STRINGSTRING
CTLA4 CTLA4 SMARCC1 SMARCC1 PRKCZ PRKCZ IRF1 IRF1 TOX TOX RC3H2 RC3H2 GLI3 GLI3 VNN3 VNN3 SLC46A2 SLC46A2 AMBRA1 AMBRA1 TNFSF4 TNFSF4 PRELID1 PRELID1 SHB SHB SMAD7 SMAD7 ARID1B ARID1B ZC3H12A ZC3H12A ADA ADA XBP1 XBP1 BCL6 BCL6 ENSCATP00000029280 ENSCATP00000029280 AP3B1 AP3B1 IL4R IL4R DUSP10 DUSP10 ZAP70 ZAP70 KAT5 KAT5 ENSCATP00000030673 ENSCATP00000030673 FANCD2 FANCD2 SHH SHH ZBTB16 ZBTB16 NCKAP1L NCKAP1L IL36B IL36B FOXN1 FOXN1 TGFBR2 TGFBR2 ARID2 ARID2 MALT1 MALT1 ZMIZ1 ZMIZ1 RUNX1 RUNX1 ENSCATP00000036371 ENSCATP00000036371 CLPTM1 CLPTM1 ACTL6B ACTL6B CD74 CD74 PHF10 PHF10 NFKBID NFKBID VSIR VSIR CLEC4G CLEC4G IL15 IL15 MDK MDK SOS2 SOS2 BMP4 BMP4 WNT10B WNT10B CBFB CBFB LAG3 LAG3 RIPK2 RIPK2 IL4 IL4 SMARCD2 SMARCD2 CD28 CD28 IL23R IL23R BTN2A2 BTN2A2 KAT2A KAT2A IFNB1 IFNB1 ENSCATP00000006016 ENSCATP00000006016 SOCS5 SOCS5 RAG2 RAG2 RHOA RHOA ZEB1 ZEB1 RUNX3 RUNX3 ENSCATP00000014348 ENSCATP00000014348 TMEM131L TMEM131L ADAM8 ADAM8 IRF4 IRF4 SOS1 SOS1 ENSCATP00000003834 ENSCATP00000003834 NRARP NRARP SOX4 SOX4 TESPA1 TESPA1 SMARCD1 SMARCD1 IHH IHH FOXP3 FOXP3 NFKBIZ NFKBIZ TBX21 TBX21 STAT5B STAT5B SOCS1 SOCS1 SYK SYK TNFSF18 TNFSF18 LOXL3 LOXL3 ENSCATP00000014233 ENSCATP00000014233 IFNL1 IFNL1 EGR3 EGR3 HLX HLX MYB MYB SMARCA4 SMARCA4 ZBTB7B ZBTB7B IL23A IL23A SMARCB1 SMARCB1 PRDM1 PRDM1 PTPN2 PTPN2 NLRP3 NLRP3 FANCA FANCA SPINK5 SPINK5 TGFB1 TGFB1 ENSCATP00000009181 ENSCATP00000009181 PTPRC PTPRC PBRM1 PBRM1 ERBB2 ERBB2 JAK3 JAK3 SMARCD3 SMARCD3 ZC3H8 ZC3H8 CARD11 CARD11 ITPKB ITPKB IL2RG IL2RG SMARCA2 SMARCA2 BATF BATF TNFSF9 TNFSF9 ZBTB1 ZBTB1 ABL1 ABL1 CD83 CD83 ANXA1 ANXA1 SMARCC2 SMARCC2 FGL2 FGL2 CD80 CD80 SART1 SART1 PNP PNP RAG1 RAG1 BAD BAD IL12RB1 IL12RB1 SASH3 SASH3 VNN1 VNN1 SMARCE1 SMARCE1 ENSCATP00000019028 ENSCATP00000019028 AP3D1 AP3D1 RC3H1 RC3H1 CD86 CD86 ENSCATP00000019834 ENSCATP00000019834 CAMK4 CAMK4 BRAF BRAF CYP26B1 CYP26B1 GLI2 GLI2 IL2 IL2 METTL3 METTL3 IFNG IFNG LEF1 LEF1 CD27 CD27 SOX12 SOX12 IL18 IL18 CCL19 CCL19 RASGRP1 RASGRP1 TCF7 TCF7 IL1RL2 IL1RL2 IL4I1 IL4I1 SH3RF1 SH3RF1 SOX13 SOX13 RARA RARA ZNF683 ZNF683 FOXJ1 FOXJ1 CCR2 CCR2 JUNB JUNB PCK1 PCK1 RHOH RHOH IL27 IL27 DROSHA DROSHA IL7 IL7 ARID1A ARID1A IL7R IL7R HLA-DOA HLA-DOA CRTAM CRTAM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTLA4CD152 protein. (223 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1105 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
IRF1Interferon regulatory factor. (325 aa)
TOXThymocyte selection associated high mobility group box. (526 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
GLI3GLI family zinc finger 3. (1580 aa)
VNN3Vanin 3. (274 aa)
SLC46A2Solute carrier family 46 member 2. (475 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
PRELID1PRELI domain containing 1. (219 aa)
SHBSH2 domain containing adaptor protein B. (509 aa)
SMAD7Mothers against decapentaplegic homolog. (483 aa)
ARID1BAT-rich interaction domain 1B. (2293 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
ADAA_deaminase domain-containing protein. (449 aa)
XBP1BZIP domain-containing protein. (380 aa)
BCL6BCL6 transcription repressor. (706 aa)
ENSCATP00000029280Uncharacterized protein. (331 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
IL4RInterleukin 4 receptor. (825 aa)
DUSP10Dual specificity phosphatase 10. (505 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (537 aa)
ENSCATP00000030673Uncharacterized protein. (652 aa)
FANCD2Uncharacterized protein. (1382 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
NCKAP1LNCK associated protein 1 like. (1060 aa)
IL36BInterleukin 36 beta. (164 aa)
FOXN1Forkhead box N1. (648 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ARID2AT-rich interaction domain 2. (1836 aa)
MALT1MALT1 paracaspase. (824 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1073 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
ENSCATP00000036371A_deaminase domain-containing protein. (346 aa)
CLPTM1CLPTM1 regulator of GABA type A receptor forward trafficking. (669 aa)
ACTL6BActin like 6B; Belongs to the actin family. (426 aa)
CD74CD74 molecule. (294 aa)
PHF10PHD finger protein 10. (410 aa)
NFKBIDNFKB inhibitor delta. (505 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
MDKMidkine. (143 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CBFBCore-binding factor subunit beta. (182 aa)
LAG3Lymphocyte activating 3. (527 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (531 aa)
CD28CD28 molecule. (234 aa)
IL23RInterleukin 23 receptor. (614 aa)
BTN2A2Uncharacterized protein. (519 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
IFNB1Interferon beta 1. (187 aa)
ENSCATP00000006016Uncharacterized protein. (661 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
RAG2Recombination activating 2. (532 aa)
RHOARas homolog family member A. (193 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
ENSCATP00000014348PRELI/MSF1 domain-containing protein. (194 aa)
TMEM131LTransmembrane 131 like. (1610 aa)
ADAM8ADAM metallopeptidase domain 8. (939 aa)
IRF4Interferon regulatory factor 4. (451 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ENSCATP00000003834PTN_MK_N domain-containing protein. (60 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
SOX4Transcription factor SOX. (475 aa)
TESPA1Thymocyte expressed, positive selection associated 1. (520 aa)
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
FOXP3Forkhead box P3. (456 aa)
NFKBIZNFKB inhibitor zeta. (719 aa)
TBX21T-box transcription factor 21. (535 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
SYKNon-specific protein-tyrosine kinase. (637 aa)
TNFSF18TNF superfamily member 18. (177 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
ENSCATP00000014233Uncharacterized protein. (276 aa)
IFNL1Interferon lambda 1. (202 aa)
EGR3Early growth response 3. (387 aa)
HLXH2.0 like homeobox. (494 aa)
MYBMYB proto-oncogene, transcription factor. (761 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
PRDM1PR/SET domain 1. (825 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
FANCAFA complementation group A. (1430 aa)
SPINK5Serine peptidase inhibitor, Kazal type 5. (1087 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ENSCATP00000009181HMG box domain-containing protein. (177 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
PBRM1Polybromo 1. (1725 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (575 aa)
ZC3H8Zinc finger CCCH-type containing 8. (298 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (945 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1576 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
TNFSF9TNF superfamily member 9; Belongs to the tumor necrosis factor family. (251 aa)
ZBTB1Zinc finger and BTB domain containing 1. (644 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
CD83CD83 molecule. (205 aa)
ANXA1Annexin. (352 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1271 aa)
FGL2Fibrinogen like 2. (439 aa)
CD80CD80 molecule. (288 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (800 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1065 aa)
BADBCL2 associated agonist of cell death. (167 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (629 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
VNN1Vanin 1. (465 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
ENSCATP00000019028PRELI/MSF1 domain-containing protein. (110 aa)
AP3D1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1213 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
CD86CD86 molecule. (329 aa)
ENSCATP00000019834Uncharacterized protein. (300 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
GLI2GLI family zinc finger 2. (1586 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
CD27CD27 molecule. (260 aa)
SOX12Transcription factor SOX. (314 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CCL19C-C motif chemokine. (123 aa)
RASGRP1RAS guanyl releasing protein 1. (837 aa)
TCF7Transcription factor 7. (481 aa)
IL1RL2Interleukin 1 receptor like 2. (575 aa)
IL4I1Amine oxidase. (589 aa)
SH3RF1SH3 domain containing ring finger 1. (888 aa)
SOX13SRY-box transcription factor 13. (621 aa)
RARARetinoic acid receptor alpha. (478 aa)
ZNF683Zinc finger protein 683. (524 aa)
FOXJ1Forkhead box J1. (421 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
RHOHRas homolog family member H. (191 aa)
IL27Interleukin 27. (247 aa)
DROSHADrosha ribonuclease III. (1378 aa)
IL7Interleukin 7. (184 aa)
ARID1AAT-rich interaction domain 1A. (2286 aa)
IL7RInterleukin 7 receptor. (459 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (298 aa)
CRTAMCytotoxic and regulatory T cell molecule. (393 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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