37 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCATP00000044372	Uncharacterized protein. (731 aa)
	SLIT1	Slit guidance ligand 1. (1514 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	PAX2	Paired box 2. (417 aa)
	NF1	Neurofibromin 1. (2839 aa)
	HESX1	HESX homeobox 1. (185 aa)
	ENSCATP00000034500	Uncharacterized protein. (464 aa)
	SPEF2	Sperm flagellar 2. (2179 aa)
	GSX2	GS homeobox 2. (304 aa)
	CTNNA1	Catenin alpha 1. (906 aa)
	DUOX2	Dual oxidase 2. (1546 aa)
	ZNF335	Zinc finger protein 335. (1346 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (721 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	FANCD2	Uncharacterized protein. (1382 aa)
	BBS1	BBS1 domain-containing protein. (593 aa)
	UCHL5	Ubiquitin carboxyl-terminal hydrolase. (368 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	CTNNA2	Catenin alpha 2. (953 aa)
	SLC6A4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
	BBS4	Bardet-Biedl syndrome 4. (347 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	MKKS	McKusick-Kaufman syndrome. (570 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (382 aa)
	OTX1	Orthodenticle homeobox 1. (354 aa)
	SLC4A10	Anion exchange protein. (1146 aa)
	EMX1	Empty spiracles homeobox 1. (290 aa)
	ENSCATP00000014233	Uncharacterized protein. (276 aa)
	FANCC	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	VPS51	VPS51 subunit of GARP complex. (809 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1739 aa)
	GDF7	Growth differentiation factor 7. (448 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	FBXW11	F-box and WD repeat domain containing 11. (563 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT3	PTEN	ENSCATP00000019579	ENSCATP00000013554	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.632
BBS1	BBS2	ENSCATP00000025350	ENSCATP00000031396	BBS1 domain-containing protein.	Bardet-Biedl syndrome 2 protein homolog.	0.995
BBS1	BBS4	ENSCATP00000025350	ENSCATP00000017065	BBS1 domain-containing protein.	Bardet-Biedl syndrome 4.	0.997
BBS1	SMO	ENSCATP00000025350	ENSCATP00000019640	BBS1 domain-containing protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.751
BBS2	BBS1	ENSCATP00000031396	ENSCATP00000025350	Bardet-Biedl syndrome 2 protein homolog.	BBS1 domain-containing protein.	0.995
BBS2	BBS4	ENSCATP00000031396	ENSCATP00000017065	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 4.	0.996
BBS2	MKKS	ENSCATP00000031396	ENSCATP00000016293	Bardet-Biedl syndrome 2 protein homolog.	McKusick-Kaufman syndrome.	0.402
BBS2	SMO	ENSCATP00000031396	ENSCATP00000019640	Bardet-Biedl syndrome 2 protein homolog.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.672
BBS4	BBS1	ENSCATP00000017065	ENSCATP00000025350	Bardet-Biedl syndrome 4.	BBS1 domain-containing protein.	0.997
BBS4	BBS2	ENSCATP00000017065	ENSCATP00000031396	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 2 protein homolog.	0.996
BBS4	SMO	ENSCATP00000017065	ENSCATP00000019640	Bardet-Biedl syndrome 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.658
CTNNA1	CTNNA2	ENSCATP00000033512	ENSCATP00000019555	Catenin alpha 1.	Catenin alpha 2.	0.858
CTNNA1	FANCD2	ENSCATP00000033512	ENSCATP00000030850	Catenin alpha 1.	Uncharacterized protein.	0.483
CTNNA2	CTNNA1	ENSCATP00000019555	ENSCATP00000033512	Catenin alpha 2.	Catenin alpha 1.	0.858
CTNNA2	ENSCATP00000044372	ENSCATP00000019555	ENSCATP00000044372	Catenin alpha 2.	Uncharacterized protein.	0.860
ENSCATP00000014233	FANCC	ENSCATP00000014233	ENSCATP00000013745	Uncharacterized protein.	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	0.945
ENSCATP00000044372	CTNNA2	ENSCATP00000044372	ENSCATP00000019555	Uncharacterized protein.	Catenin alpha 2.	0.860
ENSCATP00000044372	FANCD2	ENSCATP00000044372	ENSCATP00000030850	Uncharacterized protein.	Uncharacterized protein.	0.483
FANCC	ENSCATP00000014233	ENSCATP00000013745	ENSCATP00000014233	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	Uncharacterized protein.	0.945
FANCC	FANCD2	ENSCATP00000013745	ENSCATP00000030850	Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.	Uncharacterized protein.	0.984