STRINGSTRING
PRKCA PRKCA BRD4 BRD4 KLHL18 KLHL18 LSM10 LSM10 USP2 USP2 NKX3-1 NKX3-1 EIF4G1 EIF4G1 ENSCATP00000002218 ENSCATP00000002218 KCNA5 KCNA5 STAT5B STAT5B DDX3X DDX3X ENSCATP00000003394 ENSCATP00000003394 TAL1 TAL1 ADAMTS1 ADAMTS1 CPSF3 CPSF3 MECP2 MECP2 CDK4 CDK4 RB1 RB1 PRAP1 PRAP1 ENSCATP00000005869 ENSCATP00000005869 ENSCATP00000006421 ENSCATP00000006421 AKT1 AKT1 DDR2 DDR2 RPTOR RPTOR ANAPC11 ANAPC11 NEUROG1 NEUROG1 RRM2B RRM2B MEPCE MEPCE TGFB1 TGFB1 TMOD3 TMOD3 RPS6KB1 RPS6KB1 CDC23 CDC23 ENSCATP00000010330 ENSCATP00000010330 CDK10 CDK10 CENPJ CENPJ ENSCATP00000012945 ENSCATP00000012945 CDC6 CDC6 CDC25C CDC25C CUL4A CUL4A ANKRD17 ANKRD17 RRM2 RRM2 PBX1 PBX1 BRCA2 BRCA2 RAD51B RAD51B ANAPC7 ANAPC7 SASS6 SASS6 BIRC5 BIRC5 CDC7 CDC7 ABL1 ABL1 ANXA1 ANXA1 CDC25A CDC25A MTA3 MTA3 PKN2 PKN2 KMT2E KMT2E PTPN11 PTPN11 PHOX2B PHOX2B CDC25B CDC25B ENSCATP00000020360 ENSCATP00000020360 SIN3A SIN3A STIL STIL RCC2 RCC2 MEIS2 MEIS2 RRM1 RRM1 POLDIP2 POLDIP2 HSF1 HSF1 STOX1 STOX1 CCDC57 CCDC57 CCND2 CCND2 TERT TERT DBF4B DBF4B EIF4E EIF4E MAD1L1 MAD1L1 SHB SHB ADAM17 ADAM17 TTL TTL HSPA2 HSPA2 SMOC2 SMOC2 CDK1 CDK1 FGF10 FGF10 HYAL1 HYAL1 CUL3 CUL3 PPP1R10 PPP1R10 FOXA1 FOXA1 EGFR EGFR SPHK1 SPHK1 DLGAP5 DLGAP5 CDC27 CDC27 RAD51C RAD51C DTL DTL NSMCE2 NSMCE2 CCND1 CCND1 ESPL1 ESPL1 UBE2E2 UBE2E2 MTBP MTBP CCND3 CCND3 MAD2L1BP MAD2L1BP TFDP1 TFDP1 APP APP LSM11 LSM11 WNT10B WNT10B CCNB1 CCNB1 ENSCATP00000040503 ENSCATP00000040503 LGMN LGMN AIF1 AIF1 CDC16 CDC16 CDT1 CDT1 PLRG1 PLRG1 EIF4EBP1 EIF4EBP1 CDCA5 CDCA5 ENSCATP00000044421 ENSCATP00000044421 ENSCATP00000044566 ENSCATP00000044566 PLCB1 PLCB1 FBXO5 FBXO5 RGCC RGCC CUL4B CUL4B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
BRD4Bromodomain containing 4. (1217 aa)
KLHL18Kelch like family member 18. (579 aa)
LSM10LSM10, U7 small nuclear RNA associated. (123 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (605 aa)
NKX3-1NK3 homeobox 1. (232 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1604 aa)
ENSCATP00000002218Uncharacterized protein. (228 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (711 aa)
ENSCATP00000003394Transcription factor. (393 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (676 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (501 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RB1RB transcriptional corepressor 1. (926 aa)
PRAP1Uncharacterized protein. (152 aa)
ENSCATP00000005869Uncharacterized protein. (526 aa)
ENSCATP00000006421Protein kinase domain-containing protein. (297 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (873 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1314 aa)
ANAPC11Anaphase promoting complex subunit 11. (180 aa)
NEUROG1Neurogenin 1. (237 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (352 aa)
MEPCEMethylphosphate capping enzyme. (690 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TMOD3Tropomodulin 3. (352 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CDC23Cell division cycle 23. (597 aa)
ENSCATP00000010330Uncharacterized protein. (393 aa)
CDK10Cyclin dependent kinase 10; Belongs to the protein kinase superfamily. (360 aa)
CENPJCentromere protein J. (1340 aa)
ENSCATP00000012945Protein kinase domain-containing protein. (101 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (599 aa)
CDC25CCell division cycle 25C. (471 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
ANKRD17Ankyrin repeat domain 17. (2603 aa)
RRM2Uncharacterized protein. (394 aa)
PBX1PBX homeobox 1. (430 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
RAD51BRAD51 paralog B. (425 aa)
ANAPC7Anaphase promoting complex subunit 7. (559 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
BIRC5Uncharacterized protein. (147 aa)
CDC7Protein kinase domain-containing protein. (574 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ANXA1Annexin. (352 aa)
CDC25ACell division cycle 25A. (524 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
PKN2Protein kinase N2. (983 aa)
KMT2ELysine methyltransferase 2E. (1860 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
CDC25BCell division cycle 25B. (580 aa)
ENSCATP00000020360SP-RING-type domain-containing protein. (201 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
STILSTIL centriolar assembly protein. (1236 aa)
RCC2Regulator of chromosome condensation 2. (522 aa)
MEIS2Meis homeobox 2. (477 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
POLDIP2DNA polymerase delta interacting protein 2. (408 aa)
HSF1Heat shock transcription factor 1. (532 aa)
STOX1Storkhead box 1. (878 aa)
CCDC57Coiled-coil domain containing 57. (898 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1123 aa)
DBF4BDBF4 zinc finger B. (436 aa)
EIF4EEukaryotic translation initiation factor 4E. (247 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (718 aa)
SHBSH2 domain containing adaptor protein B. (509 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
TTLTubulin tyrosine ligase. (377 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (602 aa)
SMOC2SPARC related modular calcium binding 2. (449 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HYAL1Hyaluronidase. (435 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (940 aa)
FOXA1Forkhead box A1. (470 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
SPHK1Sphingosine kinase 1. (470 aa)
DLGAP5DLG associated protein 5. (851 aa)
CDC27Cell division cycle 27. (830 aa)
RAD51CRAD51 paralog C. (367 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
NSMCE2SP-RING-type domain-containing protein. (246 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2120 aa)
UBE2E2Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
MTBPMDM2 binding protein. (904 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
MAD2L1BPMAD2L1 binding protein. (306 aa)
TFDP1Transcription factor. (417 aa)
APPAmyloid beta precursor protein. (770 aa)
LSM11LSM11, U7 small nuclear RNA associated. (360 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
ENSCATP00000040503FERM domain-containing protein. (476 aa)
LGMNLegumain. (433 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
CDC16Cell division cycle 16. (602 aa)
CDT1Chromatin licensing and DNA replication factor 1. (545 aa)
PLRG1Pleiotropic regulator 1. (514 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
CDCA5Cell division cycle associated 5. (307 aa)
ENSCATP00000044421Uncharacterized protein. (441 aa)
ENSCATP00000044566Protein kinase domain-containing protein. (546 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
FBXO5F-box protein 5. (448 aa)
RGCCRegulator of cell cycle. (137 aa)
CUL4BCullin 4B; Belongs to the cullin family. (913 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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