22 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DDB2	Damage specific DNA binding protein 2. (427 aa)
	LOC105584067	RING-type domain-containing protein. (334 aa)
	PCGF3	Polycomb group ring finger 3. (242 aa)
	SKP1	S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa)
	PCGF6	Polycomb group ring finger 6. (350 aa)
	PCGF2	Polycomb group ring finger 2. (344 aa)
	TRIM37	Tripartite motif containing 37. (947 aa)
	BARD1	BRCA1 associated RING domain 1. (777 aa)
	DDB1	Damage specific DNA binding protein 1. (1143 aa)
	PCGF5	Polycomb group ring finger 5. (256 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (913 aa)
	RNF168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (561 aa)
	PCGF1	Polycomb group ring finger 1. (259 aa)
	ENSCATP00000020004	Uncharacterized protein; Belongs to the SKP1 family. (198 aa)
	RING1	Ring finger protein 1. (412 aa)
	BMI1	RING-type domain-containing protein. (326 aa)
	BRCA2	BRCA2 DNA repair associated. (3419 aa)
	RNF2	Ring finger protein 2. (336 aa)
	KDM2B	Lysine demethylase 2B. (1336 aa)
	RAD51	RAD51 recombinase; Belongs to the RecA family. (309 aa)
	BCOR	BCL6 corepressor. (1755 aa)
	RYBP	RING1 and YY1 binding protein. (251 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	BCOR	ENSCATP00000040920	ENSCATP00000024723	BRCA1 associated RING domain 1.	BCL6 corepressor.	0.449
BARD1	BMI1	ENSCATP00000040920	ENSCATP00000015247	BRCA1 associated RING domain 1.	RING-type domain-containing protein.	0.407
BARD1	BRCA2	ENSCATP00000040920	ENSCATP00000015406	BRCA1 associated RING domain 1.	BRCA2 DNA repair associated.	0.979
BARD1	LOC105584067	ENSCATP00000040920	ENSCATP00000036718	BRCA1 associated RING domain 1.	RING-type domain-containing protein.	0.567
BARD1	PCGF2	ENSCATP00000040920	ENSCATP00000038722	BRCA1 associated RING domain 1.	Polycomb group ring finger 2.	0.407
BARD1	PCGF6	ENSCATP00000040920	ENSCATP00000038406	BRCA1 associated RING domain 1.	Polycomb group ring finger 6.	0.407
BARD1	RAD51	ENSCATP00000040920	ENSCATP00000019738	BRCA1 associated RING domain 1.	RAD51 recombinase; Belongs to the RecA family.	0.945
BARD1	RING1	ENSCATP00000040920	ENSCATP00000009019	BRCA1 associated RING domain 1.	Ring finger protein 1.	0.496
BARD1	RNF168	ENSCATP00000040920	ENSCATP00000026222	BRCA1 associated RING domain 1.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	0.751
BARD1	RNF2	ENSCATP00000040920	ENSCATP00000016987	BRCA1 associated RING domain 1.	Ring finger protein 2.	0.567
BCOR	BARD1	ENSCATP00000024723	ENSCATP00000040920	BCL6 corepressor.	BRCA1 associated RING domain 1.	0.449
BCOR	BMI1	ENSCATP00000024723	ENSCATP00000015247	BCL6 corepressor.	RING-type domain-containing protein.	0.426
BCOR	BRCA2	ENSCATP00000024723	ENSCATP00000015406	BCL6 corepressor.	BRCA2 DNA repair associated.	0.453
BCOR	ENSCATP00000020004	ENSCATP00000024723	ENSCATP00000020004	BCL6 corepressor.	Uncharacterized protein; Belongs to the SKP1 family.	0.697
BCOR	KDM2B	ENSCATP00000024723	ENSCATP00000017804	BCL6 corepressor.	Lysine demethylase 2B.	0.887
BCOR	LOC105584067	ENSCATP00000024723	ENSCATP00000036718	BCL6 corepressor.	RING-type domain-containing protein.	0.848
BCOR	PCGF1	ENSCATP00000024723	ENSCATP00000025158	BCL6 corepressor.	Polycomb group ring finger 1.	0.938
BCOR	PCGF2	ENSCATP00000024723	ENSCATP00000038722	BCL6 corepressor.	Polycomb group ring finger 2.	0.435
BCOR	PCGF3	ENSCATP00000024723	ENSCATP00000036883	BCL6 corepressor.	Polycomb group ring finger 3.	0.468
BCOR	PCGF5	ENSCATP00000024723	ENSCATP00000045591	BCL6 corepressor.	Polycomb group ring finger 5.	0.433