STRINGSTRING
NEK1 NEK1 MLKL MLKL RIPK2 RIPK2 ENSCATP00000040664 ENSCATP00000040664 MET MET FGFR1 FGFR1 ERBB4 ERBB4 ACVR1 ACVR1 NTRK1 NTRK1 MAP3K7 MAP3K7 STYK1 STYK1 LCK LCK NEK6 NEK6 FGR FGR KSR2 KSR2 TESK2 TESK2 BMX BMX PDGFRB PDGFRB GUCY2F GUCY2F RYK RYK LTK LTK TNK2 TNK2 EPHB4 EPHB4 BLK BLK DDR1 DDR1 FLT4 FLT4 EPHA5 EPHA5 EPHA1 EPHA1 RAF1 RAF1 AATK AATK IRAK4 IRAK4 EPHA3 EPHA3 RET RET ERBB2 ERBB2 NEK7 NEK7 JAK2 JAK2 KDR KDR IGF1R IGF1R NPR1 NPR1 INSRR INSRR ENSCATP00000010452 ENSCATP00000010452 BMPR1B BMPR1B LIMK2 LIMK2 ERBB3 ERBB3 MAP3K9 MAP3K9 LYN LYN AXL AXL EPHA2 EPHA2 ARAF ARAF ENSCATP00000012914 ENSCATP00000012914 CSK CSK ITK ITK NPR2 NPR2 FES FES ENSCATP00000016044 ENSCATP00000016044 NTRK3 NTRK3 ROR1 ROR1 EPHA8 EPHA8 TNNI3K TNNI3K EPHA10 EPHA10 TYRO3 TYRO3 ABL1 ABL1 RIPK1 RIPK1 PTK2B PTK2B GUCY2C GUCY2C BMPR1A BMPR1A TEK TEK FGFR3 FGFR3 BTK BTK ROR2 ROR2 YES1 YES1 LMTK2 LMTK2 EPHB6 EPHB6 PTK7 PTK7 SRMS SRMS INSR INSR MATK MATK EPHB2 EPHB2 FGFR2 FGFR2 MAP3K13 MAP3K13 DSTYK DSTYK FGFR4 FGFR4 LMTK3 LMTK3 TYK2 TYK2 KIT KIT POMK POMK EPHB1 EPHB1 CSF1R CSF1R TEC TEC SYK SYK TIE1 TIE1 TESK1 TESK1 GUCY2D GUCY2D FLT3 FLT3 SRC SRC EPHA6 EPHA6 MST1R MST1R PTK2 PTK2 EPHA7 EPHA7 PDGFRA PDGFRA DDR2 DDR2 ANKK1 ANKK1 ROS1 ROS1 MAP3K21 MAP3K21 JAK3 JAK3 KSR1 KSR1 MAP3K12 MAP3K12 ZAP70 ZAP70 ENSCATP00000030673 ENSCATP00000030673 EPHA4 EPHA4 MAP3K20 MAP3K20 PTK6 PTK6 EPHB3 EPHB3 ACVRL1 ACVRL1 FRK FRK EGFR EGFR TXK TXK TGFBR2 TGFBR2 NTRK2 NTRK2 TEX14 TEX14 HCK HCK BRAF BRAF FLT1 FLT1 NRBP1 NRBP1 LIMK1 LIMK1 MUSK MUSK ABL2 ABL2 MERTK MERTK ENSCATP00000023350 ENSCATP00000023350 FYN FYN ALK ALK JAK1 JAK1 TNK1 TNK1 MAP3K10 MAP3K10 MAP3K11 MAP3K11 ILK ILK FER FER
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NEK1NIMA related kinase 1. (1295 aa)
MLKLMixed lineage kinase domain like pseudokinase. (477 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
ENSCATP00000040664Uncharacterized protein. (558 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (586 aa)
STYK1Serine/threonine/tyrosine kinase 1. (422 aa)
LCKTyrosine-protein kinase. (540 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (347 aa)
FGRTyrosine-protein kinase. (496 aa)
KSR2Kinase suppressor of ras 2. (912 aa)
TESK2Testis associated actin remodelling kinase 2. (572 aa)
BMXTyrosine-protein kinase. (679 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
GUCY2FGuanylate cyclase. (1108 aa)
RYKReceptor like tyrosine kinase. (613 aa)
LTKTyrosine-protein kinase receptor. (864 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1042 aa)
EPHB4EPH receptor B4. (987 aa)
BLKTyrosine-protein kinase. (505 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (986 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
EPHA5EPH receptor A5. (1038 aa)
EPHA1EPH receptor A1. (976 aa)
RAF1Uncharacterized protein. (668 aa)
AATKApoptosis associated tyrosine kinase. (1470 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
EPHA3EPH receptor A3. (984 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1115 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
JAK2Tyrosine-protein kinase. (1137 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
NPR1Guanylate cyclase. (1061 aa)
INSRRTyrosine-protein kinase receptor. (1296 aa)
ENSCATP00000010452Uncharacterized protein. (596 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LIMK2LIM domain kinase 2. (638 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1349 aa)
MAP3K9Mitogen-activated protein kinase kinase kinase 9. (1116 aa)
LYNTyrosine-protein kinase. (507 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
EPHA2EPH receptor A2. (1033 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
ENSCATP00000012914Tyrosine-protein kinase. (399 aa)
CSKTyrosine-protein kinase. (450 aa)
ITKTyrosine-protein kinase. (620 aa)
NPR2Guanylate cyclase. (1047 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (856 aa)
ENSCATP00000016044Protein kinase domain-containing protein. (357 aa)
NTRK3Tyrosine-protein kinase receptor. (866 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
EPHA8EPH receptor A8. (1000 aa)
TNNI3KUncharacterized protein. (835 aa)
EPHA10EPH receptor A10. (1014 aa)
TYRO3TYRO3 protein tyrosine kinase. (890 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
GUCY2CGuanylate cyclase. (1073 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
BTKTyrosine-protein kinase. (659 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
YES1Tyrosine-protein kinase. (543 aa)
LMTK2Lemur tyrosine kinase 2. (1501 aa)
EPHB6EPH receptor B6. (1017 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
SRMSTyrosine-protein kinase. (492 aa)
INSRTyrosine-protein kinase receptor. (1339 aa)
MATKTyrosine-protein kinase. (591 aa)
EPHB2EPH receptor B2. (1085 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (931 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
LMTK3Lemur tyrosine kinase 3. (1509 aa)
TYK2Tyrosine-protein kinase. (1164 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
POMKProtein O-mannose kinase. (360 aa)
EPHB1EPH receptor B1. (984 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
TECTyrosine-protein kinase. (630 aa)
SYKNon-specific protein-tyrosine kinase. (637 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
TESK1Testis associated actin remodelling kinase 1. (626 aa)
GUCY2DGuanylate cyclase. (1103 aa)
FLT3Fms related tyrosine kinase 3. (741 aa)
SRCTyrosine-protein kinase. (644 aa)
EPHA6EPH receptor A6. (1130 aa)
MST1RMacrophage stimulating 1 receptor. (1426 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1068 aa)
EPHA7EPH receptor A7. (998 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1024 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (873 aa)
ANKK1Ankyrin repeat and kinase domain containing 1. (735 aa)
ROS1Tyrosine-protein kinase receptor. (2345 aa)
MAP3K21Mitogen-activated protein kinase kinase kinase. (1040 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
KSR1Kinase suppressor of ras 1. (932 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (890 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
ENSCATP00000030673Uncharacterized protein. (652 aa)
EPHA4EPH receptor A4. (986 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (788 aa)
PTK6Tyrosine-protein kinase. (507 aa)
EPHB3EPH receptor B3. (1008 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa)
FRKTyrosine-protein kinase. (505 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
TXKTyrosine-protein kinase. (527 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
TEX14Testis expressed 14, intercellular bridge forming factor. (1497 aa)
HCKTyrosine-protein kinase. (504 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
NRBP1Nuclear receptor binding protein 1. (543 aa)
LIMK1LIM domain kinase 1. (672 aa)
MUSKMuscle associated receptor tyrosine kinase. (881 aa)
ABL2Tyrosine-protein kinase. (1172 aa)
MERTKMER proto-oncogene, tyrosine kinase. (954 aa)
ENSCATP00000023350Uncharacterized protein. (730 aa)
FYNTyrosine-protein kinase. (537 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
TNK1Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (661 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (952 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
ILKIntegrin linked kinase. (526 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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