STRINGSTRING
DCLRE1B DCLRE1B FAAP20 FAAP20 XPA XPA XRCC3 XRCC3 SLX4 SLX4 NUCKS1 NUCKS1 MCM9 MCM9 ERCC6L2 ERCC6L2 FANCL FANCL ENSCATP00000014233 ENSCATP00000014233 FANCC FANCC RFWD3 RFWD3 FANCG FANCG FANCA FANCA FAAP100 FAAP100 ATR ATR ERCC4 ERCC4 NEIL3 NEIL3 RAD51 RAD51 FANCD2 FANCD2 POLN POLN FANCI FANCI FANCE FANCE FANCB FANCB HROB HROB RAD51AP2 RAD51AP2 RNF168 RNF168 DCLRE1A DCLRE1A CENPX CENPX FAAP24 FAAP24 VCP VCP ERCC1 ERCC1 FAN1 FAN1 RAD51AP1 RAD51AP1 EXO5 EXO5 FANCM FANCM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DCLRE1BDNA cross-link repair 1B. (532 aa)
FAAP20Uncharacterized protein. (184 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (381 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1813 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
ERCC6L2Uncharacterized protein. (1455 aa)
FANCLFA complementation group L. (380 aa)
ENSCATP00000014233Uncharacterized protein. (276 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
RFWD3Ring finger and WD repeat domain 3. (774 aa)
FANCGFA complementation group G. (622 aa)
FANCAFA complementation group A. (1430 aa)
FAAP100FA core complex associated protein 100. (881 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2573 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
NEIL3Nei like DNA glycosylase 3. (602 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (309 aa)
FANCD2Uncharacterized protein. (1382 aa)
POLNDNA polymerase nu. (869 aa)
FANCIFA complementation group I. (1328 aa)
FANCEFA complementation group E. (536 aa)
FANCBFA complementation group B. (858 aa)
HROBChromosome 17 open reading frame 53. (640 aa)
RAD51AP2RAD51 associated protein 2. (1159 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (561 aa)
DCLRE1ADNA cross-link repair 1A. (1040 aa)
CENPXCentromere protein X. (133 aa)
FAAP24FA core complex associated protein 24. (215 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (323 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
RAD51AP1RAD51 associated protein 1. (352 aa)
EXO5Exonuclease 5. (373 aa)
FANCMFA complementation group M. (2050 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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