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THOC2 THOC2 NEU4 NEU4 TBX6 TBX6 LPAR1 LPAR1 SEMA3D SEMA3D LRRK2 LRRK2 ACP4 ACP4 SEMA5B SEMA5B TSC1 TSC1 ULK2 ULK2 DTNBP1 DTNBP1 DKK1 DKK1 KLK8 KLK8 RIT2 RIT2 BAG5 BAG5 ENSCATP00000021635 ENSCATP00000021635 SEMA3F SEMA3F CDK5 CDK5 CARM1 CARM1 LRP4 LRP4 FKBP4 FKBP4 BCL11A BCL11A SEMA3B SEMA3B SEMA3G SEMA3G RNF6 RNF6 RAB29 RAB29 SEMA4A SEMA4A SPP1 SPP1 EPHB2 EPHB2 SEMA4B SEMA4B TNR TNR UBE3A UBE3A KREMEN1 KREMEN1 CRMP1 CRMP1 GAK GAK ENSCATP00000028944 ENSCATP00000028944 SEMA6A SEMA6A MINAR1 MINAR1 GFI1 GFI1 SYNGAP1 SYNGAP1 ITM2C ITM2C MGARP MGARP EPHA4 EPHA4 SEMA4C SEMA4C PSEN1 PSEN1 DNM3 DNM3 DPYSL3 DPYSL3 SEMA3E SEMA3E CDKL3 CDKL3 RTN4RL1 RTN4RL1 NRP1 NRP1 MCF2 MCF2 IFRD1 IFRD1 PTPRG PTPRG CIB1 CIB1 SEMA4G SEMA4G EFNB3 EFNB3 RTN4 RTN4 SEMA4F SEMA4F DENND5A DENND5A FLNA FLNA PAQR3 PAQR3 MT3 MT3 KANK1 KANK1 SEMA6C SEMA6C SEMA5A SEMA5A ARHGAP4 ARHGAP4 PTPRO PTPRO ENSCATP00000040037 ENSCATP00000040037 HDAC2 HDAC2 NGEF NGEF ENSCATP00000040664 ENSCATP00000040664 MAP2 MAP2 MYLIP MYLIP PTPRS PTPRS PRKCSH PRKCSH DGUOK DGUOK ENSCATP00000042787 ENSCATP00000042787 KIAA0319 KIAA0319 SNAPIN SNAPIN SLIT2 SLIT2 FSTL4 FSTL4 SEMA6B SEMA6B FGF13 FGF13 SEMA4D SEMA4D MAG MAG WNT3A WNT3A EFNB2 EFNB2 ULK1 ULK1 DAB2 DAB2 NLGN1 NLGN1 SEMA3A SEMA3A STMN2 STMN2 SEMA7A SEMA7A APOE APOE LRIG2 LRIG2 DRAXIN DRAXIN ENSCATP00000010893 ENSCATP00000010893 RTN4RL2 RTN4RL2 EFNA1 EFNA1 RTN4R RTN4R PTPN9 PTPN9 B2M B2M ZNF365 ZNF365 PTEN PTEN PLXNA3 PLXNA3 NTN1 NTN1 RGMA RGMA WNT3 WNT3 CERS2 CERS2 SPOCK1 SPOCK1 STX1B STX1B RYK RYK SPART SPART INPP5J INPP5J SLIT1 SLIT1 NR2F1 NR2F1 GSK3A GSK3A ADCY6 ADCY6 THY1 THY1 GDI1 GDI1 TRIM46 TRIM46 WNT5A WNT5A DIP2B DIP2B ENSCATP00000008011 ENSCATP00000008011 DCC DCC RUFY3 RUFY3 VIM VIM TSKU TSKU GFAP GFAP EPHA7 EPHA7 TRPV4 TRPV4 INPP5F INPP5F PMP22 PMP22 IFRD2 IFRD2 ARF6 ARF6 ENSCATP00000001548 ENSCATP00000001548 CBFA2T2 CBFA2T2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THOC2THO complex 2. (1593 aa)
NEU4Neuraminidase 4. (484 aa)
TBX6T-box transcription factor 6. (436 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
ACP4Acid phosphatase 4; Belongs to the histidine acid phosphatase family. (426 aa)
SEMA5BSemaphorin 5B. (1125 aa)
TSC1TSC complex subunit 1. (1167 aa)
ULK2Unc-51 like autophagy activating kinase 2. (931 aa)
DTNBP1Dystrobrevin binding protein 1. (305 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (294 aa)
RIT2Ras like without CAAX 2. (217 aa)
BAG5BCL2 associated athanogene 5. (488 aa)
ENSCATP00000021635Uncharacterized protein. (194 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (661 aa)
LRP4LDL receptor related protein 4. (1913 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (835 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (749 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (782 aa)
RNF6Ring finger protein 6. (701 aa)
RAB29RAB29, member RAS oncogene family. (203 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (760 aa)
SPP1Secreted phosphoprotein 1. (324 aa)
EPHB2EPH receptor B2. (1085 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (836 aa)
TNRTenascin R. (1358 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (492 aa)
CRMP1Collapsin response mediator protein 1. (686 aa)
GAKCyclin G associated kinase. (1311 aa)
ENSCATP00000028944Uncharacterized protein. (892 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (916 aa)
GFI1Growth factor independent 1 transcriptional repressor. (422 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1303 aa)
ITM2CIntegral membrane protein 2C. (267 aa)
MGARPMitochondria localized glutamic acid rich protein. (225 aa)
EPHA4EPH receptor A4. (986 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
DPYSL3Dihydropyrimidinase like 3. (684 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (815 aa)
CDKL3Cyclin dependent kinase like 3. (592 aa)
RTN4RL1Reticulon 4 receptor like 1. (445 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (926 aa)
MCF2MCF.2 cell line derived transforming sequence. (1001 aa)
IFRD1Interferon related developmental regulator 1. (452 aa)
PTPRGProtein tyrosine phosphatase receptor type G. (1382 aa)
CIB1Calcium and integrin binding 1. (231 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
RTN4Reticulon. (1193 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
DENND5ADENN domain containing 5A. (1288 aa)
FLNAFilamin A. (2647 aa)
PAQR3Progestin and adipoQ receptor family member 3. (310 aa)
MT3Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
KANK1KN motif and ankyrin repeat domains 1. (1352 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (914 aa)
SEMA5ASemaphorin 5A. (1074 aa)
ARHGAP4Rho GTPase activating protein 4. (946 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
ENSCATP00000040037HECT domain-containing protein. (694 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
NGEFNeuronal guanine nucleotide exchange factor. (712 aa)
ENSCATP00000040664Uncharacterized protein. (558 aa)
MAP2Microtubule-associated protein. (1914 aa)
MYLIPMyosin regulatory light chain interacting protein. (445 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
PRKCSHProtein kinase C substrate 80K-H. (534 aa)
DGUOKDeoxyguanosine kinase. (277 aa)
ENSCATP00000042787Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (189 aa)
KIAA0319KIAA0319. (1069 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
FSTL4Follistatin like 4. (842 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (887 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
MAGMyelin associated glycoprotein. (772 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (333 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1038 aa)
DAB2DAB adaptor protein 2. (770 aa)
NLGN1Neuroligin 1. (823 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
STMN2Stathmin; Belongs to the stathmin family. (190 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (668 aa)
APOEApolipoprotein E. (317 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1038 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
ENSCATP00000010893Uncharacterized protein. (486 aa)
RTN4RL2Reticulon 4 receptor like 2. (259 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
RTN4RReticulon 4 receptor. (522 aa)
PTPN9Protein tyrosine phosphatase non-receptor type 9. (558 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
ZNF365Zinc finger protein 365. (411 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PLXNA3Plexin A3. (1871 aa)
NTN1Netrin 1. (575 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CERS2Ceramide synthase 2. (423 aa)
SPOCK1SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (439 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (288 aa)
RYKReceptor like tyrosine kinase. (613 aa)
SPARTSpartin. (666 aa)
INPP5JInositol polyphosphate-5-phosphatase J. (1001 aa)
SLIT1Slit guidance ligand 1. (1514 aa)
NR2F1Nuclear receptor subfamily 2 group F member 1. (423 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
THY1Thy-1 cell surface antigen. (161 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (465 aa)
TRIM46Tripartite motif containing 46. (759 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (382 aa)
DIP2BDisco interacting protein 2 homolog B. (1578 aa)
ENSCATP00000008011HECT domain-containing protein. (748 aa)
DCCDCC netrin 1 receptor. (1447 aa)
RUFY3RUN and FYVE domain containing 3. (579 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (517 aa)
EPHA7EPH receptor A7. (998 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1133 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
IFRD2Uncharacterized protein. (505 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ENSCATP00000001548Protein kinase domain-containing protein. (250 aa)
CBFA2T2CBFA2/RUNX1 partner transcriptional co-repressor 2. (602 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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