70 items (Cercocebus atys) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
	ENSCATP00000000012	Protein kinase domain-containing protein. (231 aa)
	ECRG4	ECRG4 augurin precursor. (148 aa)
	SMC6	Structural maintenance of chromosomes 6. (1092 aa)
	CDKN2A	Cyclin dependent kinase inhibitor 2A. (159 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (517 aa)
	NPM1	Nucleophosmin 1. (294 aa)
	ENSCATP00000003984	Uncharacterized protein. (276 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (628 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
	MIF	Macrophage migration inhibitory factor. (115 aa)
	MNT	MAX network transcriptional repressor. (580 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1366 aa)
	MAPK11	Mitogen-activated protein kinase. (366 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	SMC5	SMC_N domain-containing protein. (1201 aa)
	PML	Promyelocytic leukemia. (882 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	BRCA2	BRCA2 DNA repair associated. (3419 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	MAP2K3	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
	PLA2R1	Phospholipase A2 receptor 1. (1466 aa)
	ENSCATP00000017239	Uncharacterized protein. (179 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	KAT6A	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2003 aa)
	SRF	Serum response factor. (508 aa)
	CALR	Calreticulin. (389 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (728 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	ENSCATP00000020360	SP-RING-type domain-containing protein. (201 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	ULK3	Unc-51 like kinase 3. (539 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (681 aa)
	CDKN2B	Cyclin dependent kinase inhibitor 2B. (138 aa)
	ENSCATP00000025668	Uncharacterized protein. (94 aa)
	ENSCATP00000026830	Uncharacterized protein. (233 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	TBX2	T-box transcription factor 2. (588 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa)
	HMGA2	High mobility group AT-hook 2. (147 aa)
	TERF2	Telomeric repeat binding factor 2. (542 aa)
	ENSCATP00000031513	Uncharacterized protein. (295 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3073 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	NSMCE2	SP-RING-type domain-containing protein. (246 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (474 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1073 aa)
	WRN	WRN RecQ like helicase. (1418 aa)
	ENSCATP00000035826	Uncharacterized protein. (286 aa)
	ENSCATP00000035908	Uncharacterized protein. (247 aa)
	SIRT1	Sirtuin 1. (744 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa)
	ENSCATP00000037667	Protein kinase domain-containing protein. (365 aa)
	LOC105575645	Nucleoplasmin domain-containing protein. (210 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	HMGA1	Uncharacterized protein. (201 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	ENSCATP00000039241	Uncharacterized protein. (287 aa)
	ENSCATP00000039328	Nucleoplasmin domain-containing protein. (209 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (224 aa)
	ENSCATP00000040578	Nucleoplasmin domain-containing protein. (217 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	PRMT6	Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
	MAPK10	Mitogen-activated protein kinase. (474 aa)
	NUP62	Nucleoporin 62. (338 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ATM	ENSCATP00000017539	ENSCATP00000032722	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.921
ABL1	CDKN1A	ENSCATP00000017539	ENSCATP00000004883	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1A.	0.585
ABL1	CDKN1B	ENSCATP00000017539	ENSCATP00000033041	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1B.	0.438
ABL1	HRAS	ENSCATP00000017539	ENSCATP00000014290	Tyrosine-protein kinase.	HRas proto-oncogene, GTPase.	0.404
ABL1	MAPK11	ENSCATP00000017539	ENSCATP00000009753	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.465
ABL1	MAPK14	ENSCATP00000017539	ENSCATP00000038594	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.482
ABL1	TP53	ENSCATP00000017539	ENSCATP00000032045	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.557
ARNTL	SIRT1	ENSCATP00000005343	ENSCATP00000036131	Aryl hydrocarbon receptor nuclear translocator like.	Sirtuin 1.	0.747
ATM	ABL1	ENSCATP00000032722	ENSCATP00000017539	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.921
ATM	BRCA2	ENSCATP00000032722	ENSCATP00000015406	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA2 DNA repair associated.	0.911
ATM	CDK2	ENSCATP00000032722	ENSCATP00000040682	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.808
ATM	KAT6A	ENSCATP00000032722	ENSCATP00000017704	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.654
ATM	MAPK10	ENSCATP00000032722	ENSCATP00000042261	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase.	0.572
ATM	MAPK8	ENSCATP00000032722	ENSCATP00000002330	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase.	0.582
ATM	MAPK9	ENSCATP00000032722	ENSCATP00000019872	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase.	0.479
ATM	SIRT1	ENSCATP00000032722	ENSCATP00000036131	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Sirtuin 1.	0.497
ATM	SMC5	ENSCATP00000032722	ENSCATP00000013599	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMC_N domain-containing protein.	0.453
ATM	TP53	ENSCATP00000032722	ENSCATP00000032045	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.996
ATM	TP63	ENSCATP00000032722	ENSCATP00000024991	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.814
ATM	WRN	ENSCATP00000032722	ENSCATP00000035398	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	WRN RecQ like helicase.	0.987