STRINGSTRING
ENSCATP00000036371 ENSCATP00000036371 CTSH CTSH ADAMTSL2 ADAMTSL2 EPAS1 EPAS1 LOX LOX SREBF1 SREBF1 ABCA12 ABCA12 BMP4 BMP4 HSD11B1 HSD11B1 FGF7 FGF7 SPRY1 SPRY1 EP300 EP300 LTA4H LTA4H KLF2 KLF2 RCN3 RCN3 HOXA5 HOXA5 GLI1 GLI1 NKX2-8 NKX2-8 IGFBP5 IGFBP5 NKIRAS2 NKIRAS2 NUMA1 NUMA1 AARD AARD EXT1 EXT1 LHX3 LHX3 PDGFRB PDGFRB CCDC40 CCDC40 FOXJ1 FOXJ1 WNT7B WNT7B ENSCATP00000000240 ENSCATP00000000240 LOXL3 LOXL3 NOG NOG DPPA4 DPPA4 ATXN1L ATXN1L MMP14 MMP14 PDGFA PDGFA FGF2 FGF2 SMAD2 SMAD2 GATA6 GATA6 TMEM38B TMEM38B EIF4G1 EIF4G1 THRA THRA LAMA5 LAMA5 ATP7A ATP7A SELENON SELENON ENSCATP00000004894 ENSCATP00000004894 CRH CRH ENSCATP00000005258 ENSCATP00000005258 ABCA3 ABCA3 FNDC3B FNDC3B SPDEF SPDEF SOX11 SOX11 RDH10 RDH10 SLC23A1 SLC23A1 ITGA3 ITGA3 CTSZ CTSZ NOTCH1 NOTCH1 GRHL2 GRHL2 TGFB3 TGFB3 ADAMTS2 ADAMTS2 KDR KDR TGFB1 TGFB1 SP3 SP3 LIPA LIPA SLC7A11 SLC7A11 FGF9 FGF9 ESRP2 ESRP2 ENSCATP00000010398 ENSCATP00000010398 MAPK3 MAPK3 KRAS KRAS CCBE1 CCBE1 TBX5 TBX5 RSPO2 RSPO2 PPP1CA PPP1CA SIM2 SIM2 COL3A1 COL3A1 LTBP3 LTBP3 ENSCATP00000014838 ENSCATP00000014838 MYOCD MYOCD ZFPM2 ZFPM2 PHEX PHEX AIMP2 AIMP2 ENSCATP00000015541 ENSCATP00000015541 MAPK1 MAPK1 WNT5A WNT5A FGF8 FGF8 HIKESHI HIKESHI ELK1 ELK1 FGF1 FGF1 MMP12 MMP12 HMGCS2 HMGCS2 LAMA1 LAMA1 ASCL1 ASCL1 DLG5 DLG5 ENSCATP00000017436 ENSCATP00000017436 SEC24B SEC24B DNAAF1 DNAAF1 FOXF1 FOXF1 HOPX HOPX PKD1 PKD1 JMJD6 JMJD6 SRF SRF BMPR2 BMPR2 TTC25 TTC25 BMPR1A BMPR1A LOC105575095 LOC105575095 ENSCATP00000019707 ENSCATP00000019707 EDN2 EDN2 SPRY2 SPRY2 HS6ST1 HS6ST1 DAG1 DAG1 ASXL1 ASXL1 PKDCC PKDCC STRA6 STRA6 CTNNB1 CTNNB1 GLI2 GLI2 HHIP HHIP SMPD3 SMPD3 FLT4 FLT4 HEG1 HEG1 MAN1A2 MAN1A2 YAP1 YAP1 RBBP9 RBBP9 NFIB NFIB RIDA RIDA CCN2 CCN2 CHI3L1 CHI3L1 TIMELESS TIMELESS WNT11 WNT11 BAG6 BAG6 PPP3R1 PPP3R1 ERRFI1 ERRFI1 FBXW9 FBXW9 THRB THRB ZIC3 ZIC3 CELSR1 CELSR1 RC3H2 RC3H2 GLI3 GLI3 LIF LIF PHF14 PHF14 SFTPD SFTPD CREB1 CREB1 EIF4E EIF4E TCF21 TCF21 TBX4 TBX4 ARG1 ARG1 PTK7 PTK7 ACVR2B ACVR2B FGFR2 FGFR2 ADA ADA AGR2 AGR2 NODAL NODAL TBX2 TBX2 ITGB6 ITGB6 AP3B1 AP3B1 PLOD3 PLOD3 NKX2-1 NKX2-1 SAV1 SAV1 SHH SHH PROX1 PROX1 FGF10 FGF10 CLCN2 CLCN2 ENSCATP00000032281 ENSCATP00000032281 STK40 STK40 CRISPLD2 CRISPLD2 MAN2A1 MAN2A1 FOXA1 FOXA1 CCDC39 CCDC39 PDPN PDPN WNT2 WNT2 TGFBR2 TGFBR2 FBXW7 FBXW7 NOS3 NOS3 FGF18 FGF18 HSPB11 HSPB11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCATP00000036371A_deaminase domain-containing protein. (346 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
ADAMTSL2ADAMTS like 2. (1054 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
LOXLysyl oxidase. (417 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HSD11B1Hydroxysteroid 11-beta dehydrogenase 1. (292 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
EP300E1A binding protein p300. (2411 aa)
LTA4HLeukotriene A4 hydrolase. (587 aa)
KLF2Kruppel like factor 2. (355 aa)
RCN3Reticulocalbin 3. (328 aa)
HOXA5Homeobox A5. (270 aa)
GLI1GLI family zinc finger 1. (1106 aa)
NKX2-8NK2 homeobox 8. (236 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (198 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2098 aa)
AARDAlanine and arginine rich domain containing protein. (155 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
LHX3LIM homeobox 3. (402 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CCDC40Coiled-coil domain containing 40. (1129 aa)
FOXJ1Forkhead box J1. (421 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
ENSCATP00000000240Uncharacterized protein. (130 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DPPA4Developmental pluripotency associated 4. (301 aa)
ATXN1LAtaxin 1 like. (689 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
GATA6GATA binding protein 6. (595 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1604 aa)
THRAThyroid hormone receptor alpha. (602 aa)
LAMA5Laminin subunit alpha 5. (3673 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
SELENONSelenoprotein N. (552 aa)
ENSCATP00000004894ETS domain-containing protein. (421 aa)
CRHCorticotropin releasing hormone. (196 aa)
ENSCATP00000005258Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (294 aa)
ABCA3ATP binding cassette subfamily A member 3. (1704 aa)
FNDC3BFibronectin type III domain containing 3B. (1158 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
SOX11Transcription factor SOX. (441 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
SLC23A1Solute carrier family 23 member 1. (598 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
NOTCH1Notch receptor 1. (2547 aa)
GRHL2Grainyhead like transcription factor 2. (630 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2. (1209 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SP3Sp3 transcription factor. (780 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (408 aa)
SLC7A11Solute carrier family 7 member 11. (519 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ESRP2Epithelial splicing regulatory protein 2. (715 aa)
ENSCATP00000010398ABC transporter domain-containing protein. (194 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
TBX5T-box transcription factor 5. (518 aa)
RSPO2R-spondin 2. (243 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
SIM2SIM bHLH transcription factor 2. (667 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1298 aa)
ENSCATP00000014838ETS domain-containing protein. (418 aa)
MYOCDMyocardin. (979 aa)
ZFPM2Zinc finger protein, FOG family member 2. (992 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (749 aa)
AIMP2Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (320 aa)
ENSCATP00000015541Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (462 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (382 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
ELK1ETS domain-containing protein. (428 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
LAMA1Laminin subunit alpha 1. (3079 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (228 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1868 aa)
ENSCATP00000017436ETS domain-containing protein. (394 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1261 aa)
DNAAF1Dynein assembly factor 1, axonemal. (612 aa)
FOXF1Forkhead box F1. (380 aa)
HOPXHOP homeobox. (98 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4298 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (420 aa)
SRFSerum response factor. (508 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (997 aa)
TTC25Tetratricopeptide repeat domain 25. (671 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOC105575095HOP homeobox. (73 aa)
ENSCATP00000019707Uncharacterized protein. (93 aa)
EDN2Endothelin 2. (178 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
DAG1Dystroglycan 1. (894 aa)
ASXL1ASXL transcriptional regulator 1. (1542 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
STRA6Stimulated by retinoic acid 6. (707 aa)
CTNNB1Catenin beta 1. (781 aa)
GLI2GLI family zinc finger 2. (1586 aa)
HHIPHedgehog interacting protein. (682 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
HEG1Heart development protein with EGF like domains 1. (1380 aa)
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (641 aa)
YAP1Yes associated protein 1. (508 aa)
RBBP9Uncharacterized protein. (186 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
RIDAUncharacterized protein. (137 aa)
CCN2Cellular communication network factor 2. (349 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (383 aa)
TIMELESSTimeless circadian regulator. (1208 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
BAG6BCL2 associated athanogene 6. (1126 aa)
PPP3R1Uncharacterized protein. (189 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
THRBThyroid hormone receptor beta. (476 aa)
ZIC3Zic family member 3. (466 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2773 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
GLI3GLI family zinc finger 3. (1580 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
PHF14PHD finger protein 14. (947 aa)
SFTPDSurfactant protein D. (375 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
EIF4EEukaryotic translation initiation factor 4E. (247 aa)
TCF21Transcription factor 21. (179 aa)
TBX4T-box transcription factor 4. (545 aa)
ARG1Arginase. (322 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
ADAA_deaminase domain-containing protein. (449 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
NODALNodal growth differentiation factor. (347 aa)
TBX2T-box transcription factor 2. (588 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (737 aa)
NKX2-1NK2 homeobox 1. (370 aa)
SAV1Salvador family WW domain containing protein 1. (412 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
PROX1Prospero homeobox 1. (737 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CLCN2Chloride channel protein. (898 aa)
ENSCATP00000032281Uncharacterized protein. (203 aa)
STK40Serine/threonine kinase 40. (435 aa)
CRISPLD2Cysteine rich secretory protein LCCL domain containing 2. (497 aa)
MAN2A1Alpha-mannosidase. (1144 aa)
FOXA1Forkhead box A1. (470 aa)
CCDC39Coiled-coil domain containing 39. (1010 aa)
PDPNPodoplanin. (206 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
HSPB11Heat shock protein family B (small) member 11. (144 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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