(5 nodes) NEDD8 activating enzyme activity, and Nedd8-like ubiquitin network (Cercocebus atys)

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Your Input:
	UBE2M	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	ENSCATP00000011066	Ubiquitin-like domain-containing protein. (74 aa)
	ENSCATP00000020111	UBIQUITIN_CONJUGAT_2 domain-containing protein. (148 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (499 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (463 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCATP00000011066	ENSCATP00000020111	ENSCATP00000011066	ENSCATP00000020111	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.858
ENSCATP00000011066	NAE1	ENSCATP00000011066	ENSCATP00000027139	Ubiquitin-like domain-containing protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.954
ENSCATP00000011066	UBA3	ENSCATP00000011066	ENSCATP00000042868	Ubiquitin-like domain-containing protein.	Ubiquitin like modifier activating enzyme 3.	0.964
ENSCATP00000011066	UBE2M	ENSCATP00000011066	ENSCATP00000010309	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.964
ENSCATP00000020111	ENSCATP00000011066	ENSCATP00000020111	ENSCATP00000011066	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.858
ENSCATP00000020111	NAE1	ENSCATP00000020111	ENSCATP00000027139	UBIQUITIN_CONJUGAT_2 domain-containing protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.881
ENSCATP00000020111	UBA3	ENSCATP00000020111	ENSCATP00000042868	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin like modifier activating enzyme 3.	0.906
ENSCATP00000020111	UBE2M	ENSCATP00000020111	ENSCATP00000010309	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.478
NAE1	ENSCATP00000011066	ENSCATP00000027139	ENSCATP00000011066	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ubiquitin-like domain-containing protein.	0.954
NAE1	ENSCATP00000020111	ENSCATP00000027139	ENSCATP00000020111	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.881
NAE1	UBA3	ENSCATP00000027139	ENSCATP00000042868	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ubiquitin like modifier activating enzyme 3.	0.999
NAE1	UBE2M	ENSCATP00000027139	ENSCATP00000010309	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.968
UBA3	ENSCATP00000011066	ENSCATP00000042868	ENSCATP00000011066	Ubiquitin like modifier activating enzyme 3.	Ubiquitin-like domain-containing protein.	0.964
UBA3	ENSCATP00000020111	ENSCATP00000042868	ENSCATP00000020111	Ubiquitin like modifier activating enzyme 3.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.906
UBA3	NAE1	ENSCATP00000042868	ENSCATP00000027139	Ubiquitin like modifier activating enzyme 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.999
UBA3	UBE2M	ENSCATP00000042868	ENSCATP00000010309	Ubiquitin like modifier activating enzyme 3.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.977
UBE2M	ENSCATP00000011066	ENSCATP00000010309	ENSCATP00000011066	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.964
UBE2M	ENSCATP00000020111	ENSCATP00000010309	ENSCATP00000020111	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.478
UBE2M	NAE1	ENSCATP00000010309	ENSCATP00000027139	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.968
UBE2M	UBA3	ENSCATP00000010309	ENSCATP00000042868	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin like modifier activating enzyme 3.	0.977