STRINGSTRING
LOXL3 LOXL3 GTPBP4 GTPBP4 ENSCATP00000001543 ENSCATP00000001543 GLMN GLMN CXCL12 CXCL12 TNFSF18 TNFSF18 CCL28 CCL28 CBLB CBLB SOCS1 SOCS1 TBX21 TBX21 PTPN6 PTPN6 FOXP3 FOXP3 IHH IHH ASS1 ASS1 ARG2 ARG2 NRARP NRARP ENSCATP00000003834 ENSCATP00000003834 ITCH ITCH EPCAM EPCAM TMEM131L TMEM131L RUNX3 RUNX3 PTK2 PTK2 DLG1 DLG1 TRPV4 TRPV4 PDCD1LG2 PDCD1LG2 RAG2 RAG2 SOCS5 SOCS5 ENSCATP00000006016 ENSCATP00000006016 KLF4 KLF4 IFNB1 IFNB1 AKT1 AKT1 CEBPB CEBPB TARM1 TARM1 AKNA AKNA PAG1 PAG1 ENSCATP00000007363 ENSCATP00000007363 SOCS6 SOCS6 JAK3 JAK3 LRRC1 LRRC1 ICOSLG ICOSLG UBASH3B UBASH3B NOTCH1 NOTCH1 ERBB2 ERBB2 TGFB1 TGFB1 SPN SPN ADORA2A ADORA2A PTPN2 PTPN2 ALOX12 ALOX12 NEXMIF NEXMIF ZBTB7B ZBTB7B WNT1 WNT1 MBP MBP DUSP22 DUSP22 PODXL PODXL HLX HLX TNFRSF14 TNFRSF14 PTEN PTEN PDE5A PDE5A ADAMTS18 ADAMTS18 IFNL1 IFNL1 ZC3H8 ZC3H8 PELI1 PELI1 ILDR2 ILDR2 MYADM MYADM IL20RB IL20RB DLG5 DLG5 ABL1 ABL1 ANXA1 ANXA1 FGL2 FGL2 CD80 CD80 LOC105591569 LOC105591569 ABAT ABAT TSPAN32 TSPAN32 NDFIP1 NDFIP1 PLA2G2F PLA2G2F SCRIB SCRIB C1QTNF6 C1QTNF6 IDO1 IDO1 ENSCATP00000019334 ENSCATP00000019334 RC3H1 RC3H1 CD86 CD86 ENSCATP00000019834 ENSCATP00000019834 PPM1F PPM1F PLA2G2D PLA2G2D MAPK7 MAPK7 ZNF703 ZNF703 IL2 IL2 METTL3 METTL3 PAWR PAWR PRKCD PRKCD LEF1 LEF1 LAX1 LAX1 TWSG1 TWSG1 LOC105592931 LOC105592931 ENSCATP00000023477 ENSCATP00000023477 HAVCR2 HAVCR2 MAD2L2 MAD2L2 VTCN1 VTCN1 GPNMB GPNMB CRTAM CRTAM MIA3 MIA3 ADTRP ADTRP CTLA4 CTLA4 IRF1 IRF1 IL10 IL10 RC3H2 RC3H2 GLI3 GLI3 FGL1 FGL1 TNR TNR ENSCATP00000026831 ENSCATP00000026831 CEACAM1 CEACAM1 FXYD5 FXYD5 MAD1L1 MAD1L1 PRKG1 PRKG1 ARG1 ARG1 TNFSF4 TNFSF4 PPARA PPARA SMAD7 SMAD7 ZC3H12A ZC3H12A BCL6 BCL6 ENSCATP00000029280 ENSCATP00000029280 IL4R IL4R SCGB1A1 SCGB1A1 SERPINE2 SERPINE2 SHH SHH NOTCH4 NOTCH4 FGG FGG CCL25 CCL25 PTPN22 PTPN22 CTSG CTSG SDC4 SDC4 LOC105591578 LOC105591578 NCKAP1L NCKAP1L LRRC32 LRRC32 VSIG4 VSIG4 BMP6 BMP6 EPB41L5 EPB41L5 JAG1 JAG1 IL1RN IL1RN SWAP70 SWAP70 RUNX1 RUNX1 MAP2K5 MAP2K5 TIGIT TIGIT CDH1 CDH1 CD74 CD74 PRNP PRNP VSIR VSIR SH2B3 SH2B3 ADIPOQ ADIPOQ CLEC4G CLEC4G LGALS7B LGALS7B MDK MDK CD9 CD9 ABCA12 ABCA12 BMP4 BMP4 LOC105594508 LOC105594508 WNK1 WNK1 CBFB CBFB CCL21 CCL21 LAG3 LAG3 ENSCATP00000040503 ENSCATP00000040503 DEF6 DEF6 ENSCATP00000041705 ENSCATP00000041705 BTN2A2 BTN2A2 CD274 CD274 YTHDF2 YTHDF2 IL4I1 IL4I1 TNFRSF21 TNFRSF21 LGALS3 LGALS3 NF2 NF2 HFE HFE BMP2 BMP2 C1QTNF1 C1QTNF1 MARCHF7 MARCHF7 FOXJ1 FOXJ1 RGCC RGCC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOXL3Lysyl oxidase like 3. (753 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
ENSCATP00000001543Ig-like domain-containing protein. (271 aa)
GLMNGlomulin, FKBP associated protein. (594 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
TNFSF18TNF superfamily member 18. (177 aa)
CCL28C-C motif chemokine. (127 aa)
CBLBCbl proto-oncogene B. (1027 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
TBX21T-box transcription factor 21. (535 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
FOXP3Forkhead box P3. (456 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
ASS1Uncharacterized protein. (412 aa)
ARG2Arginase. (417 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
ENSCATP00000003834PTN_MK_N domain-containing protein. (60 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
EPCAMEpithelial cell adhesion molecule. (314 aa)
TMEM131LTransmembrane 131 like. (1610 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1068 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (925 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (273 aa)
RAG2Recombination activating 2. (532 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
ENSCATP00000006016Uncharacterized protein. (661 aa)
KLF4Kruppel like factor 4. (479 aa)
IFNB1Interferon beta 1. (187 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
TARM1T cell-interacting, activating receptor on myeloid cells 1. (224 aa)
AKNAAT-hook transcription factor. (1437 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (432 aa)
ENSCATP00000007363Uncharacterized protein. (150 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
ICOSLGUncharacterized protein. (302 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
NOTCH1Notch receptor 1. (2547 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SPNSialophorin. (405 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
NEXMIFNeurite extension and migration factor. (1516 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
MBPMyelin basic protein. (330 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (522 aa)
HLXH2.0 like homeobox. (494 aa)
TNFRSF14TNF receptor superfamily member 14. (281 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PDE5APhosphodiesterase. (875 aa)
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif 18. (1221 aa)
IFNL1Interferon lambda 1. (202 aa)
ZC3H8Zinc finger CCCH-type containing 8. (298 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (639 aa)
MYADMMyeloid associated differentiation marker. (325 aa)
IL20RBInterleukin 20 receptor subunit beta. (311 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1868 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ANXA1Annexin. (352 aa)
FGL2Fibrinogen like 2. (439 aa)
CD80CD80 molecule. (288 aa)
LOC105591569Galectin. (296 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (509 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (320 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
PLA2G2FPhospholipase A(2). (199 aa)
SCRIBScribble planar cell polarity protein. (1661 aa)
C1QTNF6C1q and TNF related 6. (278 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (403 aa)
ENSCATP00000019334Uncharacterized protein. (425 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
CD86CD86 molecule. (329 aa)
ENSCATP00000019834Uncharacterized protein. (300 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (386 aa)
PLA2G2DPhospholipase A(2). (161 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
ZNF703Zinc finger protein 703. (591 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
PAWRPro-apoptotic WT1 regulator. (340 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
LAX1Lymphocyte transmembrane adaptor 1. (398 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
LOC105592931Uncharacterized protein. (457 aa)
ENSCATP00000023477Uncharacterized protein. (452 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (294 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (212 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (285 aa)
GPNMBGlycoprotein nmb. (561 aa)
CRTAMCytotoxic and regulatory T cell molecule. (393 aa)
MIA3MIA SH3 domain ER export factor 3. (1907 aa)
ADTRPAndrogen dependent TFPI regulating protein. (248 aa)
CTLA4CD152 protein. (223 aa)
IRF1Interferon regulatory factor. (325 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
GLI3GLI family zinc finger 3. (1580 aa)
FGL1Fibrinogen like 1. (272 aa)
TNRTenascin R. (1358 aa)
ENSCATP00000026831Uncharacterized protein. (339 aa)
CEACAM1Uncharacterized protein. (525 aa)
FXYD5FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (180 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (718 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
ARG1Arginase. (322 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
PPARAPeroxisome proliferator activated receptor alpha. (511 aa)
SMAD7Mothers against decapentaplegic homolog. (483 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
BCL6BCL6 transcription repressor. (706 aa)
ENSCATP00000029280Uncharacterized protein. (331 aa)
IL4RInterleukin 4 receptor. (825 aa)
SCGB1A1Secretoglobin family 1A member 1. (91 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
NOTCH4Notch receptor 4. (2000 aa)
FGGFibrinogen gamma chain. (453 aa)
CCL25C-C motif chemokine ligand 25. (172 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (812 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
LOC105591578Galectin. (285 aa)
NCKAP1LNCK associated protein 1 like. (1060 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
VSIG4V-set and immunoglobulin domain containing 4. (404 aa)
BMP6Bone morphogenetic protein 6. (520 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
IL1RNInterleukin-1. (178 aa)
SWAP70Switching B cell complex subunit SWAP70. (585 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (472 aa)
TIGITT cell immunoreceptor with Ig and ITIM domains. (312 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
CD74CD74 molecule. (294 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (267 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
SH2B3SH2B adaptor protein 3. (660 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
LGALS7BGalectin. (136 aa)
MDKMidkine. (143 aa)
CD9Tetraspanin. (228 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
LOC105594508Galectin-7. (136 aa)
WNK1WNK lysine deficient protein kinase 1. (2836 aa)
CBFBCore-binding factor subunit beta. (182 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
LAG3Lymphocyte activating 3. (527 aa)
ENSCATP00000040503FERM domain-containing protein. (476 aa)
DEF6DEF6 guanine nucleotide exchange factor. (631 aa)
ENSCATP00000041705Uncharacterized protein. (296 aa)
BTN2A2Uncharacterized protein. (519 aa)
CD274CD274 molecule. (290 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (583 aa)
IL4I1Amine oxidase. (589 aa)
TNFRSF21TNF receptor superfamily member 21. (655 aa)
LGALS3Galectin. (248 aa)
NF2Neurofibromin 2. (595 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
C1QTNF1C1q and TNF related 1. (281 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (704 aa)
FOXJ1Forkhead box J1. (421 aa)
RGCCRegulator of cell cycle. (137 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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