STRINGSTRING
PRKCA PRKCA XDH XDH ENSCATP00000036866 ENSCATP00000036866 CCL24 CCL24 NR4A1 NR4A1 LRG1 LRG1 NRAS NRAS SIRT1 SIRT1 VEGFC VEGFC PROK1 PROK1 NF1 NF1 BMP6 BMP6 NRP1 NRP1 SYNJ2BP SYNJ2BP ACVRL1 ACVRL1 SIRT6 SIRT6 PRL PRL STAT1 STAT1 STAT5A STAT5A FGF10 FGF10 PROX1 PROX1 PLXNB3 PLXNB3 DLL4 DLL4 GDF2 GDF2 KRIT1 KRIT1 ADAM17 ADAM17 SULF1 SULF1 APELA APELA CCR3 CCR3 ARG1 ARG1 IL10 IL10 EMC10 EMC10 JCAD JCAD IL12B IL12B F3 F3 FLT4 FLT4 COL4A3 COL4A3 PLCG1 PLCG1 CYBA CYBA AIMP1 AIMP1 FLT1 FLT1 VEGFD VEGFD TEK TEK AKT3 AKT3 BMPR2 BMPR2 ECM1 ECM1 PDPK1 PDPK1 VIP VIP STAT3 STAT3 THBS1 THBS1 MYDGF MYDGF NRP2 NRP2 WNT5A WNT5A THBS4 THBS4 ITGB3 ITGB3 SPARC SPARC ENSCATP00000016044 ENSCATP00000016044 CAV2 CAV2 PPP1R16B PPP1R16B VEGFB VEGFB NR2F2 NR2F2 EGF EGF LEP LEP EGR3 EGR3 CAV1 CAV1 NGFR NGFR CNMD CNMD PDCD10 PDCD10 VEGFA VEGFA TNMD TNMD APOH APOH ALOX5 ALOX5 PTPRM PTPRM GHRL GHRL TGFBR1 TGFBR1 ITGA4 ITGA4 APOE APOE KDR KDR ATP5F1A ATP5F1A TNFSF12 TNFSF12 HIF1A HIF1A PGF PGF RPTOR RPTOR AKT1 AKT1 VASH1 VASH1 APLNR APLNR SP1 SP1 GATA2 GATA2 FUT1 FUT1 DBH DBH ENSCATP00000003834 ENSCATP00000003834 NRARP NRARP PRKD2 PRKD2 TIE1 TIE1 HTR2B HTR2B PRKD1 PRKD1 CXCL12 CXCL12 ZNF580 ZNF580 MEF2C MEF2C AGGF1 AGGF1 IL12A IL12A ARNT ARNT PIK3CD PIK3CD MMRN2 MMRN2 MDK MDK BMP4 BMP4 TBC1D31 TBC1D31 SEMA5A SEMA5A SCG2 SCG2 ATOH8 ATOH8 IGF2 IGF2 VASH2 VASH2 PDGFB PDGFB AGTR1 AGTR1 FGF7 FGF7 FGFR1 FGFR1 ENG ENG GHSR GHSR ATP5IF1 ATP5IF1 HMOX1 HMOX1 BMP2 BMP2 RGCC RGCC CCL26 CCL26
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
XDHXanthine dehydrogenase. (1333 aa)
ENSCATP00000036866Uncharacterized protein. (55 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (670 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SIRT1Sirtuin 1. (744 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa)
PROK1Prokineticin 1. (105 aa)
NF1Neurofibromin 1. (2839 aa)
BMP6Bone morphogenetic protein 6. (520 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (926 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa)
SIRT6Sirtuin 6. (355 aa)
PRLProlactin. (227 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PROX1Prospero homeobox 1. (737 aa)
PLXNB3Plexin B3. (1904 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa)
GDF2Growth differentiation factor 2. (429 aa)
KRIT1Uncharacterized protein. (736 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
APELAUncharacterized protein. (54 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
ARG1Arginase. (322 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
EMC10ER membrane protein complex subunit 10. (345 aa)
JCADJunctional cadherin 5 associated. (1373 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (328 aa)
F3Coagulation factor III, tissue factor. (296 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (321 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (997 aa)
ECM1Extracellular matrix protein 1. (540 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (534 aa)
VIPVasoactive intestinal peptide. (170 aa)
STAT3Signal transducer and activator of transcription. (777 aa)
THBS1Thrombospondin 1. (1170 aa)
MYDGFMyeloid derived growth factor. (190 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (382 aa)
THBS4Thrombospondin 4. (935 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
ENSCATP00000016044Protein kinase domain-containing protein. (357 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (568 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
EGR3Early growth response 3. (387 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NGFRNerve growth factor receptor. (427 aa)
CNMDChondromodulin. (361 aa)
PDCD10Programmed cell death 10. (212 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (409 aa)
TNMDTenomodulin. (317 aa)
APOHApolipoprotein H. (323 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1465 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
APOEApolipoprotein E. (317 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (584 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (250 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (831 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1314 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VASH1Vasohibin 1. (365 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
SP1Sp1 transcription factor. (786 aa)
GATA2GATA binding protein 2. (480 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (366 aa)
DBHDopamine beta-hydroxylase. (620 aa)
ENSCATP00000003834PTN_MK_N domain-containing protein. (60 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (881 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
ZNF580Zinc finger protein 580. (172 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
AGGF1Uncharacterized protein. (710 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MMRN2Multimerin 2. (953 aa)
MDKMidkine. (143 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TBC1D31TBC1 domain family member 31. (1067 aa)
SEMA5ASemaphorin 5A. (1074 aa)
SCG2Secretogranin II. (703 aa)
ATOH8Atonal bHLH transcription factor 8. (363 aa)
IGF2Insulin like growth factor 2. (236 aa)
VASH2Vasohibin 2. (355 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
ENGEndoglin. (658 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
HMOX1Heme oxygenase 1. (311 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
RGCCRegulator of cell cycle. (137 aa)
CCL26C-C motif chemokine. (94 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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