15 items (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3660 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
	ATR	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2573 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
	PIK3C2G	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1486 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PI4KA	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2072 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	PI4KB	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (739 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3073 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSCATP00000032722	ENSCATP00000021242	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.995
ATM	MTOR	ENSCATP00000032722	ENSCATP00000035789	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.532
ATM	PRKDC	ENSCATP00000032722	ENSCATP00000023124	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.815
ATM	SMG1	ENSCATP00000032722	ENSCATP00000031183	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.617
ATR	ATM	ENSCATP00000021242	ENSCATP00000032722	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.995
ATR	MTOR	ENSCATP00000021242	ENSCATP00000035789	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.415
MTOR	ATM	ENSCATP00000035789	ENSCATP00000032722	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.532
MTOR	ATR	ENSCATP00000035789	ENSCATP00000021242	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.415
MTOR	PI4KA	ENSCATP00000035789	ENSCATP00000037808	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	0.522
MTOR	PI4KB	ENSCATP00000035789	ENSCATP00000033289	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	0.488
MTOR	PIK3C3	ENSCATP00000035789	ENSCATP00000038559	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.568
MTOR	PIK3CA	ENSCATP00000035789	ENSCATP00000027089	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.925
MTOR	PIK3CB	ENSCATP00000035789	ENSCATP00000024233	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.925
MTOR	PIK3CD	ENSCATP00000035789	ENSCATP00000038140	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.925
MTOR	PIK3CG	ENSCATP00000035789	ENSCATP00000034511	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.647
PI4KA	MTOR	ENSCATP00000037808	ENSCATP00000035789	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.522
PI4KA	PI4KB	ENSCATP00000037808	ENSCATP00000033289	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	0.963
PI4KA	PIK3C2A	ENSCATP00000037808	ENSCATP00000002668	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family.	0.887
PI4KA	PIK3C2B	ENSCATP00000037808	ENSCATP00000024322	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	0.894
PI4KA	PIK3C2G	ENSCATP00000037808	ENSCATP00000042785	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family.	0.902