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| | SLC26A1 | Sulfate anion transporter 1; Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (701 aa) |
| | ACSL6 | AMP-binding domain-containing protein. (722 aa) |
| | ACLY | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1155 aa) |
| | ELOVL2 | Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (296 aa) |
| | SULT1B1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (299 aa) |
| | NUDT19 | Nudix hydrolase 19. (360 aa) |
| | BAAT | Bile acid-CoA:amino acid N-acyltransferase. (418 aa) |
| | LOC105573378 | Uncharacterized protein. (416 aa) |
| | PPCDC | Phosphopantothenoylcysteine decarboxylase. (221 aa) |
| | TPST1 | Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family. (370 aa) |
| | TDO2 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa) |
| | PIPOX | Pipecolic acid and sarcosine oxidase. (390 aa) |
| | SUCLG1 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (925 aa) |
| | ACSBG2 | Acyl-CoA synthetase bubblegum family member 2. (666 aa) |
| | PDHB | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa) |
| | MCEE | VOC domain-containing protein. (173 aa) |
| | COASY | Coenzyme A synthase. (564 aa) |
| | LOC105572016 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (503 aa) |
| | ELOVL7 | Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (281 aa) |
| | PANK1 | Pantothenate kinase 1. (598 aa) |
| | PANK4 | 4'-phosphopantetheine phosphatase; May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'- phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway. (781 aa) |
| | ACSM1 | Acyl-CoA synthetase medium chain family member 1. (475 aa) |
| | ACSS1 | Acetyl-coenzyme A synthetase. (688 aa) |
| | PANK3 | Pantothenate kinase 3. (370 aa) |
| | ACACB | Acetyl-CoA carboxylase beta. (2458 aa) |
| | ACSS2 | Acyl-CoA synthetase short chain family member 2. (714 aa) |
| | HMGCS1 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa) |
| | GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial. (815 aa) |
| | OXSM | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (460 aa) |
| | DCAKD | Dephospho-CoA kinase domain containing. (231 aa) |
| | HMGCS2 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa) |
| | MVD | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (401 aa) |
| | ACOT9 | Acyl-CoA thioesterase 9. (433 aa) |
| | CROT | Carnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family. (612 aa) |
| | MCCC2 | Methylcrotonoyl-CoA carboxylase 2. (563 aa) |
| | LOC105579993 | VOC domain-containing protein. (170 aa) |
| | PDHX | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa) |
| | NUDT7 | Nudix hydrolase 7. (238 aa) |
| | ACOT6 | Acyl-CoA thioesterase 6. (207 aa) |
| | ACSM5 | Acyl-CoA synthetase medium chain family member 5. (580 aa) |
| | CCDC30 | Coiled-coil domain containing 30. (783 aa) |
| | HSD17B4 | Hydroxysteroid 17-beta dehydrogenase 4. (757 aa) |
| | SULT2A1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (264 aa) |
| | ACOT8 | Acyl-CoA thioesterase 8. (319 aa) |
| | ENSCATP00000033897 | Uncharacterized protein. (324 aa) |
| | SULT1C3 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (304 aa) |
| | DGAT1 | O-acyltransferase. (491 aa) |
| | ELOVL5 | Elongation of very long chain fatty acids protein. (326 aa) |
| | ACOT12 | Acyl-CoA thioesterase 12. (555 aa) |
| | SULT1E1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (294 aa) |
| | SULT2B1 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (355 aa) |
| | ABCD1 | ATP binding cassette subfamily D member 1. (740 aa) |
| | ACOT7 | Acyl-CoA thioesterase 7. (387 aa) |
| | TECR | S5A_REDUCTASE domain-containing protein. (315 aa) |
| | ELOVL6 | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa) |
| | OGDH | Oxoglutarate dehydrogenase. (1038 aa) |
| | PMVK | Phosphomevalonate kinase. (192 aa) |
| | MLYCD | Malonyl-CoA decarboxylase. (493 aa) |
| | PANK2 | Uncharacterized protein. (279 aa) |
| | FITM2 | Fat storage inducing transmembrane protein 2. (262 aa) |
| | ELOVL4 | Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (314 aa) |
| | ACOT11 | Acyl-CoA thioesterase 11. (533 aa) |
| | PDHA1 | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (428 aa) |
| | THEM5 | Thioesterase superfamily member 5. (246 aa) |
| | ACSL4 | Acyl-CoA synthetase long chain family member 4. (711 aa) |
| | HACD1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (288 aa) |
| | MPC2 | Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa) |
| | ELOVL3 | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa) |
| | NUDT8 | Nudix hydrolase 8. (236 aa) |
| | ACOT4 | Uncharacterized protein. (426 aa) |
| | ENSCATP00000011155 | S5A_REDUCTASE domain-containing protein. (273 aa) |
| | ACAT1 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa) |
| | HDDC3 | HD domain containing 3. (179 aa) |
| | DLAT | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa) |
| | ACSL1 | Acyl-CoA synthetase long chain family member 1. (698 aa) |
| | PAPSS1 | 3'-phosphoadenosine 5'-phosphosulfate synthase 1. (624 aa) |
| | ENSCATP00000025033 | Uncharacterized protein. (318 aa) |
| | ACACA | Acetyl-CoA carboxylase alpha. (2389 aa) |
| | PPT2 | Palmitoyl-protein thioesterase 2. (302 aa) |
| | HTD2 | Hydroxyacyl-thioester dehydratase type 2. (162 aa) |
| | DIP2A | Disco interacting protein 2 homolog A. (1581 aa) |
| | ELOVL1 | Elongation of very long chain fatty acids protein. (286 aa) |
| | AASS | Aminoadipate-semialdehyde synthase. (925 aa) |
| | PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2. (619 aa) |
| | LOC105586584 | Uncharacterized protein. (577 aa) |
| | DLST | Dihydrolipoamide S-succinyltransferase. (454 aa) |
| | PPCS | Phosphopantothenoylcysteine synthetase. (311 aa) |
| | DGAT2 | Diacylglycerol O-acyltransferase 2. (388 aa) |
| | FAR2 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (515 aa) |
| | MVK | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (418 aa) |
| | SLC25A16 | Solute carrier family 25 member 16; Belongs to the mitochondrial carrier (TC 2.A.29) family. (331 aa) |
| | AADAT | Aminoadipate aminotransferase. (425 aa) |
| | SULT1C4 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (302 aa) |
| | ACSL5 | Acyl-CoA synthetase long chain family member 5. (683 aa) |
| | SLC26A2 | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (739 aa) |
| | SUCLG2 | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (437 aa) |
| | BPNT1 | 3'(2'), 5'-bisphosphate nucleotidase 1. (308 aa) |
| | GLYAT | Glycine-N-acyltransferase. (296 aa) |
| | PDHA2 | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (388 aa) |
| | HMGCR | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa) |
