STRINGSTRING
RAD23A RAD23A PNKP PNKP HUS1B HUS1B POLE POLE UVSSA UVSSA COMMD1 COMMD1 POLK POLK ERCC1 ERCC1 CETN1 CETN1 POLR2I POLR2I LIG4 LIG4 RPA3 RPA3 OGG1 OGG1 CETN2 CETN2 POLD1 POLD1 ENSCATP00000011714 ENSCATP00000011714 ERCC8 ERCC8 USP7 USP7 ERCC6 ERCC6 FANCC FANCC MNAT1 MNAT1 GTF2H3 GTF2H3 XAB2 XAB2 ENSCATP00000015198 ENSCATP00000015198 BRCA2 BRCA2 ERCC3 ERCC3 ENSCATP00000019280 ENSCATP00000019280 ENSCATP00000019356 ENSCATP00000019356 FAN1 FAN1 ERCC4 ERCC4 BIVM BIVM USP45 USP45 HUS1 HUS1 MMS19 MMS19 GTF2H1 GTF2H1 RAD23B RAD23B XPC XPC DDB2 DDB2 ATXN3 ATXN3 KAT5 KAT5 TP53 TP53 LOC105578309 LOC105578309 NTHL1 NTHL1 SIRT1 SIRT1 ENSCATP00000036401 ENSCATP00000036401 LOC105599287 LOC105599287 BRIP1 BRIP1 XPA XPA POLD3 POLD3 GTF2H4 GTF2H4 HMGN1 HMGN1 SLX4 SLX4 GTF2H5 GTF2H5 RPA2 RPA2 ENSCATP00000044320 ENSCATP00000044320
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAD23ARAD23 homolog A, nucleotide excision repair protein. (363 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (277 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
UVSSAUV stimulated scaffold protein A. (709 aa)
COMMD1Copper metabolism domain containing 1. (190 aa)
POLKDNA polymerase kappa. (845 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (323 aa)
CETN1Centrin 1. (172 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
LIG4DNA ligase. (911 aa)
RPA3Replication protein A3. (121 aa)
OGG18-oxoguanine DNA glycosylase. (401 aa)
CETN2Centrin 2. (163 aa)
POLD1DNA polymerase. (1107 aa)
ENSCATP00000011714Uncharacterized protein. (288 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
USP7Uncharacterized protein; Belongs to the peptidase C19 family. (1093 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1495 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
GTF2H3General transcription factor IIH subunit 3. (308 aa)
XAB2XPA binding protein 2. (734 aa)
ENSCATP00000015198Helicase ATP-binding domain-containing protein. (405 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
ENSCATP00000019280Uncharacterized protein. (111 aa)
ENSCATP00000019356RPA_C domain-containing protein. (276 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
BIVMBIVM-ERCC5 readthrough. (1636 aa)
USP45Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (815 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (939 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
ATXN3Ataxin 3. (366 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (537 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
LOC105578309Ubiquitin-like domain-containing protein. (342 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (297 aa)
SIRT1Sirtuin 1. (744 aa)
ENSCATP00000036401Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa)
LOC105599287Ssl1 domain-containing protein. (129 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
POLD3Uncharacterized protein. (466 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
HMGN1Uncharacterized protein. (116 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1813 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
RPA2Replication protein A2. (270 aa)
ENSCATP00000044320HELICc2 domain-containing protein. (288 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.