52 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UBE2F	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (185 aa)
	PADI4	Peptidyl arginine deiminase 4. (663 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	JAK2	Tyrosine-protein kinase. (1137 aa)
	SENP8	SUMO peptidase family member, NEDD8 specific. (212 aa)
	FN3K	Fructosamine 3 kinase; Belongs to the fructosamine kinase family. (309 aa)
	AGBL4	ATP/GTP binding protein like 4. (291 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1512 aa)
	COPS5	COP9 signalosome subunit 5. (334 aa)
	UBE2M	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	DSCC1	DNA replication and sister chromatid cohesion 1. (374 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	FOLH1	Folate hydrolase 1. (750 aa)
	ESCO1	Establishment of sister chromatid cohesion N-acetyltransferase 1. (802 aa)
	UCHL3	Ubiquitin carboxyl-terminal hydrolase. (281 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	PKN1	Protein kinase N1. (949 aa)
	LOC105596945	Uncharacterized protein. (418 aa)
	RPS6KA4	Ribosomal protein S6 kinase. (763 aa)
	WIPI2	WD repeat domain, phosphoinositide interacting 2. (456 aa)
	ESCO2	Establishment of sister chromatid cohesion N-acetyltransferase 2. (582 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ICMT	Protein-S-isoprenylcysteine O-methyltransferase. (284 aa)
	ENSCATP00000020111	UBIQUITIN_CONJUGAT_2 domain-containing protein. (148 aa)
	STT3B	STT3 oligosaccharyltransferase complex catalytic subunit B. (825 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (703 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	AGBL5	ATP/GTP binding protein like 5. (886 aa)
	ENSCATP00000023705	RING-type domain-containing protein. (100 aa)
	RBX1	Ring-box 1. (108 aa)
	AGBL1	ATP/GTP binding protein like 1. (1053 aa)
	ENSCATP00000027471	Uncharacterized protein. (54 aa)
	TTL	Tubulin tyrosine ligase. (377 aa)
	FN3KRP	Fructosamine 3 kinase related protein; Belongs to the fructosamine kinase family. (309 aa)
	FAM20C	FAM20C golgi associated secretory pathway kinase. (584 aa)
	LCMT1	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (334 aa)
	LOC105571669	Pepdidase_M14_N domain-containing protein. (217 aa)
	MAP3K12	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (890 aa)
	RPS6KA5	Non-specific serine/threonine protein kinase. (896 aa)
	ATG16L1	Autophagy related 16 like 1. (624 aa)
	SIRT6	Sirtuin 6. (355 aa)
	BAZ1B	Bromodomain adjacent to zinc finger domain 1B. (1469 aa)
	ENSCATP00000035546	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (178 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (847 aa)
	SUMF1	Sulfatase modifying factor 1. (374 aa)
	IRGM	Immunity related GTPase M. (159 aa)
	RNF7	Ring finger protein 7. (113 aa)
	RHBDD1	Rhomboid domain containing 1. (316 aa)
	HLCS	Holocarboxylase synthetase. (874 aa)
	VIPAS39	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (519 aa)
	AURKB	Aurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
	AGTPBP1	ATP/GTP binding protein 1. (1210 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGBL4	LOC105571669	ENSCATP00000004291	ENSCATP00000029462	ATP/GTP binding protein like 4.	Pepdidase_M14_N domain-containing protein.	0.548
ATG16L1	ATG5	ENSCATP00000031110	ENSCATP00000018165	Autophagy related 16 like 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.998
ATG16L1	ATG7	ENSCATP00000031110	ENSCATP00000022229	Autophagy related 16 like 1.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.833
ATG16L1	IRGM	ENSCATP00000031110	ENSCATP00000037954	Autophagy related 16 like 1.	Immunity related GTPase M.	0.541
ATG16L1	LOC105596945	ENSCATP00000031110	ENSCATP00000015458	Autophagy related 16 like 1.	Uncharacterized protein.	0.963
ATG16L1	WIPI2	ENSCATP00000031110	ENSCATP00000016750	Autophagy related 16 like 1.	WD repeat domain, phosphoinositide interacting 2.	0.963
ATG5	ATG16L1	ENSCATP00000018165	ENSCATP00000031110	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy related 16 like 1.	0.998
ATG5	ATG7	ENSCATP00000018165	ENSCATP00000022229	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.978
ATG5	IRGM	ENSCATP00000018165	ENSCATP00000037954	Autophagy protein 5; Involved in autophagic vesicle formation.	Immunity related GTPase M.	0.668
ATG5	LOC105596945	ENSCATP00000018165	ENSCATP00000015458	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.906
ATG5	WIPI2	ENSCATP00000018165	ENSCATP00000016750	Autophagy protein 5; Involved in autophagic vesicle formation.	WD repeat domain, phosphoinositide interacting 2.	0.938
ATG7	ATG16L1	ENSCATP00000022229	ENSCATP00000031110	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Autophagy related 16 like 1.	0.833
ATG7	ATG5	ENSCATP00000022229	ENSCATP00000018165	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Autophagy protein 5; Involved in autophagic vesicle formation.	0.978
ATG7	ENSCATP00000020111	ENSCATP00000022229	ENSCATP00000020111	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.688
ATG7	ENSCATP00000035546	ENSCATP00000022229	ENSCATP00000035546	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.688
ATG7	LOC105596945	ENSCATP00000022229	ENSCATP00000015458	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Uncharacterized protein.	0.736
ATG7	RBX1	ENSCATP00000022229	ENSCATP00000025654	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ring-box 1.	0.439
ATG7	SENP8	ENSCATP00000022229	ENSCATP00000005576	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	SUMO peptidase family member, NEDD8 specific.	0.473
ATG7	UBE2F	ENSCATP00000022229	ENSCATP00000009450	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.688
ATG7	UBE2M	ENSCATP00000022229	ENSCATP00000010309	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.698