STRINGSTRING
SUPT5H SUPT5H ATP6V0B ATP6V0B MTMR8 MTMR8 WDR45 WDR45 ENSCATP00000001548 ENSCATP00000001548 CALCOCO2 CALCOCO2 MAPK8 MAPK8 SNX18 SNX18 RAB3GAP2 RAB3GAP2 QSOX1 QSOX1 ATP6V1E2 ATP6V1E2 RNF31 RNF31 NPC1 NPC1 RNF41 RNF41 MOAP1 MOAP1 SESN2 SESN2 CDK5R1 CDK5R1 LRRK2 LRRK2 AKT1 AKT1 EPM2A EPM2A C9orf72 C9orf72 HIF1A HIF1A EXOC8 EXOC8 ADRB2 ADRB2 UBQLN4 UBQLN4 ULK1 ULK1 KDR KDR PINK1 PINK1 LACRT LACRT PIP4K2B PIP4K2B TMEM39A TMEM39A TBC1D25 TBC1D25 RUFY4 RUFY4 SPTLC1 SPTLC1 ENSCATP00000012503 ENSCATP00000012503 KIAA1324 KIAA1324 LARP1 LARP1 IKBKG IKBKG WAC WAC ENSCATP00000014557 ENSCATP00000014557 ENSCATP00000014897 ENSCATP00000014897 VDAC1 VDAC1 ATP6V1G1 ATP6V1G1 ATP6V0A1 ATP6V0A1 ATG14 ATG14 ENSCATP00000016177 ENSCATP00000016177 FYCO1 FYCO1 VPS13D VPS13D EXOC4 EXOC4 DCN DCN TSC1 TSC1 WIPI1 WIPI1 NOD2 NOD2 ATG5 ATG5 ATG2A ATG2A TIGAR TIGAR ATP6V1C2 ATP6V1C2 PHF23 PHF23 TMEM39B TMEM39B VPS35 VPS35 ENSCATP00000020884 ENSCATP00000020884 CDK5 CDK5 PIP4K2A PIP4K2A RAB3GAP1 RAB3GAP1 POLDIP2 POLDIP2 SNX7 SNX7 CLEC16A CLEC16A ENSCATP00000024323 ENSCATP00000024323 NUPR1 NUPR1 SMCR8 SMCR8 ATP6V1H ATP6V1H SCFD1 SCFD1 BNIP3L BNIP3L SLC25A4 SLC25A4 FEZ2 FEZ2 HSPB8 HSPB8 RHEB RHEB PIK3CA PIK3CA EXOC7 EXOC7 ENSCATP00000027836 ENSCATP00000027836 AMBRA1 AMBRA1 ATP13A2 ATP13A2 PAFAH1B2 PAFAH1B2 ATP6V0A2 ATP6V0A2 PIP4K2C PIP4K2C ATP6V0C ATP6V0C SNX30 SNX30 TSC2 TSC2 VPS26A VPS26A ENSCATP00000029662 ENSCATP00000029662 PIK3R4 PIK3R4 TRIM13 TRIM13 SNX32 SNX32 NOD1 NOD1 SMG1 SMG1 TP53 TP53 SEC22B SEC22B RUBCN RUBCN UVRAG UVRAG SNX4 SNX4 SESN3 SESN3 CAPNS1 CAPNS1 GPSM1 GPSM1 HTT HTT MTOR MTOR ERN1 ERN1 SIRT1 SIRT1 PRKAA2 PRKAA2 IRGM IRGM TBK1 TBK1 VPS13C VPS13C USP30 USP30 PIK3C3 PIK3C3 NEDD4 NEDD4 LRSAM1 LRSAM1 SNX5 SNX5 FEZ1 FEZ1 RIPK2 RIPK2 IL4 IL4 UBQLN2 UBQLN2 HDAC6 HDAC6 ENSCATP00000041601 ENSCATP00000041601 EXOC1 EXOC1 CLN3 CLN3 BAG3 BAG3 USP36 USP36 MAPK10 MAPK10 TECPR1 TECPR1 STING1 STING1 LZTS1 LZTS1 CHMP4B CHMP4B EHMT2 EHMT2 GAPDH GAPDH SPTLC2 SPTLC2 HMOX1 HMOX1 WDR24 WDR24 NRBP2 NRBP2 BNIP3 BNIP3 SCOC SCOC ATP6V1B2 ATP6V1B2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUPT5HTranscription elongation factor SPT5. (1087 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (259 aa)
MTMR8Myotubularin related protein 8. (710 aa)
WDR45Uncharacterized protein. (360 aa)
ENSCATP00000001548Protein kinase domain-containing protein. (250 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (470 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
SNX18Sorting nexin. (624 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1412 aa)
QSOX1Sulfhydryl oxidase. (747 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
RNF31Uncharacterized protein. (1072 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
RNF41Ring finger protein 41. (317 aa)
MOAP1Modulator of apoptosis 1. (351 aa)
SESN2Sestrin 2. (480 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EPM2AEPM2A glucan phosphatase, laforin. (331 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (831 aa)
EXOC8Exocyst complex component 8. (725 aa)
ADRB2Adrenoceptor beta 2. (415 aa)
UBQLN4Ubiquilin 4. (601 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1038 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PINK1PTEN induced kinase 1. (581 aa)
LACRTLacritin. (137 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
TMEM39ATransmembrane protein 39A. (488 aa)
TBC1D25TBC1 domain family member 25. (688 aa)
RUFY4RUN and FYVE domain containing 4. (602 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (500 aa)
ENSCATP00000012503Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (280 aa)
KIAA1324KIAA1324. (865 aa)
LARP1La ribonucleoprotein domain family member 1. (1065 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
WACWW domain containing adaptor with coiled-coil. (631 aa)
ENSCATP00000014557Uncharacterized protein. (288 aa)
ENSCATP00000014897Uncharacterized protein. (280 aa)
VDAC1Uncharacterized protein. (279 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (803 aa)
ATG14Autophagy related 14. (510 aa)
ENSCATP00000016177Uncharacterized protein. (501 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1498 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4367 aa)
EXOC4Exocyst complex component 4. (974 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
TSC1TSC complex subunit 1. (1167 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ATG2AAutophagy related 2A. (1932 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
PHF23PHD finger protein 23. (403 aa)
TMEM39BTransmembrane protein 39B. (492 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
ENSCATP00000020884PX domain-containing protein. (337 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (989 aa)
POLDIP2DNA polymerase delta interacting protein 2. (408 aa)
SNX7Sorting nexin 7. (451 aa)
CLEC16AC-type lectin domain containing 16A. (1053 aa)
ENSCATP00000024323Uncharacterized protein. (271 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (472 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (641 aa)
BNIP3LBCL2 interacting protein 3 like. (179 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
FEZ2Fasciculation and elongation protein zeta 2. (382 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (196 aa)
RHEBRas homolog, mTORC1 binding. (196 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
ENSCATP00000027836SGNH_hydro domain-containing protein. (208 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1197 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (340 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
SNX30Sorting nexin family member 30. (437 aa)
TSC2TSC complex subunit 2. (1807 aa)
VPS26AVPS26, retromer complex component A. (327 aa)
ENSCATP00000029662Uncharacterized protein. (305 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
TRIM13Tripartite motif containing 13. (409 aa)
SNX32Sorting nexin; Involved in several stages of intracellular trafficking. (391 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3660 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
RUBCNRubicon autophagy regulator. (986 aa)
UVRAGUV radiation resistance associated. (699 aa)
SNX4Sorting nexin 4. (450 aa)
SESN3Sestrin 3. (530 aa)
CAPNS1Calpain small subunit 1. (293 aa)
GPSM1G protein signaling modulator 1. (704 aa)
HTTHuntingtin. (3113 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
SIRT1Sirtuin 1. (744 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
IRGMImmunity related GTPase M. (159 aa)
TBK1TANK binding kinase 1. (729 aa)
VPS13CVacuolar protein sorting 13 homolog C. (3754 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (517 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (708 aa)
SNX5Sorting nexin; Involved in several stages of intracellular trafficking. (405 aa)
FEZ1Fasciculation and elongation protein zeta 1. (392 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
UBQLN2Ubiquilin 2. (624 aa)
HDAC6Histone deacetylase 6. (1217 aa)
ENSCATP00000041601V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
EXOC1Exocyst complex component 1. (912 aa)
CLN3Battenin. (439 aa)
BAG3BCL2 associated athanogene 3. (575 aa)
USP36Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1124 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
TECPR1Tectonin beta-propeller repeat containing 1. (1165 aa)
STING1Transmembrane protein 173. (379 aa)
LZTS1Leucine zipper tumor suppressor 1. (596 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1266 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (565 aa)
HMOX1Heme oxygenase 1. (311 aa)
WDR24WD repeat domain 24. (908 aa)
NRBP2Nuclear receptor binding protein 2. (499 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
SCOCShort coiled-coil protein. (157 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (540 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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