STRINGSTRING
ATXN3 ATXN3 TP53INP1 TP53INP1 LOC105579290 LOC105579290 LOC105576629 LOC105576629 ENSCATP00000001052 ENSCATP00000001052 TRPV3 TRPV3 CXCL12 CXCL12 EIF2B4 EIF2B4 MAP2K7 MAP2K7 ENSCATP00000002884 ENSCATP00000002884 HSBP1L1 HSBP1L1 PMP22 PMP22 TCIM TCIM ENSCATP00000004545 ENSCATP00000004545 IER5L IER5L CETN1 CETN1 TRPV4 TRPV4 PIRT PIRT CRNN CRNN AKT1 AKT1 TRPV2 TRPV2 ENSCATP00000007548 ENSCATP00000007548 VCP VCP SLU7 SLU7 CALCA CALCA DNAJA4 DNAJA4 ENSCATP00000009428 ENSCATP00000009428 P2RX3 P2RX3 LOC105573467 LOC105573467 RPS6KB1 RPS6KB1 ASIC3 ASIC3 ANO1 ANO1 LYN LYN LRP11 LRP11 STUB1 STUB1 CD14 CD14 HSPA6 HSPA6 IGFBP7 IGFBP7 HSPB2 HSPB2 CASQ1 CASQ1 MKI67 MKI67 ARPP21 ARPP21 HIKESHI HIKESHI FGF1 FGF1 THBS1 THBS1 SCARA5 SCARA5 GCLC GCLC DNAJA1 DNAJA1 HSPB1 HSPB1 DNAJA2 DNAJA2 ENSCATP00000020007 ENSCATP00000020007 PTGS2 PTGS2 TRPM2 TRPM2 PKLR PKLR ENSCATP00000022567 ENSCATP00000022567 SLC52A3 SLC52A3 TACR1 TACR1 SUMO1 SUMO1 HSF1 HSF1 TFEC TFEC ENSCATP00000024775 ENSCATP00000024775 POLR2D POLR2D DAXX DAXX HSPB6 HSPB6 LOC105574632 LOC105574632 ENSCATP00000028019 ENSCATP00000028019 DNAJA3 DNAJA3 DHX36 DHX36 PSIP1 PSIP1 HSPA2 HSPA2 HTRA2 HTRA2 NOS1 NOS1 NF1 NF1 NOS3 NOS3 TPR TPR MTOR MTOR SOD1 SOD1 IL1A IL1A TRPV1 TRPV1 HSP90AA1 HSP90AA1 ST8SIA1 ST8SIA1 CPB2 CPB2 HDAC2 HDAC2 YWHAE YWHAE RBBP7 RBBP7 ENSCATP00000040576 ENSCATP00000040576 EIF2B5 EIF2B5 IGF1 IGF1 BAG3 BAG3 STAC STAC CRYAA CRYAA IRAK1 IRAK1 CLPB CLPB HMOX1 HMOX1 EIF2B2 EIF2B2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATXN3Ataxin 3. (366 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (241 aa)
LOC105579290Ig-like domain-containing protein. (350 aa)
LOC105576629Ig-like domain-containing protein. (377 aa)
ENSCATP00000001052J domain-containing protein. (325 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (790 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (543 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (517 aa)
ENSCATP00000002884HATPase_c domain-containing protein. (680 aa)
HSBP1L1Heat shock factor binding protein 1 like 1. (74 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
TCIMTranscriptional and immune response regulator. (106 aa)
ENSCATP00000004545Small ubiquitin-related modifier. (101 aa)
IER5LImmediate early response 5 like. (405 aa)
CETN1Centrin 1. (172 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
PIRTPhosphoinositide interacting regulator of transient receptor potential channels. (137 aa)
CRNNCornulin. (495 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (760 aa)
ENSCATP00000007548J domain-containing protein. (349 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
SLU7SLU7 homolog, splicing factor. (586 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
DNAJA4DnaJ heat shock protein family (Hsp40) member A4. (426 aa)
ENSCATP00000009428Rad60-SLD domain-containing protein. (91 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
LOC105573467Ig-like domain-containing protein; Belongs to the MHC class I family. (376 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (541 aa)
ANO1Anoctamin. (1057 aa)
LYNTyrosine-protein kinase. (507 aa)
LRP11LDL receptor related protein 11. (500 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (374 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (605 aa)
IGFBP7Insulin like growth factor binding protein 7. (282 aa)
HSPB2SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (182 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
MKI67Marker of proliferation Ki-67. (2989 aa)
ARPP21cAMP regulated phosphoprotein 21. (846 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
THBS1Thrombospondin 1. (1170 aa)
SCARA5Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...] (496 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
DNAJA1Uncharacterized protein. (397 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
DNAJA2DnaJ heat shock protein family (Hsp40) member A2. (412 aa)
ENSCATP00000020007Uncharacterized protein. (58 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1542 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
ENSCATP00000022567Rad60-SLD domain-containing protein. (78 aa)
SLC52A3Solute carrier family 52 member 3. (469 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
SUMO1Ubiquitin-like domain-containing protein. (146 aa)
HSF1Heat shock transcription factor 1. (532 aa)
TFECTranscription factor EC. (347 aa)
ENSCATP00000024775Uncharacterized protein. (90 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
DAXXDeath domain associated protein. (739 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (160 aa)
LOC105574632Uncharacterized protein. (372 aa)
ENSCATP00000028019HATPase_c domain-containing protein. (647 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
DHX36DEAH-box helicase 36. (1011 aa)
PSIP1PC4 and SFRS1 interacting protein 1. (530 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (602 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
NOS1Nitric oxide synthase 1. (1461 aa)
NF1Neurofibromin 1. (2839 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
TPRTranslocated promoter region, nuclear basket protein. (2439 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SOD1Superoxide dismutase 1. (154 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (271 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (847 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (831 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
CPB2Carboxypeptidase B2. (423 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (469 aa)
ENSCATP0000004057614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (196 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (721 aa)
IGF1Insulin like growth factor 1. (208 aa)
BAG3BCL2 associated athanogene 3. (575 aa)
STACSH3 and cysteine rich domain. (402 aa)
CRYAASHSP domain-containing protein; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (172 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (721 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (704 aa)
HMOX1Heme oxygenase 1. (311 aa)
EIF2B2Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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