STRINGSTRING
IMPACT IMPACT NCF1 NCF1 ZNF580 ZNF580 PLEKHA1 PLEKHA1 MAP1LC3A MAP1LC3A MAPK8 MAPK8 LOC105587688 LOC105587688 LOC105584272 LOC105584272 LOC105587685 LOC105587685 MMP2 MMP2 ATP7A ATP7A SRC SRC CYP1B1 CYP1B1 AQP1 AQP1 NET1 NET1 GLRX2 GLRX2 MAP3K5 MAP3K5 ROMO1 ROMO1 AKT1 AKT1 MAPK13 MAPK13 RHOB RHOB SOD3 SOD3 AIFM1 AIFM1 NQO1 NQO1 AKR1C3 AKR1C3 ENSCATP00000010748 ENSCATP00000010748 MMP9 MMP9 MAPK3 MAPK3 AXL AXL ZNF277 ZNF277 PPARGC1B PPARGC1B PDCD10 PDCD10 EDN1 EDN1 FANCC FANCC FXN FXN MPV17 MPV17 MAPK1 MAPK1 PARK7 PARK7 PDK2 PDK2 ABL1 ABL1 RNF112 RNF112 RIPK1 RIPK1 NME8 NME8 CAMKK2 CAMKK2 OSER1 OSER1 AMBP AMBP MAPK9 MAPK9 BTK BTK MAPK7 MAPK7 CAT CAT TRPM2 TRPM2 PRKCD PRKCD PTPRK PTPRK FABP1 FABP1 FYN FYN SMPD3 SMPD3 RPS3 RPS3 PJVK PJVK ENSCATP00000024192 ENSCATP00000024192 HSF1 HSF1 EZH2 EZH2 IL18BP IL18BP PRDX5 PRDX5 LOC105580111 LOC105580111 NFE2L2 NFE2L2 AGAP3 AGAP3 ARG1 ARG1 LOC105572493 LOC105572493 CRYGD CRYGD SLC8A1 SLC8A1 ENSCATP00000031549 ENSCATP00000031549 UCP1 UCP1 ECT2 ECT2 ERCC6L2 ERCC6L2 MPO MPO EGFR EGFR SPHK1 SPHK1 ANKZF1 ANKZF1 SIGMAR1 SIGMAR1 PAX2 PAX2 NOS3 NOS3 STAT6 STAT6 ERN1 ERN1 SOD1 SOD1 SIRT1 SIRT1 RELA RELA PPIF PPIF ENSCATP00000036866 ENSCATP00000036866 IL6 IL6 TNFAIP3 TNFAIP3 FER FER SOD2 SOD2 ENSCATP00000038390 ENSCATP00000038390 MT3 MT3 PCGF2 PCGF2 ENSCATP00000038840 ENSCATP00000038840 TRPA1 TRPA1 RIPK3 RIPK3 HDAC2 HDAC2 ADPRHL2 ADPRHL2 PRDX1 PRDX1 SETX SETX HDAC6 HDAC6 PKD2 PKD2 KLF2 KLF2 MAPK10 MAPK10 KDM6B KDM6B CHUK CHUK ENSCATP00000042935 ENSCATP00000042935 SIRPA SIRPA CCS CCS STK25 STK25 PXN PXN FOS FOS BNIP3 BNIP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IMPACTImpact RWD domain protein. (320 aa)
NCF1Neutrophil cytosolic factor 1. (423 aa)
ZNF580Zinc finger protein 580. (172 aa)
PLEKHA1Pleckstrin homology domain containing A1. (362 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (125 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
LOC105587688Aldo_ket_red domain-containing protein. (323 aa)
LOC105584272KH type-2 domain-containing protein. (164 aa)
LOC105587685Aldo-keto reductase family 1 member C1. (275 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
SRCTyrosine-protein kinase. (644 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (547 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (296 aa)
NET1Neuroepithelial cell transforming 1. (596 aa)
GLRX2Glutaredoxin 2. (174 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
RHOBRas homolog family member B. (196 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (240 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
AKR1C3Aldo-keto reductase family 1 member C3. (274 aa)
ENSCATP00000010748Thioredoxin domain-containing protein. (193 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
ZNF277Zinc finger protein 277. (456 aa)
PPARGC1BPPARG coactivator 1 beta. (1019 aa)
PDCD10Programmed cell death 10. (212 aa)
EDN1Endothelin 1. (211 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
FXNFrataxin. (210 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (187 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PARK7DJ-1_PfpI domain-containing protein. (198 aa)
PDK2Protein-serine/threonine kinase. (616 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
RNF112Ring finger protein 112. (631 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
NME8NME/NM23 family member 8. (588 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
OSER1Oxidative stress responsive serine rich 1. (292 aa)
AMBPAlpha-1-microglobulin/bikunin precursor. (352 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
BTKTyrosine-protein kinase. (659 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1542 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1439 aa)
FABP1Fatty acid binding protein 1. (122 aa)
FYNTyrosine-protein kinase. (537 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (268 aa)
PJVKPejvakin. (352 aa)
ENSCATP00000024192DJ-1_PfpI domain-containing protein. (150 aa)
HSF1Heat shock transcription factor 1. (532 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
IL18BPInterleukin 18 binding protein. (192 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (215 aa)
LOC105580111Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (174 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
AGAP3ArfGAP with GTPase domain, ankyrin repeat and PH domain 3. (913 aa)
ARG1Arginase. (322 aa)
LOC105572493KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (242 aa)
CRYGDCrystallin gamma D; Belongs to the beta/gamma-crystallin family. (174 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
ENSCATP00000031549DJ-1_PfpI domain-containing protein. (131 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
ECT2Epithelial cell transforming 2. (917 aa)
ERCC6L2Uncharacterized protein. (1455 aa)
MPOMyeloperoxidase. (797 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
SPHK1Sphingosine kinase 1. (470 aa)
ANKZF1Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (739 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
PAX2Paired box 2. (417 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
STAT6Signal transducer and activator of transcription. (737 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
SOD1Superoxide dismutase 1. (154 aa)
SIRT1Sirtuin 1. (744 aa)
RELARELA proto-oncogene, NF-kB subunit. (550 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (211 aa)
ENSCATP00000036866Uncharacterized protein. (55 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (214 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (232 aa)
ENSCATP00000038390Uncharacterized protein. (144 aa)
MT3Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
ENSCATP000000388401-cysPrx_C domain-containing protein. (94 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1144 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (364 aa)
PRDX1Peroxiredoxin 1. (199 aa)
SETXSenataxin. (2653 aa)
HDAC6Histone deacetylase 6. (1217 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (969 aa)
KLF2Kruppel like factor 2. (355 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
KDM6BLysine demethylase 6B. (1689 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ENSCATP00000042935Ribosomal_S3_C domain-containing protein. (236 aa)
SIRPAUncharacterized protein. (507 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
STK25Serine/threonine kinase 25. (426 aa)
PXNPaxillin. (1082 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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