(42 nodes) Phosphatidylinositol 3-kinase signaling network (Cercocebus atys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRR5	Proline rich 5. (410 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	NYAP2	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2. (719 aa)
	IRS1	Insulin receptor substrate 1. (1241 aa)
	LTK	Tyrosine-protein kinase receptor. (864 aa)
	CD160	CD160 molecule. (234 aa)
	PIK3C2G	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1486 aa)
	BTN2A2	Uncharacterized protein. (519 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	IGF1	Insulin like growth factor 1. (208 aa)
	CD28	CD28 molecule. (234 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (880 aa)
	PEAR1	Platelet endothelial aggregation receptor 1. (1037 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	C1QBP	Complement C1q binding protein. (281 aa)
	NF1	Neurofibromin 1. (2839 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	MYO16	Myosin XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1855 aa)
	XBP1	BZIP domain-containing protein. (380 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (471 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
	PRR5L	Proline rich 5 like. (368 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
	PIK3R2	Uncharacterized protein. (624 aa)
	LOC105589237	Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor (By similarity). Binds IgG1 and IgG2. (336 aa)
	KBTBD2	Kelch repeat and BTB domain containing 2. (623 aa)
	ENSCATP00000014582	Uncharacterized protein. (161 aa)
	NYAP1	Neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1. (816 aa)
	EDN1	Endothelin 1. (211 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (481 aa)
	TPTE2	Uncharacterized protein. (550 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1399 aa)
	PREX2	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1606 aa)
	PLEKHA1	Pleckstrin homology domain containing A1. (362 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1366 aa)
	SERPINA12	Serpin family A member 12; Belongs to the serpin family. (414 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1349 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	CD28	ENSCATP00000006645	ENSCATP00000040854	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	CD28 molecule.	0.407
AKT1	ERBB3	ENSCATP00000006645	ENSCATP00000010580	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Erb-b2 receptor tyrosine kinase 3.	0.453
AKT1	IGF1	ENSCATP00000006645	ENSCATP00000041628	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin like growth factor 1.	0.553
AKT1	IRS1	ENSCATP00000006645	ENSCATP00000011875	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.579
AKT1	PIK3CA	ENSCATP00000006645	ENSCATP00000027089	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.971
AKT1	PIK3CB	ENSCATP00000006645	ENSCATP00000024233	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.950
AKT1	PIK3CD	ENSCATP00000006645	ENSCATP00000038140	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.936
AKT1	PIK3CG	ENSCATP00000006645	ENSCATP00000034511	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.951
AKT1	PIK3R1	ENSCATP00000006645	ENSCATP00000027907	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.951
AKT1	PIK3R2	ENSCATP00000006645	ENSCATP00000023918	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.925
AKT1	PIK3R5	ENSCATP00000006645	ENSCATP00000038945	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 5.	0.905
AKT1	PTEN	ENSCATP00000006645	ENSCATP00000013554	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.729
AKT1	TPTE2	ENSCATP00000006645	ENSCATP00000004010	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.571
AKT1	ZFP36L1	ENSCATP00000006645	ENSCATP00000041697	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	ZFP36 ring finger protein like 1.	0.473
CD28	AKT1	ENSCATP00000040854	ENSCATP00000006645	CD28 molecule.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.407
CD28	LOC105589237	ENSCATP00000040854	ENSCATP00000019810	CD28 molecule.	Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor (By similarity). Binds IgG1 and IgG2.	0.613
CD28	PIK3CA	ENSCATP00000040854	ENSCATP00000027089	CD28 molecule.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.899
CD28	PIK3CB	ENSCATP00000040854	ENSCATP00000024233	CD28 molecule.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.896
CD28	PIK3CD	ENSCATP00000040854	ENSCATP00000038140	CD28 molecule.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.905
CD28	PIK3R1	ENSCATP00000040854	ENSCATP00000027907	CD28 molecule.	Phosphoinositide-3-kinase regulatory subunit 1.	0.981