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| | RAD54L | RAD54 like. (747 aa) |
| | POLR2H | RNA polymerase II subunit H. (169 aa) |
| | WDR48 | WD repeat domain 48. (679 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (994 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | TEN1 | Uncharacterized protein. (123 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | RBMS1 | RNA binding motif single stranded interacting protein 1. (406 aa) |
| | CRY2 | Cryptochrome circadian regulator 2. (593 aa) |
| | SSBP2 | LisH domain-containing protein. (369 aa) |
| | FUBP1 | Far upstream element binding protein 1. (655 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (1049 aa) |
| | ENSCATP00000036401 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1243 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (397 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (944 aa) |
| | LONP1 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (961 aa) |
| | BLM | BLM RecQ like helicase. (1416 aa) |
| | HMCES | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (355 aa) |
| | LOC105578309 | Ubiquitin-like domain-containing protein. (342 aa) |
| | POLR3C | RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa) |
| | POLA1 | DNA polymerase. (1469 aa) |
| | RAD18 | RAD18 E3 ubiquitin protein ligase. (505 aa) |
| | MYEF2 | Myelin expression factor 2. (600 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | SSBP3 | Single stranded DNA binding protein 3. (388 aa) |
| | TERF2 | Telomeric repeat binding factor 2. (542 aa) |
| | FAM111A | Family with sequence similarity 111 member A. (611 aa) |
| | PCBP3 | Poly(rC) binding protein 3. (371 aa) |
| | NOL12 | Uncharacterized protein. (213 aa) |
| | NABP1 | Nucleic acid binding protein 1. (204 aa) |
| | ENSCATP00000030060 | Uncharacterized protein. (281 aa) |
| | TERF2IP | TERF2 interacting protein. (400 aa) |
| | DHX36 | DEAH-box helicase 36. (1011 aa) |
| | POU4F1 | POU domain protein. (389 aa) |
| | SPRTN | SprT-like N-terminal domain. (488 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (319 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (603 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (939 aa) |
| | RAD23B | RAD23 homolog B, nucleotide excision repair protein. (409 aa) |
| | ENSCATP00000025828 | Uncharacterized protein. (278 aa) |
| | PCBP2 | Uncharacterized protein. (366 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa) |
| | HSF1 | Heat shock transcription factor 1. (532 aa) |
| | RAD51AP2 | RAD51 associated protein 2. (1159 aa) |
| | FBH1 | F-box DNA helicase 1. (998 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (148 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (825 aa) |
| | HROB | Chromosome 17 open reading frame 53. (640 aa) |
| | SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (250 aa) |
| | POLR2G | RNA polymerase II subunit G. (244 aa) |
| | BIVM | BIVM-ERCC5 readthrough. (1636 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | NEIL3 | Nei like DNA glycosylase 3. (602 aa) |
| | RAD51 | RAD51 recombinase; Belongs to the RecA family. (309 aa) |
| | ENSCATP00000019356 | RPA_C domain-containing protein. (276 aa) |
| | ENSCATP00000019150 | CSD_1 domain-containing protein. (291 aa) |
| | HNRNPA2B1 | Heterogeneous nuclear ribonucleoprotein A2/B1. (353 aa) |
| | NUP35 | Nucleoporin 35. (278 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (877 aa) |
| | RTF1 | RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa) |
| | CDC45 | Cell division cycle 45. (598 aa) |
| | TSN | Translin. (228 aa) |
| | WBP11 | WW domain binding protein 11. (641 aa) |
| | SMC2 | Structural maintenance of chromosomes protein. (1197 aa) |
| | RAD51B | RAD51 paralog B. (425 aa) |
| | RADX | RPA1 related single stranded DNA binding protein, X-linked. (855 aa) |
| | TWNK | Twinkle mtDNA helicase. (684 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3419 aa) |
| | ENSCATP00000015067 | Uncharacterized protein. (288 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | LOC105584991 | Uncharacterized protein. (308 aa) |
| | IGHMBP2 | Immunoglobulin mu DNA binding protein 2. (938 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | SMC5 | SMC_N domain-containing protein. (1201 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | SETMAR | SET domain and mariner transposase fusion gene. (684 aa) |
| | LOC105594295 | Uncharacterized protein. (226 aa) |
| | CTC1 | CST telomere replication complex component 1. (1217 aa) |
| | POT1 | Protection of telomeres 1. (634 aa) |
| | DDX11 | DEAD/H-box helicase 11. (918 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | ENSCATP00000009666 | Uncharacterized protein. (121 aa) |
| | REXO4 | REX4 homolog, 3'-5' exonuclease. (422 aa) |
| | DHX9 | DExH-box helicase 9. (1275 aa) |
| | SSBP4 | Single stranded DNA binding protein 4. (385 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1287 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (388 aa) |
| | PURB | Purine rich element binding protein B. (312 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (637 aa) |
| | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1070 aa) |
| | YBX1 | CSD_1 domain-containing protein. (324 aa) |
| | FUBP3 | Far upstream element binding protein 3. (570 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (323 aa) |
| | PCBP1 | Poly(rC) binding protein 1. (356 aa) |
| | LRPPRC | PPR_long domain-containing protein. (1461 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | SHOC1 | Shortage in chiasmata 1. (1444 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1092 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (905 aa) |
| | RAD23A | RAD23 homolog A, nucleotide excision repair protein. (363 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (352 aa) |
