STRINGSTRING
TRAF2 TRAF2 PDGFA PDGFA FZD5 FZD5 KIT KIT TNF TNF FGF2 FGF2 SYK SYK HTR2B HTR2B TENM1 TENM1 P2RX7 P2RX7 LOC105584272 LOC105584272 MAP2K7 MAP2K7 FZD4 FZD4 FLT3 FLT3 SRC SRC MST1R MST1R ADAM8 ADAM8 ENSCATP00000005496 ENSCATP00000005496 MAP3K5 MAP3K5 MIF MIF MAP4K2 MAP4K2 LRRK2 LRRK2 KITLG KITLG FZD10 FZD10 NTF3 NTF3 INSR INSR ERBB2 ERBB2 PTPRC PTPRC TNFSF11 TNFSF11 ENSCATP00000008398 ENSCATP00000008398 CD40 CD40 TGFB1 TGFB1 ROBO1 ROBO1 TAOK3 TAOK3 PDCD10 PDCD10 TRAF6 TRAF6 EDN1 EDN1 PDE5A PDE5A IL34 IL34 HRAS HRAS CSK CSK FZD8 FZD8 CD24 CD24 ENSCATP00000016044 ENSCATP00000016044 WNT5A WNT5A NTRK3 NTRK3 ERP29 ERP29 PAK1 PAK1 FGF1 FGF1 AJUBA AJUBA THBS1 THBS1 NOD2 NOD2 IL1B IL1B TDGF1 TDGF1 PTK2B PTK2B DKK1 DKK1 ADAM9 ADAM9 TNFRSF11A TNFRSF11A DAB2IP DAB2IP TPD52L1 TPD52L1 AKAP13 AKAP13 ROR2 ROR2 DUSP19 DUSP19 FLT1 FLT1 DRD4 DRD4 RPS3 RPS3 AGER AGER ARHGEF5 ARHGEF5 EZH2 EZH2 PDGFC PDGFC EPGN EPGN MAGED1 MAGED1 LOC105572493 LOC105572493 MAP3K13 MAP3K13 MAP3K4 MAP3K4 MAP3K12 MAP3K12 EPHA4 EPHA4 PSEN1 PSEN1 AXIN1 AXIN1 EGFR EGFR DVL3 DVL3 PIK3CG PIK3CG FGD2 FGD2 ERN2 ERN2 PTPN1 PTPN1 PLA2G1B PLA2G1B FGF18 FGF18 MAP2K5 MAP2K5 ERN1 ERN1 ENSCATP00000036412 ENSCATP00000036412 ELANE ELANE ENSCATP00000036866 ENSCATP00000036866 EGF EGF MEF2C MEF2C MAP3K10 MAP3K10 MAP3K11 MAP3K11 NEK10 NEK10 ENSCATP00000038390 ENSCATP00000038390 LOC105573172 LOC105573172 PIK3R5 PIK3R5 EDN3 EDN3 PDGFB PDGFB TGFA TGFA FGFR1 FGFR1 TLR4 TLR4 MAP3K7 MAP3K7 ENSCATP00000042935 ENSCATP00000042935 CCL19 CCL19 RASGRP1 RASGRP1 MAP2K6 MAP2K6 IRAK1 IRAK1 DVL2 DVL2 PDGFRB PDGFRB S100A12 S100A12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
SYKNon-specific protein-tyrosine kinase. (637 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
LOC105584272KH type-2 domain-containing protein. (164 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (517 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
FLT3Fms related tyrosine kinase 3. (741 aa)
SRCTyrosine-protein kinase. (644 aa)
MST1RMacrophage stimulating 1 receptor. (1426 aa)
ADAM8ADAM metallopeptidase domain 8. (939 aa)
ENSCATP00000005496Uncharacterized protein. (107 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (825 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (278 aa)
INSRTyrosine-protein kinase receptor. (1339 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (270 aa)
ENSCATP00000008398CFC domain-containing protein. (170 aa)
CD40CD40 molecule. (278 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
TAOK3TAO kinase 3. (886 aa)
PDCD10Programmed cell death 10. (212 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
EDN1Endothelin 1. (211 aa)
PDE5APhosphodiesterase. (875 aa)
IL34Interleukin 34. (242 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CSKTyrosine-protein kinase. (450 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (600 aa)
CD24CD24 molecule. (126 aa)
ENSCATP00000016044Protein kinase domain-containing protein. (357 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (382 aa)
NTRK3Tyrosine-protein kinase receptor. (866 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
AJUBAAjuba LIM protein. (538 aa)
THBS1Thrombospondin 1. (1170 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (182 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
ADAM9ADAM metallopeptidase domain 9. (743 aa)
TNFRSF11ATNF receptor superfamily member 11a. (616 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
TPD52L1TPD52 like 1. (221 aa)
AKAP13A-kinase anchoring protein 13. (2816 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (217 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (415 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (268 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1597 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
EPGNEpithelial mitogen. (154 aa)
MAGED1MAGE family member D1. (690 aa)
LOC105572493KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (242 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1771 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (890 aa)
EPHA4EPH receptor A4. (986 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
AXIN1Axin 1. (867 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (655 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (926 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
PLA2G1BPhospholipase A(2). (148 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (472 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
ENSCATP00000036412Uncharacterized protein. (144 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (263 aa)
ENSCATP00000036866Uncharacterized protein. (55 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (952 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
NEK10NIMA related kinase 10. (1173 aa)
ENSCATP00000038390Uncharacterized protein. (144 aa)
LOC105573172Uncharacterized protein. (906 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (880 aa)
EDN3Endothelin 3. (230 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
TGFATransforming growth factor alpha. (166 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (586 aa)
ENSCATP00000042935Ribosomal_S3_C domain-containing protein. (236 aa)
CCL19C-C motif chemokine. (123 aa)
RASGRP1RAS guanyl releasing protein 1. (837 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (721 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (90 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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