STRINGSTRING
DBN1 DBN1 FCHSD2 FCHSD2 PIK3R2 PIK3R2 ARPC4 ARPC4 TMSB15A TMSB15A PRKCD PRKCD CSF3 CSF3 CRACD CRACD ARPC1A ARPC1A ARHGAP40 ARHGAP40 COTL1 COTL1 ENSCATP00000019774 ENSCATP00000019774 SCIN SCIN BAIAP2L1 BAIAP2L1 NPHS1 NPHS1 SNX9 SNX9 PTK2B PTK2B TWF1 TWF1 ARPC2 ARPC2 LOC105571637 LOC105571637 CAPZA1 CAPZA1 LMOD2 LMOD2 BBS4 BBS4 ARFGEF1 ARFGEF1 TMOD4 TMOD4 CAPZB CAPZB PFN4 PFN4 GBA2 GBA2 SSH2 SSH2 MKKS MKKS MYADM MYADM CDC42EP3 CDC42EP3 MTPN MTPN ELN ELN CARMIL2 CARMIL2 HIP1R HIP1R NCK1 NCK1 IQANK1 IQANK1 MLST8 MLST8 ABITRAM ABITRAM DBNL DBNL TRIOBP TRIOBP KIRREL1 KIRREL1 TMOD3 TMOD3 PFN1 PFN1 LOC105574300 LOC105574300 LOC105596959 LOC105596959 SPTBN5 SPTBN5 NCKAP1 NCKAP1 LOC105596948 LOC105596948 BAG4 BAG4 CAPZA3 CAPZA3 ADD1 ADD1 ENSCATP00000006802 ENSCATP00000006802 FMN1 FMN1 CDC42EP5 CDC42EP5 C15orf62 C15orf62 FAM49A FAM49A CDC42EP2 CDC42EP2 VILL VILL GSN GSN TENM1 TENM1 ARF6 ARF6 SPTA1 SPTA1 ENSCATP00000003424 ENSCATP00000003424 ARHGAP28 ARHGAP28 PFN3 PFN3 PLEKHG2 PLEKHG2 LMOD3 LMOD3 PFN2 PFN2 ARHGAP18 ARHGAP18 RASA1 RASA1 CAPG CAPG BIN1 BIN1 SSH1 SSH1 VIL1 VIL1 EPS8 EPS8 ENSCATP00000005099 ENSCATP00000005099 DLG1 DLG1 LATS1 LATS1 KANK4 KANK4 ENSCATP00000026922 ENSCATP00000026922 HAX1 HAX1 PAK3 PAK3 ARPC1B ARPC1B ENSCATP00000027915 ENSCATP00000027915 ARPC5L ARPC5L SPTBN2 SPTBN2 CYFIP2 CYFIP2 CORO1A CORO1A ARPC5 ARPC5 ENSCATP00000029599 ENSCATP00000029599 ALOX15 ALOX15 CTTN CTTN SPTAN1 SPTAN1 NCK2 NCK2 TMOD2 TMOD2 FHOD3 FHOD3 LMOD1 LMOD1 PYCARD PYCARD SSH3 SSH3 NCKAP1L NCKAP1L TMSB10 TMSB10 ARPC3 ARPC3 CAPZA2 CAPZA2 ENSCATP00000034499 ENSCATP00000034499 CYFIP1 CYFIP1 SPTBN4 SPTBN4 MTOR MTOR ENSCATP00000035938 ENSCATP00000035938 PRKCE PRKCE DAAM2 DAAM2 ENSCATP00000036494 ENSCATP00000036494 CCL24 CCL24 HCLS1 HCLS1 CCR7 CCR7 DMTN DMTN FER FER BAIAP2L2 BAIAP2L2 BAIAP2 BAIAP2 KANK1 KANK1 FLII FLII TWF2 TWF2 CCL21 CCL21 ENSCATP00000040503 ENSCATP00000040503 VASP VASP RICTOR RICTOR AVIL AVIL ENSCATP00000041372 ENSCATP00000041372 TMOD1 TMOD1 FAM49B FAM49B LOC105576025 LOC105576025 CDC42EP1 CDC42EP1 ENSCATP00000042587 ENSCATP00000042587 GRB2 GRB2 SLIT2 SLIT2 KANK3 KANK3 ENSCATP00000043705 ENSCATP00000043705 FCHSD1 FCHSD1 SPTBN1 SPTBN1 ADD2 ADD2 ADD3 ADD3 SPTB SPTB CCL26 CCL26 CARMIL1 CARMIL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DBN1Drebrin 1. (696 aa)
FCHSD2FCH and double SH3 domains 2. (764 aa)
PIK3R2Uncharacterized protein. (624 aa)
ARPC4Actin related protein 2/3 complex subunit 4. (290 aa)
TMSB15AThymosin beta 15a. (45 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CSF3Colony stimulating factor 3. (204 aa)
CRACDKIAA1211. (1226 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARHGAP40Rho GTPase activating protein 40. (567 aa)
COTL1Coactosin like F-actin binding protein 1. (142 aa)
ENSCATP00000019774Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (139 aa)
SCINScinderin. (706 aa)
BAIAP2L1BAI1 associated protein 2 like 1. (511 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1226 aa)
SNX9Sorting nexin. (596 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
TWF1Twinfilin actin binding protein 1. (391 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
LOC105571637Thymosin beta-15A. (45 aa)
CAPZA1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
LMOD2Leiomodin 2. (552 aa)
BBS4Bardet-Biedl syndrome 4. (347 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1852 aa)
TMOD4Tropomodulin 4. (345 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (301 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (927 aa)
SSH2Slingshot protein phosphatase 2. (1450 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
MYADMMyeloid associated differentiation marker. (325 aa)
CDC42EP3CDC42 effector protein 3. (254 aa)
MTPNMyotrophin. (118 aa)
ELNElastin. (667 aa)
CARMIL2Capping protein regulator and myosin 1 linker 2. (1435 aa)
HIP1RHuntingtin interacting protein 1 related. (1068 aa)
NCK1Cytoplasmic protein. (377 aa)
IQANK1IQ motif and ankyrin repeat containing 1. (564 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
ABITRAMActin binding transcription modulator. (180 aa)
DBNLDrebrin like. (440 aa)
TRIOBPTRIO and F-actin binding protein. (2270 aa)
KIRREL1Kirre like nephrin family adhesion molecule 1. (757 aa)
TMOD3Tropomodulin 3. (352 aa)
PFN1Profilin; Belongs to the profilin family. (167 aa)
LOC105574300Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
LOC105596959HP domain-containing protein. (81 aa)
SPTBN5Spectrin beta, non-erythrocytic 5. (3725 aa)
NCKAP1NCK associated protein 1. (1134 aa)
LOC105596948Supervillin. (2177 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
CAPZA3F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (299 aa)
ADD1Adducin 1. (768 aa)
ENSCATP00000006802Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (162 aa)
FMN1Formin 1. (1425 aa)
CDC42EP5CDC42 effector protein 5. (148 aa)
C15orf62Chromosome 15 open reading frame 62. (175 aa)
FAM49AFamily with sequence similarity 49 member A. (323 aa)
CDC42EP2Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (210 aa)
VILLVillin like. (855 aa)
GSNGelsolin. (809 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2420 aa)
ENSCATP00000003424HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
ARHGAP28Rho GTPase activating protein 28. (729 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
PLEKHG2Pleckstrin homology and RhoGEF domain containing G2. (1388 aa)
LMOD3Leiomodin 3. (559 aa)
PFN2Profilin; Belongs to the profilin family. (191 aa)
ARHGAP18Rho GTPase activating protein 18. (663 aa)
RASA1RAS p21 protein activator 1. (1051 aa)
CAPGCapping actin protein, gelsolin like. (348 aa)
BIN1Bridging integrator 1. (608 aa)
SSH1Slingshot protein phosphatase 1. (1122 aa)
VIL1Villin 1. (830 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (842 aa)
ENSCATP00000005099Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (161 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (925 aa)
LATS1Large tumor suppressor kinase 1. (1179 aa)
KANK4KN motif and ankyrin repeat domains 4. (993 aa)
ENSCATP00000026922Uncharacterized protein. (85 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
ENSCATP00000027915Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (143 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (159 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2390 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (519 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ENSCATP00000029599WD_REPEATS_REGION domain-containing protein. (334 aa)
ALOX15Lipoxygenase domain-containing protein. (325 aa)
CTTNCortactin. (550 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2498 aa)
NCK2Cytoplasmic protein. (382 aa)
TMOD2Tropomodulin 2. (341 aa)
FHOD3Formin homology 2 domain containing 3. (1622 aa)
LMOD1Leiomodin 1. (600 aa)
PYCARDPYD and CARD domain containing. (195 aa)
SSH3Slingshot protein phosphatase 3. (657 aa)
NCKAP1LNCK associated protein 1 like. (1060 aa)
TMSB10Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (182 aa)
CAPZA2F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (268 aa)
ENSCATP00000034499Uncharacterized protein. (159 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1239 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (2565 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ENSCATP00000035938Uncharacterized protein. (60 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1077 aa)
ENSCATP00000036494F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (238 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (476 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
DMTNDematin actin binding protein. (406 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
BAIAP2L2BAI1 associated protein 2 like 2. (529 aa)
BAIAP2BAI1 associated protein 2. (561 aa)
KANK1KN motif and ankyrin repeat domains 1. (1352 aa)
FLIIFLII actin remodeling protein. (1269 aa)
TWF2Twinfilin actin binding protein 2. (336 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
ENSCATP00000040503FERM domain-containing protein. (476 aa)
VASPVasodilator stimulated phosphoprotein. (431 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
AVILAdvillin. (819 aa)
ENSCATP00000041372Profilin; Belongs to the profilin family. (91 aa)
TMOD1Tropomodulin 1. (365 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
LOC105576025F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (267 aa)
CDC42EP1CDC42 effector protein 1. (370 aa)
ENSCATP00000042587Uncharacterized protein. (62 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
KANK3KN motif and ankyrin repeat domains 3. (830 aa)
ENSCATP00000043705Uncharacterized protein. (238 aa)
FCHSD1FCH and double SH3 domains 1. (722 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2366 aa)
ADD2Adducin 2. (726 aa)
ADD3Adducin 3. (706 aa)
SPTBSpectrin beta chain; Belongs to the spectrin family. (2326 aa)
CCL26C-C motif chemokine. (94 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1424 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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