25 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

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co-expression

protein homology

Your Input:
	TNKS	Poly [ADP-ribose] polymerase. (1327 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (825 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1315 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
	GNL3L	G protein nucleolar 3 like. (582 aa)
	TENT4B	Terminal nucleotidyltransferase 4B. (676 aa)
	PML	Promyelocytic leukemia. (882 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (691 aa)
	CTC1	CST telomere replication complex component 1. (1217 aa)
	POT1	Protection of telomeres 1. (634 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
	SRC	Tyrosine-protein kinase. (644 aa)
	DCP2	Decapping mRNA 2. (420 aa)
	SLX4	SLX4 structure-specific endonuclease subunit. (1813 aa)
	TINF2	TERF1 interacting nuclear factor 2. (439 aa)
	TEN1	Uncharacterized protein. (123 aa)
	PINX1	PIN2 (TERF1) interacting telomerase inhibitor 1. (322 aa)
	XRN1	5'-3' exoribonuclease 1. (1707 aa)
	SLX1A	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (304 aa)
	MCRS1	Microspherule protein 1. (505 aa)
	EXOSC10	Exosome component 10. (884 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	TERF2	Telomeric repeat binding factor 2. (542 aa)
	NAT10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
	LOC105572009	G domain-containing protein. (489 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTC1	POT1	ENSCATP00000011191	ENSCATP00000011062	CST telomere replication complex component 1.	Protection of telomeres 1.	0.872
CTC1	TEN1	ENSCATP00000011191	ENSCATP00000042427	CST telomere replication complex component 1.	Uncharacterized protein.	0.994
CTC1	TERF1	ENSCATP00000011191	ENSCATP00000008219	CST telomere replication complex component 1.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.791
CTC1	TERF2	ENSCATP00000011191	ENSCATP00000031136	CST telomere replication complex component 1.	Telomeric repeat binding factor 2.	0.834
CTC1	TINF2	ENSCATP00000011191	ENSCATP00000043038	CST telomere replication complex component 1.	TERF1 interacting nuclear factor 2.	0.836
DCP2	EXOSC10	ENSCATP00000000084	ENSCATP00000031930	Decapping mRNA 2.	Exosome component 10.	0.509
DCP2	XRN1	ENSCATP00000000084	ENSCATP00000038205	Decapping mRNA 2.	5'-3' exoribonuclease 1.	0.993
ERCC4	PARP1	ENSCATP00000020198	ENSCATP00000031757	ERCC excision repair 4, endonuclease catalytic subunit.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.623
ERCC4	PIF1	ENSCATP00000020198	ENSCATP00000013123	ERCC excision repair 4, endonuclease catalytic subunit.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...]	0.411
ERCC4	SLX1A	ENSCATP00000020198	ENSCATP00000036115	ERCC excision repair 4, endonuclease catalytic subunit.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.	0.860
ERCC4	SLX4	ENSCATP00000020198	ENSCATP00000043699	ERCC excision repair 4, endonuclease catalytic subunit.	SLX4 structure-specific endonuclease subunit.	0.981
EXOSC10	DCP2	ENSCATP00000031930	ENSCATP00000000084	Exosome component 10.	Decapping mRNA 2.	0.509
EXOSC10	GNL3L	ENSCATP00000031930	ENSCATP00000015501	Exosome component 10.	G protein nucleolar 3 like.	0.879
EXOSC10	LOC105572009	ENSCATP00000031930	ENSCATP00000026860	Exosome component 10.	G domain-containing protein.	0.879
EXOSC10	NAT10	ENSCATP00000031930	ENSCATP00000029134	Exosome component 10.	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.	0.750
EXOSC10	TENT4B	ENSCATP00000031930	ENSCATP00000015361	Exosome component 10.	Terminal nucleotidyltransferase 4B.	0.794
EXOSC10	XRN1	ENSCATP00000031930	ENSCATP00000038205	Exosome component 10.	5'-3' exoribonuclease 1.	0.580
GNL3L	EXOSC10	ENSCATP00000015501	ENSCATP00000031930	G protein nucleolar 3 like.	Exosome component 10.	0.879
GNL3L	HNRNPU	ENSCATP00000015501	ENSCATP00000023465	G protein nucleolar 3 like.	Heterogeneous nuclear ribonucleoprotein U.	0.482
GNL3L	NAT10	ENSCATP00000015501	ENSCATP00000029134	G protein nucleolar 3 like.	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.	0.875