94 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3073 aa)
	M1AP	Meiosis 1 associated protein. (530 aa)
	HORMAD1	HORMA domain containing 1. (394 aa)
	PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha. (589 aa)
	RAD51C	RAD51 paralog C. (367 aa)
	SYCE1L	Synaptonemal complex central element protein 1 like. (242 aa)
	ESPL1	Extra spindle pole bodies like 1, separase. (2120 aa)
	PTTG2	Pituitary tumor-transforming 2. (174 aa)
	ZCWPW1	Zinc finger CW-type and PWWP domain containing 1. (632 aa)
	MLH1	MutL homolog 1. (756 aa)
	TEX12	Testis expressed 12. (123 aa)
	NCAPH	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (740 aa)
	TEX11	Testis expressed 11. (925 aa)
	SYCE2	Synaptonemal complex central element protein 2. (218 aa)
	C14orf39	Chromosome 14 open reading frame 39. (588 aa)
	BRIP1	BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (396 aa)
	SIRT7	Sirtuin 7. (400 aa)
	MND1	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (205 aa)
	ENSCATP00000038940	Uncharacterized protein. (566 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (955 aa)
	PLK1	Serine/threonine-protein kinase PLK. (603 aa)
	CCNB1IP1	Cyclin B1 interacting protein 1. (277 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
	ACTR3B	Actin related protein 3B; Belongs to the actin family. (418 aa)
	PSMC3IP	PSMC3 interacting protein. (217 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1266 aa)
	SLX4	SLX4 structure-specific endonuclease subunit. (1813 aa)
	NDC1	NDC1 transmembrane nucleoporin. (674 aa)
	MEI4	Meiotic double-stranded break formation protein 4. (384 aa)
	RNF212	Uncharacterized protein. (273 aa)
	FMN2	Formin 2. (1435 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (404 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (1096 aa)
	PTTG1	PTTG1 regulator of sister chromatid separation, securin. (202 aa)
	MAJIN	Uncharacterized protein. (176 aa)
	ENSCATP00000001512	Uncharacterized protein. (182 aa)
	SYCP2	Synaptonemal complex protein 2. (1530 aa)
	C1orf146	Chromosome 1 open reading frame 146. (180 aa)
	NUF2	NUF2 component of NDC80 kinetochore complex. (450 aa)
	HORMAD2	HORMA domain containing 2. (307 aa)
	SUN1	Sad1 and UNC84 domain containing 1. (932 aa)
	SHOC1	Shortage in chiasmata 1. (1444 aa)
	TEX15	Testis expressed 15, meiosis and synapsis associated. (3181 aa)
	MEIOB	Meiosis specific with OB-fold. (471 aa)
	SPATA22	Spermatogenesis associated 22. (363 aa)
	SMC4	Structural maintenance of chromosomes protein. (1287 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
	SGO2	Shugoshin 2. (1260 aa)
	BUB1B	BUB1 N-terminal domain-containing protein. (1073 aa)
	ANKRD31	Ankyrin repeat domain 31. (1875 aa)
	STAG2	Stromal antigen 2. (1268 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa)
	TOP2B	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1626 aa)
	CCDC36	Coiled-coil domain containing 36. (599 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1530 aa)
	HFM1	Helicase for meiosis 1. (1435 aa)
	ENSCATP00000014233	Uncharacterized protein. (276 aa)
	FANCM	FA complementation group M. (2050 aa)
	CCDC155	Coiled-coil domain containing 155. (562 aa)
	SGO1	Shugoshin 1. (527 aa)
	SMC2	Structural maintenance of chromosomes protein. (1197 aa)
	P3H4	Prolyl 3-hydroxylase family member 4 (non-enzymatic). (437 aa)
	ENSCATP00000019755	Rad21_Rec8 domain-containing protein. (141 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
	SYCE1	Synaptonemal complex central element protein 1. (328 aa)
	CENPC	Centromere protein C. (945 aa)
	ACTR3	Actin related protein 3; Belongs to the actin family. (418 aa)
	EME2	Essential meiotic structure-specific endonuclease subunit 2. (379 aa)
	TERB2	Telomere repeat binding bouquet formation protein 2. (221 aa)
	MSH5	DNA_MISMATCH_REPAIR_2 domain-containing protein. (834 aa)
	NCAPH2	Non-SMC condensin II complex subunit H2. (611 aa)
	RAD21	RAD21 cohesin complex component. (631 aa)
	ANKLE1	Ankyrin repeat and LEM domain containing 1. (664 aa)
	TERB1	Telomere repeat binding bouquet formation protein 1. (739 aa)
	MSH4	MutS homolog 4. (935 aa)
	STAG3	Stromal antigen 3. (1268 aa)
	BAG6	BCL2 associated athanogene 6. (1126 aa)
	STAG1	Stromal antigen 1. (1291 aa)
	MAEL	Maelstrom spermatogenic transposon silencer. (434 aa)
	CENPS-CORT	CENPS-CORT readthrough. (143 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (410 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (319 aa)
	SEPTIN1	Septin 1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (403 aa)
	CENPX	Centromere protein X. (133 aa)
	MEIKIN	Meiotic kinetochore factor. (374 aa)
	MLH3	MutL homolog 3. (1436 aa)
	REC8	REC8 meiotic recombination protein. (549 aa)
	SYCE3	Synaptonemal complex central element protein 3. (88 aa)
	MUS81	MUS81 structure-specific endonuclease subunit. (559 aa)
	SMC1A	Structural maintenance of chromosomes protein. (1233 aa)
	FANCD2	Uncharacterized protein. (1382 aa)
	SYCP1	Synaptonemal complex protein 1. (976 aa)
	LOC105593797	Uncharacterized protein. (775 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTR3	ACTR3B	ENSCATP00000021272	ENSCATP00000042651	Actin related protein 3; Belongs to the actin family.	Actin related protein 3B; Belongs to the actin family.	0.958
ACTR3	CCNE1	ENSCATP00000021272	ENSCATP00000026673	Actin related protein 3; Belongs to the actin family.	Cyclin E1; Belongs to the cyclin family.	0.467
ACTR3	CCNE2	ENSCATP00000021272	ENSCATP00000045370	Actin related protein 3; Belongs to the actin family.	Cyclin E2; Belongs to the cyclin family.	0.467
ACTR3B	ACTR3	ENSCATP00000042651	ENSCATP00000021272	Actin related protein 3B; Belongs to the actin family.	Actin related protein 3; Belongs to the actin family.	0.958
ACTR3B	CCNE1	ENSCATP00000042651	ENSCATP00000026673	Actin related protein 3B; Belongs to the actin family.	Cyclin E1; Belongs to the cyclin family.	0.467
ACTR3B	CCNE2	ENSCATP00000042651	ENSCATP00000045370	Actin related protein 3B; Belongs to the actin family.	Cyclin E2; Belongs to the cyclin family.	0.467
ANKRD31	CCDC36	ENSCATP00000009940	ENSCATP00000011766	Ankyrin repeat domain 31.	Coiled-coil domain containing 36.	0.481
ANKRD31	LOC105593797	ENSCATP00000009940	ENSCATP00000032632	Ankyrin repeat domain 31.	Uncharacterized protein.	0.416
ANKRD31	SYCE1	ENSCATP00000009940	ENSCATP00000020653	Ankyrin repeat domain 31.	Synaptonemal complex central element protein 1.	0.424
ANKRD31	SYCP1	ENSCATP00000009940	ENSCATP00000032556	Ankyrin repeat domain 31.	Synaptonemal complex protein 1.	0.436
ATM	BRIP1	ENSCATP00000032722	ENSCATP00000038053	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA1 interacting protein C-terminal helicase 1.	0.742
ATM	DMC1	ENSCATP00000032722	ENSCATP00000027243	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.706
ATM	EME2	ENSCATP00000032722	ENSCATP00000022179	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Essential meiotic structure-specific endonuclease subunit 2.	0.428
ATM	ENSCATP00000014233	ENSCATP00000032722	ENSCATP00000014233	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.524
ATM	ERCC4	ENSCATP00000032722	ENSCATP00000020198	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ERCC excision repair 4, endonuclease catalytic subunit.	0.750
ATM	FANCD2	ENSCATP00000032722	ENSCATP00000030850	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.524
ATM	FANCM	ENSCATP00000032722	ENSCATP00000014720	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	FA complementation group M.	0.679
ATM	MEIOB	ENSCATP00000032722	ENSCATP00000003686	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiosis specific with OB-fold.	0.711
ATM	MLH1	ENSCATP00000032722	ENSCATP00000036230	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutL homolog 1.	0.855
ATM	MLH3	ENSCATP00000032722	ENSCATP00000029297	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutL homolog 3.	0.744