STRINGSTRING
SEMA5A SEMA5A SRPX2 SRPX2 ZNF580 ZNF580 PLPP3 PLPP3 FGF2 FGF2 RRAS RRAS PRKD1 PRKD1 PRKD2 PRKD2 BSG BSG FUT1 FUT1 GATA2 GATA2 SP1 SP1 AKT1 AKT1 RHOB RHOB FOXC2 FOXC2 HIF1A HIF1A ENSCATP00000008398 ENSCATP00000008398 CD40 CD40 ATP5F1A ATP5F1A KDR KDR SCARB1 SCARB1 TGFB1 TGFB1 ALOX12 ALOX12 VEGFA VEGFA CCBE1 CCBE1 FGF16 FGF16 PLK2 PLK2 MAP3K3 MAP3K3 PRKCA PRKCA ANGPT1 ANGPT1 TSTA3 TSTA3 SPARC SPARC ITGB3 ITGB3 WNT5A WNT5A MAP2K3 MAP2K3 NRP2 NRP2 FGF1 FGF1 THBS1 THBS1 ABL1 ABL1 ANXA1 ANXA1 TDGF1 TDGF1 P2RX4 P2RX4 PDPK1 PDPK1 PTK2B PTK2B BMPR2 BMPR2 CALR CALR AKT3 AKT3 HSPB1 HSPB1 WNT7A WNT7A TEK TEK PTGS2 PTGS2 PLCG1 PLCG1 FLT4 FLT4 ETS1 ETS1 PIK3CB PIK3CB RHOJ RHOJ AMOT AMOT ITGB1BP1 ITGB1BP1 JCAD JCAD EMC10 EMC10 AGT AGT NFE2L2 NFE2L2 AAMP AAMP ATP5F1B ATP5F1B ADAM17 ADAM17 HDAC9 HDAC9 ZC3H12A ZC3H12A SMOC2 SMOC2 BCAR1 BCAR1 PROX1 PROX1 ENSCATP00000031545 ENSCATP00000031545 STAT5A STAT5A NUS1 NUS1 GRN GRN NRP1 NRP1 PIK3CG PIK3CG CIB1 CIB1 NOS3 NOS3 FGF18 FGF18 VEGFC VEGFC GPLD1 GPLD1 SIRT1 SIRT1 EGF EGF ANGPT4 ANGPT4 PIK3CD PIK3CD BMP4 BMP4 RIN2 RIN2 ATOH8 ATOH8 LGMN LGMN PDGFB PDGFB MET MET FGFR1 FGFR1 BCAS3 BCAS3 ROCK2 ROCK2 ANXA3 ANXA3 HDAC7 HDAC7 FOXP1 FOXP1 HMOX1 HMOX1 ADGRA2 ADGRA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA5ASemaphorin 5A. (1074 aa)
SRPX2Sushi repeat containing protein X-linked 2. (465 aa)
ZNF580Zinc finger protein 580. (172 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
RRASRAS related. (218 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (881 aa)
BSGBasigin (Ok blood group). (346 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (366 aa)
GATA2GATA binding protein 2. (480 aa)
SP1Sp1 transcription factor. (786 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RHOBRas homolog family member B. (196 aa)
FOXC2Forkhead box C2. (501 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (831 aa)
ENSCATP00000008398CFC domain-containing protein. (170 aa)
CD40CD40 molecule. (278 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (584 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (409 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ANGPT1Angiopoietin 1. (498 aa)
TSTA3Tissue specific transplantation antigen P35B. (321 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (382 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
THBS1Thrombospondin 1. (1170 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ANXA1Annexin. (352 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (182 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (534 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (997 aa)
CALRCalreticulin. (389 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
ETS1ETS proto-oncogene 1, transcription factor. (548 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
RHOJRas homolog family member J. (214 aa)
AMOTAngiomotin. (1098 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
JCADJunctional cadherin 5 associated. (1373 aa)
EMC10ER membrane protein complex subunit 10. (345 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
AAMPAngio associated migratory cell protein. (454 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (486 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
SMOC2SPARC related modular calcium binding 2. (449 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
PROX1Prospero homeobox 1. (737 aa)
ENSCATP00000031545Uncharacterized protein. (450 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
GRNGranulin precursor. (593 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (926 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
CIB1Calcium and integrin binding 1. (231 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (847 aa)
SIRT1Sirtuin 1. (744 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
ANGPT4Angiopoietin 4. (503 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
RIN2Ras and Rab interactor 2. (895 aa)
ATOH8Atonal bHLH transcription factor 8. (363 aa)
LGMNLegumain. (433 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
ANXA3Annexin. (323 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1017 aa)
FOXP1Forkhead box P1. (693 aa)
HMOX1Heme oxygenase 1. (311 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1339 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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