STRINGSTRING
KDM5B KDM5B BMP2 BMP2 NKX2-6 NKX2-6 CCL26 CCL26 NR4A3 NR4A3 FGF9 FGF9 ESRP2 ESRP2 ITGA4 ITGA4 MST1 MST1 EYA1 EYA1 TGFBR1 TGFBR1 LACRT LACRT GHRL GHRL VEGFA VEGFA HLX HLX AR AR SRSF6 SRSF6 EGR3 EGR3 PRKCA PRKCA HRAS HRAS VEGFB VEGFB PPP1R16B PPP1R16B NKX2-5 NKX2-5 TGM1 TGM1 ENSCATP00000015541 ENSCATP00000015541 ID1 ID1 MED1 MED1 TCF7L2 TCF7L2 ITGB3 ITGB3 THBS4 THBS4 WNT5A WNT5A NRP2 NRP2 MYDGF MYDGF FGF1 FGF1 MMP12 MMP12 SFRP1 SFRP1 STAT3 STAT3 VIP VIP NOD2 NOD2 MTA3 MTA3 C5AR1 C5AR1 PDPK1 PDPK1 ECM1 ECM1 BAD BAD BMPR2 BMPR2 HAS2 HAS2 BMPR1A BMPR1A AKT3 AKT3 SMO SMO NME1 NME1 WNT7A WNT7A ENSCATP00000019930 ENSCATP00000019930 TEK TEK BTK BTK VEGFD VEGFD ZNF703 ZNF703 CTNNB1 CTNNB1 HPN HPN CYBA CYBA PLCG1 PLCG1 REG3G REG3G TACR1 TACR1 AREG AREG FLT4 FLT4 YAP1 YAP1 ODAM ODAM F3 F3 PDX1 PDX1 TP63 TP63 DLX6 DLX6 EPGN EPGN JCAD JCAD CLDN1 CLDN1 EMC10 EMC10 IL10 IL10 ZNF304 ZNF304 RUNX2 RUNX2 CYP7B1 CYP7B1 WDR48 WDR48 OSR2 OSR2 DLX5 DLX5 HMOX1 HMOX1 GHSR GHSR IL18 IL18 RREB1 RREB1 IGF1 IGF1 FOXE3 FOXE3 FGFR1 FGFR1 TGFA TGFA FGF7 FGF7 AGTR1 AGTR1 PDGFB PDGFB VASH2 VASH2 IGF2 IGF2 HSF4 HSF4 SCG2 SCG2 LAMC1 LAMC1 SEMA5A SEMA5A BMP4 BMP4 MDK MDK ST8SIA1 ST8SIA1 PIK3CD PIK3CD NOTCH2 NOTCH2 ARNT ARNT AGGF1 AGGF1 SPINK1 SPINK1 TNFAIP3 TNFAIP3 OSR1 OSR1 EGF EGF CCL24 CCL24 NR4A1 NR4A1 LRG1 LRG1 NRAS NRAS SIRT1 SIRT1 RTN4 RTN4 MAP2K5 MAP2K5 VEGFC VEGFC PROK1 PROK1 TBX1 TBX1 PAX2 PAX2 NF1 NF1 CCND1 CCND1 B4GALT1 B4GALT1 WNT2 WNT2 BMP6 BMP6 NRP1 NRP1 EGFR EGFR PKHD1 PKHD1 ACVRL1 ACVRL1 SIRT6 SIRT6 SOX9 SOX9 GRN GRN HYAL1 HYAL1 STAT5A STAT5A FGF10 FGF10 PROX1 PROX1 SHH SHH PTPRN PTPRN HTRA1 HTRA1 REG3A REG3A BMP5 BMP5 NODAL NODAL PLXNB3 PLXNB3 MYC MYC XBP1 XBP1 IRS2 IRS2 GDF2 GDF2 FGFR2 FGFR2 ADAM17 ADAM17 APELA APELA CCR3 CCR3 ARG1 ARG1 PTN PTN GPBAR1 GPBAR1 NOG NOG SCN5A SCN5A ZNF580 ZNF580 FZD7 FZD7 FGF2 FGF2 CXCL12 CXCL12 PRKD1 PRKD1 IQGAP3 IQGAP3 STXBP4 STXBP4 HTR2B HTR2B IHH IHH JAML JAML PRKD2 PRKD2 AGAP2 AGAP2 ZBED9 ZBED9 NRARP NRARP ENSCATP00000003834 ENSCATP00000003834 ATP7A ATP7A GATA2 GATA2 SP1 SP1 HMX2 HMX2 APLNR APLNR CRNN CRNN RESP18 RESP18 SOX11 SOX11 AKT1 AKT1 RPTOR RPTOR PGF PGF HIF1A HIF1A NOTCH1 NOTCH1 ERBB2 ERBB2 CDH3 CDH3 WNT3A WNT3A TNFSF12 TNFSF12 KDR KDR SAAL1 SAAL1 TGFB1 TGFB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KDM5BLysine demethylase 5B. (1501 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
NKX2-6NK2 homeobox 6. (301 aa)
CCL26C-C motif chemokine. (94 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ESRP2Epithelial splicing regulatory protein 2. (715 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
LACRTLacritin. (137 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (409 aa)
HLXH2.0 like homeobox. (494 aa)
ARAndrogen receptor. (897 aa)
SRSF6Serine and arginine rich splicing factor 6. (343 aa)
EGR3Early growth response 3. (387 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (568 aa)
NKX2-5NK2 homeobox 5. (324 aa)
TGM1Transglutaminase 1. (819 aa)
ENSCATP00000015541Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (462 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1570 aa)
TCF7L2Transcription factor 7 like 2. (666 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
THBS4Thrombospondin 4. (935 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (382 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
MYDGFMyeloid derived growth factor. (190 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
STAT3Signal transducer and activator of transcription. (777 aa)
VIPVasoactive intestinal peptide. (170 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (534 aa)
ECM1Extracellular matrix protein 1. (540 aa)
BADBCL2 associated agonist of cell death. (167 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (997 aa)
HAS2Hyaluronan synthase 2. (552 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
NME1Nucleoside diphosphate kinase. (177 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ENSCATP00000019930Nucleoside diphosphate kinase. (168 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
BTKTyrosine-protein kinase. (659 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
ZNF703Zinc finger protein 703. (591 aa)
CTNNB1Catenin beta 1. (781 aa)
HPNHepsin; Belongs to the peptidase S1 family. (421 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
REG3GRegenerating family member 3 gamma. (174 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
AREGAmphiregulin. (274 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
YAP1Yes associated protein 1. (508 aa)
ODAMOdontogenic, ameloblast associated. (279 aa)
F3Coagulation factor III, tissue factor. (296 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
DLX6Distal-less homeobox 6. (293 aa)
EPGNEpithelial mitogen. (154 aa)
JCADJunctional cadherin 5 associated. (1373 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
EMC10ER membrane protein complex subunit 10. (345 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
ZNF304Zinc finger protein 304. (703 aa)
RUNX2RUNX family transcription factor 2. (635 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
WDR48WD repeat domain 48. (679 aa)
OSR2Odd-skipped related transciption factor 2. (401 aa)
DLX5Distal-less homeobox 5. (288 aa)
HMOX1Heme oxygenase 1. (311 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
RREB1Ras responsive element binding protein 1. (1742 aa)
IGF1Insulin like growth factor 1. (208 aa)
FOXE3Forkhead box E3. (318 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
TGFATransforming growth factor alpha. (166 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
VASH2Vasohibin 2. (355 aa)
IGF2Insulin like growth factor 2. (236 aa)
HSF4Heat shock transcription factor 4. (492 aa)
SCG2Secretogranin II. (703 aa)
LAMC1Laminin subunit gamma 1. (1598 aa)
SEMA5ASemaphorin 5A. (1074 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MDKMidkine. (143 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NOTCH2Notch receptor 2. (2610 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
AGGF1Uncharacterized protein. (710 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (670 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SIRT1Sirtuin 1. (744 aa)
RTN4Reticulon. (1193 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (472 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa)
PROK1Prokineticin 1. (105 aa)
TBX1T-box transcription factor 1. (485 aa)
PAX2Paired box 2. (417 aa)
NF1Neurofibromin 1. (2839 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
BMP6Bone morphogenetic protein 6. (520 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (926 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4054 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa)
SIRT6Sirtuin 6. (355 aa)
SOX9SRY-box transcription factor 9. (509 aa)
GRNGranulin precursor. (593 aa)
HYAL1Hyaluronidase. (435 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PROX1Prospero homeobox 1. (737 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (1043 aa)
HTRA1HtrA serine peptidase 1. (481 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
NODALNodal growth differentiation factor. (347 aa)
PLXNB3Plexin B3. (1904 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
XBP1BZIP domain-containing protein. (380 aa)
IRS2Insulin receptor substrate 2. (1338 aa)
GDF2Growth differentiation factor 2. (429 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
APELAUncharacterized protein. (54 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
ARG1Arginase. (322 aa)
PTNPleiotrophin. (172 aa)
GPBAR1G protein-coupled bile acid receptor 1. (330 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
ZNF580Zinc finger protein 580. (172 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1631 aa)
STXBP4Syntaxin binding protein 4. (554 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
JAMLJunction adhesion molecule like. (394 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (881 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa)
ZBED9Zinc finger BED-type containing 9. (1325 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
ENSCATP00000003834PTN_MK_N domain-containing protein. (60 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
GATA2GATA binding protein 2. (480 aa)
SP1Sp1 transcription factor. (786 aa)
HMX2H6 family homeobox 2. (273 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
CRNNCornulin. (495 aa)
RESP18Regulated endocrine specific protein 18. (222 aa)
SOX11Transcription factor SOX. (441 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1314 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (831 aa)
NOTCH1Notch receptor 1. (2547 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (818 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (250 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
SAAL1Serum amyloid A like 1. (473 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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