38 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TM7SF2	Transmembrane 7 superfamily member 2. (418 aa)
	CYB5R3	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (334 aa)
	APOA5	Apolipoprotein A5. (366 aa)
	MVK	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (418 aa)
	G6PD	Glucose-6-phosphate dehydrogenase. (543 aa)
	DHCR24	24-dehydrocholesterol reductase. (513 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
	PLPP6	Phospholipid phosphatase 6. (296 aa)
	CYP51A1	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (509 aa)
	FDFT1	Farnesyl-diphosphate farnesyltransferase 1. (417 aa)
	MSMO1	Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa)
	IDI2	Isopentenyl-diphosphate delta isomerase 2. (136 aa)
	HSD17B7	Hydroxysteroid 17-beta dehydrogenase 7. (359 aa)
	LBR	Lamin B receptor. (615 aa)
	DHCR7	7-dehydrocholesterol reductase. (500 aa)
	MVD	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (401 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	ENSCATP00000017225	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (364 aa)
	IDI1	Isopentenyl-diphosphate delta isomerase 1. (280 aa)
	ENSCATP00000021602	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (308 aa)
	NPC1L1	NPC1 like intracellular cholesterol transporter 1. (1356 aa)
	ACLY	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1155 aa)
	ARV1	ARV1 homolog, fatty acid homeostasis modulator. (271 aa)
	NSDHL	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (373 aa)
	EBP	EXPERA domain-containing protein. (230 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
	LSS	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (732 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	ENSCATP00000032038	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (403 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (574 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (238 aa)
	FDPS	Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (419 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1177 aa)
	SC5D	Sterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)
	ENSCATP00000040646	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (330 aa)
	PMVK	Phosphomevalonate kinase. (192 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	HMGCS1	ENSCATP00000024005	ENSCATP00000031649	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.895
ACLY	HMGCS2	ENSCATP00000024005	ENSCATP00000016879	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.890
ACLY	MVK	ENSCATP00000024005	ENSCATP00000002206	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.549
ACLY	PRKAA1	ENSCATP00000024005	ENSCATP00000033734	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Non-specific serine/threonine protein kinase.	0.485
ACLY	SREBF1	ENSCATP00000024005	ENSCATP00000037484	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Sterol regulatory element binding transcription factor 1.	0.409
CFTR	PRKAA1	ENSCATP00000045859	ENSCATP00000033734	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Non-specific serine/threonine protein kinase.	0.906
CFTR	PRKAA2	ENSCATP00000045859	ENSCATP00000036138	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	Non-specific serine/threonine protein kinase.	0.904
CYP51A1	DHCR24	ENSCATP00000007678	ENSCATP00000003212	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	24-dehydrocholesterol reductase.	0.999
CYP51A1	DHCR7	ENSCATP00000007678	ENSCATP00000015806	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	7-dehydrocholesterol reductase.	0.975
CYP51A1	EBP	ENSCATP00000007678	ENSCATP00000028743	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	EXPERA domain-containing protein.	0.571
CYP51A1	ENSCATP00000017225	ENSCATP00000007678	ENSCATP00000017225	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.620
CYP51A1	ENSCATP00000021602	ENSCATP00000007678	ENSCATP00000021602	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.620
CYP51A1	ENSCATP00000032038	ENSCATP00000007678	ENSCATP00000032038	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.620
CYP51A1	ENSCATP00000040646	ENSCATP00000007678	ENSCATP00000040646	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.620
CYP51A1	FDFT1	ENSCATP00000007678	ENSCATP00000008498	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Farnesyl-diphosphate farnesyltransferase 1.	0.990
CYP51A1	FDPS	ENSCATP00000007678	ENSCATP00000035894	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.	0.629
CYP51A1	HMGCR	ENSCATP00000007678	ENSCATP00000004012	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.917
CYP51A1	HMGCS1	ENSCATP00000007678	ENSCATP00000031649	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.920
CYP51A1	HMGCS2	ENSCATP00000007678	ENSCATP00000016879	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.905
CYP51A1	HSD17B7	ENSCATP00000007678	ENSCATP00000013706	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Hydroxysteroid 17-beta dehydrogenase 7.	0.990