STRINGSTRING
SCT SCT STAR STAR DGAT2 DGAT2 KIT KIT APOA5 APOA5 PRKD1 PRKD1 ABHD5 ABHD5 HTR2B HTR2B VAV3 VAV3 CREBL2 CREBL2 ANGPTL3 ANGPTL3 AGAP2 AGAP2 AADAC AADAC ACSL3 ACSL3 FLT3 FLT3 CES1 CES1 SRC SRC CNEP1R1 CNEP1R1 CPT1A CPT1A ADM ADM ABCG1 ABCG1 PTK2 PTK2 LOC105588523 LOC105588523 MID1IP1 MID1IP1 AKT1 AKT1 RPTOR RPTOR RDH10 RDH10 PPARG PPARG HSD17B13 HSD17B13 DAB2 DAB2 SCARB1 SCARB1 IGF1R IGF1R LOC105587411 LOC105587411 TGFB1 TGFB1 WNT4 WNT4 NR4A3 NR4A3 APOE APOE LDLRAP1 LDLRAP1 LPGAT1 LPGAT1 IRS1 IRS1 PNPLA2 PNPLA2 LYN LYN MLST8 MLST8 MLXIPL MLXIPL CCDC3 CCDC3 STARD4 STARD4 MTLN MTLN ATG14 ATG14 NR1H3 NR1H3 ENSCATP00000016044 ENSCATP00000016044 MFSD2A MFSD2A FGF1 FGF1 ENSCATP00000016881 ENSCATP00000016881 EPHA8 EPHA8 PPARGC1A PPARGC1A NOD2 NOD2 IL1B IL1B PTK2B PTK2B DAGLB DAGLB NR1H2 NR1H2 APOC2 APOC2 CCN1 CCN1 SLC27A1 SLC27A1 PDGFRB PDGFRB ENSCATP00000044345 ENSCATP00000044345 PLA2G3 PLA2G3 FGR FGR GHSR GHSR CCL19 CCL19 ENSCATP00000042714 ENSCATP00000042714 TNFAIP8L3 TNFAIP8L3 SCAP SCAP CTDNEP1 CTDNEP1 MLYCD MLYCD FABP3 FABP3 ABHD6 ABHD6 ERBB4 ERBB4 ZBTB20 ZBTB20 SIRT3 SIRT3 PDGFB PDGFB AVPR1A AVPR1A CCL21 CCL21 SLC45A3 SLC45A3 LDLR LDLR ABCD1 ABCD1 NR1H4 NR1H4 ADIPOQ ADIPOQ CGA CGA CD74 CD74 ABCG4 ABCG4 SREBF1 SREBF1 CCR7 CCR7 NR1D1 NR1D1 PRKCE PRKCE GPLD1 GPLD1 MTOR MTOR POR POR SPHK2 SPHK2 FGF21 FGF21 BMP6 BMP6 APOA2 APOA2 CD81 CD81 ENPP7 ENPP7 PLIN5 PLIN5 AKT2 AKT2 AVP AVP STOML2 STOML2 KAT5 KAT5 PIK3R4 PIK3R4 ABCD2 ABCD2 F2 F2 XBP1 XBP1 IRS2 IRS2 PPARA PPARA SORBS1 SORBS1 AMBRA1 AMBRA1 DGKZ DGKZ HTR2A HTR2A CREB1 CREB1 SREBF2 SREBF2 SCP2 SCP2 VAV2 VAV2 ADGRF5 ADGRF5 CYP7A1 CYP7A1 PPARD PPARD DISP3 DISP3 FABP1 FABP1 PRKCD PRKCD PLA2G6 PLA2G6 IFNG IFNG RAB38 RAB38 FLT1 FLT1 CD19 CD19 PTGS2 PTGS2 SIRT4 SIRT4 FGFR3 FGFR3 TEK TEK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCTSecretin. (125 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
APOA5Apolipoprotein A5. (366 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
ABHD5Abhydrolase domain containing 5. (349 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
CREBL2cAMP responsive element binding protein like 2. (193 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa)
AADACArylacetamide deacetylase. (399 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
FLT3Fms related tyrosine kinase 3. (741 aa)
CES1Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (567 aa)
SRCTyrosine-protein kinase. (644 aa)
CNEP1R1CTD nuclear envelope phosphatase 1 regulatory subunit 1. (142 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
ADMAdrenomedullin. (200 aa)
ABCG1ATP binding cassette subfamily G member 1. (706 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1068 aa)
LOC105588523COesterase domain-containing protein. (545 aa)
MID1IP1MID1 interacting protein 1. (183 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1314 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
HSD17B13Hydroxysteroid 17-beta dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (300 aa)
DAB2DAB adaptor protein 2. (770 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
LOC105587411COesterase domain-containing protein. (295 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
APOEApolipoprotein E. (317 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (337 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
PNPLA2Patatin like phospholipase domain containing 2. (499 aa)
LYNTyrosine-protein kinase. (507 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
MLXIPLMLX interacting protein like. (880 aa)
CCDC3Coiled-coil domain containing 3. (270 aa)
STARD4StAR related lipid transfer domain containing 4. (205 aa)
MTLNMitoregulin. (111 aa)
ATG14Autophagy related 14. (510 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (466 aa)
ENSCATP00000016044Protein kinase domain-containing protein. (357 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (530 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ENSCATP00000016881START domain-containing protein. (247 aa)
EPHA8EPH receptor A8. (1000 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
DAGLBDiacylglycerol lipase beta. (711 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
APOC2Apolipoprotein C2. (101 aa)
CCN1Cellular communication network factor 1. (381 aa)
SLC27A1Solute carrier family 27 member 1. (646 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ENSCATP00000044345FCP1 homology domain-containing protein. (206 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
FGRTyrosine-protein kinase. (496 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CCL19C-C motif chemokine. (123 aa)
ENSCATP00000042714Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (141 aa)
TNFAIP8L3TNF alpha induced protein 8 like 3. (292 aa)
SCAPSREBF chaperone. (1261 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
MLYCDMalonyl-CoA decarboxylase. (493 aa)
FABP3Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
ABHD6Abhydrolase domain containing 6. (337 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
SLC45A3Solute carrier family 45 member 3. (553 aa)
LDLRLow density lipoprotein receptor. (764 aa)
ABCD1ATP binding cassette subfamily D member 1. (740 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (482 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (150 aa)
CD74CD74 molecule. (294 aa)
ABCG4ATP binding cassette subfamily G member 4. (646 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (847 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa)
SPHK2Sphingosine kinase 2. (653 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
BMP6Bone morphogenetic protein 6. (520 aa)
APOA2Apolipoprotein A2. (132 aa)
CD81Tetraspanin. (269 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (458 aa)
PLIN5Perilipin; Belongs to the perilipin family. (462 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AVPArginine vasopressin. (164 aa)
STOML2Stomatin like 2. (361 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (537 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
ABCD2ATP binding cassette subfamily D member 2. (740 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
XBP1BZIP domain-containing protein. (380 aa)
IRS2Insulin receptor substrate 2. (1338 aa)
PPARAPeroxisome proliferator activated receptor alpha. (511 aa)
SORBS1Sorbin and SH3 domain containing 1. (1295 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
DGKZDiacylglycerol kinase. (1118 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1146 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (540 aa)
VAV2Vav guanine nucleotide exchange factor 2. (868 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1383 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
DISP3Dispatched RND transporter family member 3. (1355 aa)
FABP1Fatty acid binding protein 1. (122 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PLA2G6Phospholipase A2 group VI. (784 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
RAB38RAB38, member RAS oncogene family. (211 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
CD19CD19 molecule. (531 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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