(18 nodes) Furin-like repeat network (Cercocebus atys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRELD1	Cysteine rich with EGF like domains 1. (420 aa)
	PCSK4	Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (755 aa)
	RSPO3	R-spondin 3. (293 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	FRAS1	Fraser extracellular matrix complex subunit 1. (4012 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	RSPO1	R-spondin 1. (262 aa)
	RSPO4	R-spondin 4. (234 aa)
	PCSK5	Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1860 aa)
	RSPO2	R-spondin 2. (243 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1349 aa)
	INSRR	Tyrosine-protein kinase receptor. (1296 aa)
	CRELD2	Cysteine rich with EGF like domains 2. (401 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1366 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1399 aa)
	INSR	Tyrosine-protein kinase receptor. (1339 aa)
	PCSK6	Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (934 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB2	ENSCATP00000033478	ENSCATP00000008001	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.997
EGFR	ERBB3	ENSCATP00000033478	ENSCATP00000010580	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.985
EGFR	ERBB4	ENSCATP00000033478	ENSCATP00000041332	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.957
EGFR	IGF1R	ENSCATP00000033478	ENSCATP00000009142	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.955
EGFR	INSR	ENSCATP00000033478	ENSCATP00000007816	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.802
EGFR	INSRR	ENSCATP00000033478	ENSCATP00000010255	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.594
ERBB2	EGFR	ENSCATP00000008001	ENSCATP00000033478	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.997
ERBB2	ERBB3	ENSCATP00000008001	ENSCATP00000010580	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.995
ERBB2	ERBB4	ENSCATP00000008001	ENSCATP00000041332	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.989
ERBB2	IGF1R	ENSCATP00000008001	ENSCATP00000009142	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.963
ERBB2	INSR	ENSCATP00000008001	ENSCATP00000007816	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.848
ERBB2	INSRR	ENSCATP00000008001	ENSCATP00000010255	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.679
ERBB3	EGFR	ENSCATP00000010580	ENSCATP00000033478	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.985
ERBB3	ERBB2	ENSCATP00000010580	ENSCATP00000008001	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.995
ERBB3	ERBB4	ENSCATP00000010580	ENSCATP00000041332	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.916
ERBB3	IGF1R	ENSCATP00000010580	ENSCATP00000009142	Erb-b2 receptor tyrosine kinase 3.	Tyrosine-protein kinase receptor.	0.630
ERBB4	EGFR	ENSCATP00000041332	ENSCATP00000033478	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.957
ERBB4	ERBB2	ENSCATP00000041332	ENSCATP00000008001	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.989
ERBB4	ERBB3	ENSCATP00000041332	ENSCATP00000010580	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.916
ERBB4	IGF1R	ENSCATP00000041332	ENSCATP00000009142	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.508