STRINGSTRING
GRAP2 GRAP2 NCK1 NCK1 ENSCATP00000012914 ENSCATP00000012914 CISH CISH LYN LYN SH2D1B SH2D1B GRB14 GRB14 RIN1 RIN1 GRB10 GRB10 JAK2 JAK2 HSH2D HSH2D GRAP GRAP JAK3 JAK3 SOCS6 SOCS6 SOCS4 SOCS4 SH2D2A SH2D2A ENSCATP00000006855 ENSCATP00000006855 ENSCATP00000005869 ENSCATP00000005869 SOCS5 SOCS5 RASA1 RASA1 STAT4 STAT4 LCP2 LCP2 INPP5D INPP5D SRC SRC SH2D1A SH2D1A SOCS2 SOCS2 PTPN6 PTPN6 STAT5B STAT5B SOCS1 SOCS1 CRK CRK FER FER SH2D3C SH2D3C SUPT6H SUPT6H JAK1 JAK1 STAT6 STAT6 BLNK BLNK SH2D3A SH2D3A STAT2 STAT2 TXK TXK SHC4 SHC4 CRKL CRKL DAPP1 DAPP1 CLNK CLNK FRK FRK TNS2 TNS2 STAT1 STAT1 PTK6 PTK6 SLA SLA STAT5A STAT5A ENSCATP00000031569 ENSCATP00000031569 INPPL1 INPPL1 NCK2 NCK2 ZAP70 ZAP70 TNS3 TNS3 SOCS7 SOCS7 SHB SHB MATK MATK SRMS SRMS PIK3R1 PIK3R1 PIK3R3 PIK3R3 SHC1 SHC1 YES1 YES1 CHN1 CHN1 SHD SHD VAV2 VAV2 SOCS3 SOCS3 TEC TEC SYK SYK VAV3 VAV3 STAP2 STAP2 SH2B2 SH2B2 LOC105585293 LOC105585293 BCAR3 BCAR3 SHF SHF PIK3R2 PIK3R2 SH2D5 SH2D5 BLK BLK GRB7 GRB7 SH2B3 SH2B3 RIN2 RIN2 SHC3 SHC3 GRB2 GRB2 LCK LCK FGR FGR RIN3 RIN3 BMX BMX ENSCATP00000044421 ENSCATP00000044421 FYN FYN LOC105592931 LOC105592931 ABL2 ABL2 SLA2 SLA2 PLCG1 PLCG1 TNS1 TNS1 HCK HCK BTK BTK PLCG2 PLCG2 PTPN11 PTPN11 STAP1 STAP1 SH2D4A SH2D4A VAV1 VAV1 SH3BP2 SH3BP2 SHE SHE ABL1 ABL1 STAT3 STAT3 SH2B1 SH2B1 SH2D7 SH2D7 FES FES ITK ITK CSK CSK TNS4 TNS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRAP2GRB2 related adaptor protein 2. (330 aa)
NCK1Cytoplasmic protein. (377 aa)
ENSCATP00000012914Tyrosine-protein kinase. (399 aa)
CISHCytokine inducible SH2 containing protein. (274 aa)
LYNTyrosine-protein kinase. (507 aa)
SH2D1BSH2 domain containing 1B. (132 aa)
GRB14Growth factor receptor bound protein 14. (540 aa)
RIN1Ras and Rab interactor 1. (783 aa)
GRB10Growth factor receptor bound protein 10. (593 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
HSH2DHematopoietic SH2 domain containing. (352 aa)
GRAPGRB2 related adaptor protein. (217 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
SH2D2ASH2 domain containing 2A. (371 aa)
ENSCATP00000006855Uncharacterized protein. (519 aa)
ENSCATP00000005869Uncharacterized protein. (526 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
RASA1RAS p21 protein activator 1. (1051 aa)
STAT4Signal transducer and activator of transcription. (710 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1184 aa)
SRCTyrosine-protein kinase. (644 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
SOCS2Suppressor of cytokine signaling 2. (202 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
STAT6Signal transducer and activator of transcription. (737 aa)
BLNKB cell linker. (456 aa)
SH2D3ASH2 domain containing 3A. (576 aa)
STAT2Signal transducer and activator of transcription. (852 aa)
TXKTyrosine-protein kinase. (527 aa)
SHC4SHC adaptor protein 4. (630 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
DAPP1Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (280 aa)
CLNKCytokine dependent hematopoietic cell linker. (428 aa)
FRKTyrosine-protein kinase. (505 aa)
TNS2Tensin 2. (1419 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
PTK6Tyrosine-protein kinase. (507 aa)
SLASrc like adaptor. (293 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
ENSCATP00000031569Chimaerin; GTPase-activating protein for p21-rac. (441 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1258 aa)
NCK2Cytoplasmic protein. (382 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
TNS3Tensin 3. (1553 aa)
SOCS7Suppressor of cytokine signaling 7. (644 aa)
SHBSH2 domain containing adaptor protein B. (509 aa)
MATKTyrosine-protein kinase. (591 aa)
SRMSTyrosine-protein kinase. (492 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
SHC1SHC adaptor protein 1. (584 aa)
YES1Tyrosine-protein kinase. (543 aa)
CHN1Chimaerin; GTPase-activating protein for p21-rac. (459 aa)
SHDSrc homology 2 domain containing transforming protein D. (340 aa)
VAV2Vav guanine nucleotide exchange factor 2. (868 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
TECTyrosine-protein kinase. (630 aa)
SYKNon-specific protein-tyrosine kinase. (637 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
STAP2Signal transducing adaptor family member 2. (391 aa)
SH2B2SH2B adaptor protein 2. (678 aa)
LOC105585293Uncharacterized protein. (290 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (825 aa)
SHFSrc homology 2 domain containing F. (424 aa)
PIK3R2Uncharacterized protein. (624 aa)
SH2D5SH2 domain containing 5. (427 aa)
BLKTyrosine-protein kinase. (505 aa)
GRB7Growth factor receptor bound protein 7. (558 aa)
SH2B3SH2B adaptor protein 3. (660 aa)
RIN2Ras and Rab interactor 2. (895 aa)
SHC3SHC adaptor protein 3. (598 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LCKTyrosine-protein kinase. (540 aa)
FGRTyrosine-protein kinase. (496 aa)
RIN3Ras and Rab interactor 3. (982 aa)
BMXTyrosine-protein kinase. (679 aa)
ENSCATP00000044421Uncharacterized protein. (441 aa)
FYNTyrosine-protein kinase. (537 aa)
LOC105592931Uncharacterized protein. (457 aa)
ABL2Tyrosine-protein kinase. (1172 aa)
SLA2Src like adaptor 2. (261 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
TNS1Tensin 1. (1740 aa)
HCKTyrosine-protein kinase. (504 aa)
BTKTyrosine-protein kinase. (659 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
SH2D4ASH2 domain containing 4A. (454 aa)
VAV1Vav guanine nucleotide exchange factor 1. (856 aa)
SH3BP2SH3 domain binding protein 2. (605 aa)
SHESrc homology 2 domain containing E. (495 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
STAT3Signal transducer and activator of transcription. (777 aa)
SH2B1SH2B adaptor protein 1. (756 aa)
SH2D7SH2 domain containing 7. (456 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (856 aa)
ITKTyrosine-protein kinase. (620 aa)
CSKTyrosine-protein kinase. (450 aa)
TNS4Tensin 4. (716 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.