50 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa)
	CBL	Cbl proto-oncogene. (907 aa)
	SOCS3	Suppressor of cytokine signaling 3. (225 aa)
	CBLB	Cbl proto-oncogene B. (1027 aa)
	SYK	Non-specific protein-tyrosine kinase. (637 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
	PTPN5	Protein tyrosine phosphatase non-receptor type 5. (566 aa)
	RASA1	RAS p21 protein activator 1. (1051 aa)
	ENSCATP00000005869	Uncharacterized protein. (526 aa)
	ENSCATP00000007407	PID domain-containing protein. (502 aa)
	GRAP	GRB2 related adaptor protein. (217 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (308 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
	IRS1	Insulin receptor substrate 1. (1241 aa)
	ENSCATP00000012914	Tyrosine-protein kinase. (399 aa)
	GRAP2	GRB2 related adaptor protein 2. (330 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	SHE	Src homology 2 domain containing E. (495 aa)
	SH3BP2	SH3 domain binding protein 2. (605 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (856 aa)
	STAP1	Signal transducing adaptor family member 1. (295 aa)
	PTPN11	Protein tyrosine phosphatase non-receptor type 11. (552 aa)
	HCK	Tyrosine-protein kinase. (504 aa)
	ABL2	Tyrosine-protein kinase. (1172 aa)
	PIK3R2	Uncharacterized protein. (624 aa)
	SHF	Src homology 2 domain containing F. (424 aa)
	BCAR3	BCAR3 adaptor protein, NSP family member. (825 aa)
	LOC105585293	Uncharacterized protein. (290 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (868 aa)
	SHD	Src homology 2 domain containing transforming protein D. (340 aa)
	YES1	Tyrosine-protein kinase. (543 aa)
	SHC1	SHC adaptor protein 1. (584 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	SHB	SH2 domain containing adaptor protein B. (509 aa)
	ZAP70	Tyrosine-protein kinase. (619 aa)
	NCK2	Cytoplasmic protein. (382 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	SH2D3A	SH2 domain containing 3A. (576 aa)
	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1. (441 aa)
	SH2D3C	SH2 domain containing 3C. (860 aa)
	CBLC	Cbl proto-oncogene C. (571 aa)
	CRK	CRK proto-oncogene, adaptor protein. (304 aa)
	PTPN3	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (913 aa)
	SHC3	SHC adaptor protein 3. (598 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	LCK	Tyrosine-protein kinase. (540 aa)
	FGR	Tyrosine-protein kinase. (496 aa)
	ENSCATP00000044421	Uncharacterized protein. (441 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSCATP00000017539	ENSCATP00000022840	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.927
ABL1	CBL	ENSCATP00000017539	ENSCATP00000000146	Tyrosine-protein kinase.	Cbl proto-oncogene.	0.983
ABL1	CBLB	ENSCATP00000017539	ENSCATP00000001807	Tyrosine-protein kinase.	Cbl proto-oncogene B.	0.723
ABL1	CBLC	ENSCATP00000017539	ENSCATP00000038009	Tyrosine-protein kinase.	Cbl proto-oncogene C.	0.601
ABL1	CRK	ENSCATP00000017539	ENSCATP00000038333	Tyrosine-protein kinase.	CRK proto-oncogene, adaptor protein.	0.991
ABL1	CRKL	ENSCATP00000017539	ENSCATP00000033735	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.999
ABL1	ENSCATP00000007407	ENSCATP00000017539	ENSCATP00000007407	Tyrosine-protein kinase.	PID domain-containing protein.	0.846
ABL1	GRAP	ENSCATP00000017539	ENSCATP00000007503	Tyrosine-protein kinase.	GRB2 related adaptor protein.	0.537
ABL1	GRAP2	ENSCATP00000017539	ENSCATP00000013424	Tyrosine-protein kinase.	GRB2 related adaptor protein 2.	0.537
ABL1	GRB2	ENSCATP00000017539	ENSCATP00000042750	Tyrosine-protein kinase.	Growth factor receptor bound protein 2.	0.986
ABL1	LOC105585293	ENSCATP00000017539	ENSCATP00000024270	Tyrosine-protein kinase.	Uncharacterized protein.	0.846
ABL1	MAPK1	ENSCATP00000017539	ENSCATP00000015951	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.556
ABL1	MAPK3	ENSCATP00000017539	ENSCATP00000011502	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.478
ABL1	PIK3R1	ENSCATP00000017539	ENSCATP00000027907	Tyrosine-protein kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.669
ABL1	SH3BP2	ENSCATP00000017539	ENSCATP00000017937	Tyrosine-protein kinase.	SH3 domain binding protein 2.	0.448
ABL1	SHC1	ENSCATP00000017539	ENSCATP00000027137	Tyrosine-protein kinase.	SHC adaptor protein 1.	0.846
ABL1	SHC3	ENSCATP00000017539	ENSCATP00000042032	Tyrosine-protein kinase.	SHC adaptor protein 3.	0.916
ABL2	ABL1	ENSCATP00000022840	ENSCATP00000017539	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.927
ABL2	CBL	ENSCATP00000022840	ENSCATP00000000146	Tyrosine-protein kinase.	Cbl proto-oncogene.	0.896
ABL2	CBLB	ENSCATP00000022840	ENSCATP00000001807	Tyrosine-protein kinase.	Cbl proto-oncogene B.	0.723