61 items (Cercocebus atys) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	BRD4	Bromodomain containing 4. (1217 aa)
	FOXF2	Forkhead box F2. (448 aa)
	UVSSA	UV stimulated scaffold protein A. (709 aa)
	LEO1	LEO1 homolog, Paf1/RNA polymerase II complex component. (672 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (323 aa)
	ELOF1	Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (120 aa)
	NOLC1	Nucleolar and coiled-body phosphoprotein 1. (703 aa)
	DHX9	DExH-box helicase 9. (1275 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	ENSCATP00000012244	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (417 aa)
	SCAF4	SR-related CTD associated factor 4. (1151 aa)
	RUVBL1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
	AR	Androgen receptor. (897 aa)
	ENSCATP00000013482	Uncharacterized protein. (204 aa)
	WAC	WW domain containing adaptor with coiled-coil. (631 aa)
	WDR43	WD repeat domain 43. (678 aa)
	ESRRB	Estrogen related receptor beta. (475 aa)
	AGO1	Argonaute RISC component 1; Belongs to the argonaute family. (858 aa)
	CCAR2	Cell cycle and apoptosis regulator 2. (923 aa)
	LLPH	LLP homolog, long-term synaptic facilitation factor. (123 aa)
	ENSCATP00000016845	Uncharacterized protein. (99 aa)
	CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (964 aa)
	PCIF1	PDX1 C-terminal inhibiting factor 1. (704 aa)
	CTR9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1157 aa)
	IWS1	Interacts with SUPT6H, CTD assembly factor 1. (819 aa)
	SCAF1	SR-related CTD associated factor 1. (1311 aa)
	RPRD2	Regulation of nuclear pre-mRNA domain containing 2. (1408 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
	GTF2F1	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (517 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (825 aa)
	SCAF8	SR-related CTD associated factor 8. (1337 aa)
	NCOA3	Nuclear receptor coactivator. (1428 aa)
	TAF7L	TATA-box binding protein associated factor 7 like. (464 aa)
	RUVBL2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (465 aa)
	DRAP1	DR1 associated protein 1. (205 aa)
	NOP58	NOP58 ribonucleoprotein. (530 aa)
	RPRD1B	Regulation of nuclear pre-mRNA domain containing 1B. (326 aa)
	TBP	TATA-box binding protein. (327 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (859 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
	ENSCATP00000032095	MYND-type domain-containing protein. (192 aa)
	TAF1	Transcription initiation factor TFIID subunit. (1927 aa)
	EDF1	HTH cro/C1-type domain-containing protein. (148 aa)
	FBF1	Fas binding factor 1. (1132 aa)
	GTF2A2	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
	PCF11	PCF11 cleavage and polyadenylation factor subunit. (1686 aa)
	CDC73	Cell division cycle 73. (531 aa)
	SMYD3	Uncharacterized protein. (288 aa)
	LOC105577056	HTH cro/C1-type domain-containing protein. (140 aa)
	URI1	URI1 prefoldin like chaperone. (543 aa)
	ZNHIT6	Zinc finger HIT-type containing 6. (470 aa)
	TCF4	Transcription factor 4. (773 aa)
	ENSCATP00000041238	TFIIA_gamma_N domain-containing protein. (91 aa)
	PAF1	PAF1 homolog, Paf1/RNA polymerase II complex component. (531 aa)
	SMYD2	SET and MYND domain containing 2. (426 aa)
	GTF2A1	General transcription factor IIA subunit 1. (376 aa)
	RTRAF	RNA transcription, translation and transport factor. (204 aa)
	GTF2B	General transcription factor IIB. (373 aa)
	ZNF326	Zinc finger protein 326; Belongs to the AKAP95 family. (579 aa)
	RPRD1A	Regulation of nuclear pre-mRNA domain containing 1A. (297 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSCATP00000015086	ENSCATP00000031524	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.972
AGO1	DHX9	ENSCATP00000015086	ENSCATP00000009379	Argonaute RISC component 1; Belongs to the argonaute family.	DExH-box helicase 9.	0.618
AGO2	AGO1	ENSCATP00000031524	ENSCATP00000015086	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC component 1; Belongs to the argonaute family.	0.972
AGO2	CTR9	ENSCATP00000031524	ENSCATP00000019106	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CTR9 homolog, Paf1/RNA polymerase II complex component.	0.587
AGO2	DHX9	ENSCATP00000031524	ENSCATP00000009379	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DExH-box helicase 9.	0.877
AGO2	ENSCATP00000016845	ENSCATP00000031524	ENSCATP00000016845	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Uncharacterized protein.	0.587
AR	BRD4	ENSCATP00000013225	ENSCATP00000000850	Androgen receptor.	Bromodomain containing 4.	0.580
AR	ESR1	ENSCATP00000013225	ENSCATP00000012127	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.591
AR	NCOA3	ENSCATP00000013225	ENSCATP00000025120	Androgen receptor.	Nuclear receptor coactivator.	0.948
AR	TP53	ENSCATP00000013225	ENSCATP00000032045	Androgen receptor.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.521
BRD4	AR	ENSCATP00000000850	ENSCATP00000013225	Bromodomain containing 4.	Androgen receptor.	0.580
BRD4	RUVBL1	ENSCATP00000000850	ENSCATP00000012777	Bromodomain containing 4.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.429
BRD4	RUVBL2	ENSCATP00000000850	ENSCATP00000028084	Bromodomain containing 4.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.423
BRD4	SMYD2	ENSCATP00000000850	ENSCATP00000041836	Bromodomain containing 4.	SET and MYND domain containing 2.	0.512
BRD4	TAF1	ENSCATP00000000850	ENSCATP00000033482	Bromodomain containing 4.	Transcription initiation factor TFIID subunit.	0.537
BRD4	TAF7L	ENSCATP00000000850	ENSCATP00000027637	Bromodomain containing 4.	TATA-box binding protein associated factor 7 like.	0.746
BRD4	TBP	ENSCATP00000000850	ENSCATP00000031165	Bromodomain containing 4.	TATA-box binding protein.	0.424
BRD4	TP53	ENSCATP00000000850	ENSCATP00000032045	Bromodomain containing 4.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.809
CCAR2	ZNF326	ENSCATP00000015797	ENSCATP00000045646	Cell cycle and apoptosis regulator 2.	Zinc finger protein 326; Belongs to the AKAP95 family.	0.581
CDC73	CTR9	ENSCATP00000036580	ENSCATP00000019106	Cell division cycle 73.	CTR9 homolog, Paf1/RNA polymerase II complex component.	0.988