containing protein. (489 aa)
	DDX18	RNA helicase. (670 aa)
	PES1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (590 aa)
	ENSCATP00000028631	TRASH domain-containing protein. (71 aa)
	BRIX1	Biogenesis of ribosomes BRX1. (352 aa)
	EBNA1BP2	EBNA1 binding protein 2. (422 aa)
	NSUN6	NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (469 aa)
	NLE1	Notchless homolog 1. (487 aa)
	GNL3	G protein nucleolar 3. (549 aa)
	ENSCATP00000037306	Uncharacterized protein. (235 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOP1	BRIX1	ENSCATP00000017060	ENSCATP00000028898	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Biogenesis of ribosomes BRX1.	0.994
BOP1	DDX18	ENSCATP00000017060	ENSCATP00000026873	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	RNA helicase.	0.983
BOP1	DDX55	ENSCATP00000017060	ENSCATP00000021211	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	RNA helicase.	0.981
BOP1	EBNA1BP2	ENSCATP00000017060	ENSCATP00000028990	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	EBNA1 binding protein 2.	0.996
BOP1	ENSCATP00000001351	ENSCATP00000017060	ENSCATP00000001351	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.970
BOP1	ENSCATP00000005281	ENSCATP00000017060	ENSCATP00000005281	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	C2H2-type domain-containing protein.	0.762
BOP1	ENSCATP00000010945	ENSCATP00000017060	ENSCATP00000010945	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Brix domain-containing protein.	0.973
BOP1	ENSCATP00000012673	ENSCATP00000017060	ENSCATP00000012673	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.992
BOP1	ENSCATP00000024305	ENSCATP00000017060	ENSCATP00000024305	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	WD_REPEATS_REGION domain-containing protein.	0.993
BOP1	ENSCATP00000026140	ENSCATP00000017060	ENSCATP00000026140	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.	0.789
BOP1	ENSCATP00000028631	ENSCATP00000017060	ENSCATP00000028631	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	TRASH domain-containing protein.	0.976
BOP1	ENSCATP00000037306	ENSCATP00000017060	ENSCATP00000037306	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.956
BOP1	FTSJ3	ENSCATP00000017060	ENSCATP00000005827	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	0.990
BOP1	GNL2	ENSCATP00000017060	ENSCATP00000008744	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.986
BOP1	GNL3	ENSCATP00000017060	ENSCATP00000036122	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	G protein nucleolar 3.	0.986
BOP1	GNL3L	ENSCATP00000017060	ENSCATP00000015501	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	G protein nucleolar 3 like.	0.986
BOP1	GTPBP4	ENSCATP00000017060	ENSCATP00000000909	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.993
BOP1	LOC105572009	ENSCATP00000017060	ENSCATP00000026860	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	G domain-containing protein.	0.986
BOP1	MAK16	ENSCATP00000017060	ENSCATP00000012834	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.972
BOP1	NIFK	ENSCATP00000017060	ENSCATP00000004284	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Nucleolar protein interacting with the FHA domain of MKI67.	0.989