(21 nodes) Preribosome, large subunit precursor network (Cercocebus atys)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	ENSCATP00000024305	WD_REPEATS_REGION domain-containing protein. (389 aa)
	RRP1	Ribosomal RNA processing 1. (478 aa)
	RRS1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
	RRP1B	Ribosomal RNA processing 1B. (758 aa)
	RRP15	Ribosomal RNA processing 15 homolog. (285 aa)
	NSA2	NSA2 ribosome biogenesis factor. (260 aa)
	PES1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (590 aa)
	ENSCATP00000012673	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (217 aa)
	MAK16	Protein MAK16 homolog; Belongs to the MAK16 family. (300 aa)
	ENSCATP00000013346	Uncharacterized protein. (196 aa)
	ZNF622	Zinc finger protein 622. (477 aa)
	EBNA1BP2	EBNA1 binding protein 2. (422 aa)
	BOP1	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (746 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (269 aa)
	LAS1L	LAS1 like, ribosome biogenesis factor. (739 aa)
	NOC2L	NOC2 like nucleolar associated transcriptional repressor. (720 aa)
	WDR74	WD repeat domain 74. (385 aa)
	MDN1	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5597 aa)
	ENSCATP00000037306	Uncharacterized protein. (235 aa)
	ENSCATP00000030878	Uncharacterized protein. (238 aa)
	WDR12	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (425 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOP1	EBNA1BP2	ENSCATP00000017060	ENSCATP00000028990	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	EBNA1 binding protein 2.	0.996
BOP1	EIF6	ENSCATP00000017060	ENSCATP00000017071	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...]	0.960
BOP1	ENSCATP00000012673	ENSCATP00000017060	ENSCATP00000012673	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.992
BOP1	ENSCATP00000013346	ENSCATP00000017060	ENSCATP00000013346	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.956
BOP1	ENSCATP00000024305	ENSCATP00000017060	ENSCATP00000024305	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	WD_REPEATS_REGION domain-containing protein.	0.993
BOP1	ENSCATP00000030878	ENSCATP00000017060	ENSCATP00000030878	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.956
BOP1	ENSCATP00000037306	ENSCATP00000017060	ENSCATP00000037306	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.956
BOP1	LAS1L	ENSCATP00000017060	ENSCATP00000019318	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	LAS1 like, ribosome biogenesis factor.	0.735
BOP1	MAK16	ENSCATP00000017060	ENSCATP00000012834	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.972
BOP1	MDN1	ENSCATP00000017060	ENSCATP00000045197	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family.	0.604
BOP1	NOC2L	ENSCATP00000017060	ENSCATP00000021803	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	NOC2 like nucleolar associated transcriptional repressor.	0.995
BOP1	NSA2	ENSCATP00000017060	ENSCATP00000008683	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	NSA2 ribosome biogenesis factor.	0.956
BOP1	PES1	ENSCATP00000017060	ENSCATP00000027123	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family.	0.999
BOP1	RRP1	ENSCATP00000017060	ENSCATP00000004465	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosomal RNA processing 1.	0.974
BOP1	RRP15	ENSCATP00000017060	ENSCATP00000006991	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosomal RNA processing 15 homolog.	0.950
BOP1	RRP1B	ENSCATP00000017060	ENSCATP00000005237	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosomal RNA processing 1B.	0.974
BOP1	RRS1	ENSCATP00000017060	ENSCATP00000005017	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.865
BOP1	WDR12	ENSCATP00000017060	ENSCATP00000023951	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.995
BOP1	WDR74	ENSCATP00000017060	ENSCATP00000022883	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	WD repeat domain 74.	0.996
BOP1	ZNF622	ENSCATP00000017060	ENSCATP00000014435	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Zinc finger protein 622.	0.470