STRINGSTRING
MSH4 MSH4 TEX15 TEX15 LOC105572651 LOC105572651 LOC105572650 LOC105572650 SUN1 SUN1 ENSCATP00000002663 ENSCATP00000002663 CDK2 CDK2 LOC105574041 LOC105574041 FAM9C FAM9C IZUMO3 IZUMO3 CD9 CD9 ENSCATP00000038940 ENSCATP00000038940 MND1 MND1 SPO11 SPO11 SUN2 SUN2 SYCE2 SYCE2 SYNE1 SYNE1 TEX12 TEX12 SYCP3 SYCP3 ENSCATP00000036401 ENSCATP00000036401 MRE11 MRE11 LOC105599742 LOC105599742 TMEM238 TMEM238 MLH1 MLH1 SMC1B SMC1B BLM BLM CATSPER2 CATSPER2 B4GALT1 B4GALT1 RAD51C RAD51C ENSCATP00000034029 ENSCATP00000034029 CATSPERD CATSPERD FKBP6 FKBP6 ATM ATM LOC105593797 LOC105593797 SYCP1 SYCP1 HVCN1 HVCN1 TERF2 TERF2 SMC1A SMC1A SYCE3 SYCE3 REC8 REC8 UBE2I UBE2I TERF2IP TERF2IP H3F3B H3F3B ENSCATP00000029485 ENSCATP00000029485 OVGP1 OVGP1 MLH3 MLH3 HSPA2 HSPA2 CATSPER1 CATSPER1 SPAG4 SPAG4 ADAM2 ADAM2 IZUMO4 IZUMO4 IZUMO1 IZUMO1 FAM9B FAM9B DMC1 DMC1 CATSPERG CATSPERG H2AC6 H2AC6 LOC105572669 LOC105572669 H2AZ2 H2AZ2 LOC105572652 LOC105572652 H3C6 H3C6 H2BC5 H2BC5 LOC105572666 LOC105572666 SYCP2 SYCP2 LOC105592904 LOC105592904 LOC105572655 LOC105572655 RBBP8 RBBP8 LOC105572658 LOC105572658 LOC105572638 LOC105572638 H2BC1 H2BC1 ENSCATP00000000344 ENSCATP00000000344 ENSCATP00000026626 ENSCATP00000026626 KCNT2 KCNT2 SUN3 SUN3 ENSCATP00000025894 ENSCATP00000025894 H3F3A H3F3A ENSCATP00000025399 ENSCATP00000025399 STAG1 STAG1 STAG3 STAG3 H2BC3 H2BC3 ENSCATP00000023311 ENSCATP00000023311 TPRX1 TPRX1 RAD21 RAD21 MSH5 MSH5 LMNB1 LMNB1 ENSCATP00000022608 ENSCATP00000022608 ENSCATP00000022164 ENSCATP00000022164 ENSCATP00000004608 ENSCATP00000004608 LOC105597697 LOC105597697 LOC105593174 LOC105593174 LOC105593169 LOC105593169 H2AC4 H2AC4 ENSCATP00000005102 ENSCATP00000005102 H2AC20 H2AC20 H4C11 H4C11 FAM9A FAM9A CDK4 CDK4 LOC105593167 LOC105593167 H2AX H2AX H3C13 H3C13 H2BC11 H2BC11 H2BC21 H2BC21 TERF1 TERF1 ZP4 ZP4 CATSPER4 CATSPER4 ZP3 ZP3 RPA3 RPA3 IZUMO2 IZUMO2 SYNE2 SYNE2 STAG2 STAG2 ENSCATP00000010958 ENSCATP00000010958 POT1 POT1 SUN5 SUN5 ENSCATP00000012945 ENSCATP00000012945 H2BC15 H2BC15 BRCA2 BRCA2 CATSPERB CATSPERB LOC105590811 LOC105590811 DIDO1 DIDO1 NBN NBN ADAM18 ADAM18 SPAM1 SPAM1 ADAM32 ADAM32 LMNA LMNA KCNU1 KCNU1 RAD51 RAD51 ENSCATP00000019755 ENSCATP00000019755 SYCE1 SYCE1 LOC105572092 LOC105572092 ZP1 ZP1 ATR ATR LOC105590810 LOC105590810 LOC105571810 LOC105571810 CATSPER3 CATSPER3 BRCA1 BRCA1 TOP3A TOP3A PSMC3IP PSMC3IP SMC3 SMC3 TINF2 TINF2 ACR ACR LOC105575319 LOC105575319 H2BC7 H2BC7 ENSCATP00000004425 ENSCATP00000004425 LOC105572665 LOC105572665 H3-4 H3-4 LOC105593194 LOC105593194 LOC105585120 LOC105585120 SYCP2L SYCP2L H2AJ H2AJ LOC105572671 LOC105572671 H2BC8 H2BC8 LOC105572676 LOC105572676
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSH4MutS homolog 4. (935 aa)
TEX15Testis expressed 15, meiosis and synapsis associated. (3181 aa)
LOC105572651Histone H4. (103 aa)
LOC105572650Histone H3.1. (136 aa)
SUN1Sad1 and UNC84 domain containing 1. (932 aa)
ENSCATP00000002663annotation not available (136 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
LOC105574041Uncharacterized protein. (732 aa)
FAM9CFamily with sequence similarity 9 member C. (166 aa)
IZUMO3IZUMO family member 3. (239 aa)
CD9Tetraspanin. (228 aa)
ENSCATP00000038940Uncharacterized protein. (566 aa)
MND1Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (205 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (396 aa)
SUN2Sad1 and UNC84 domain containing 2. (728 aa)
SYCE2Synaptonemal complex central element protein 2. (218 aa)
SYNE1Spectrin repeat containing nuclear envelope protein 1. (8797 aa)
TEX12Testis expressed 12. (123 aa)
SYCP3Cor1 domain-containing protein. (236 aa)
ENSCATP00000036401Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
LOC105599742Zinc-hook domain-containing protein. (1192 aa)
TMEM238Transmembrane protein 238. (162 aa)
MLH1MutL homolog 1. (756 aa)
SMC1BStructural maintenance of chromosomes protein. (1235 aa)
BLMBLM RecQ like helicase. (1416 aa)
CATSPER2Cation channel sperm associated 2. (530 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
RAD51CRAD51 paralog C. (367 aa)
ENSCATP00000034029Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (581 aa)
CATSPERDCation channel sperm associated auxiliary subunit delta. (728 aa)
FKBP6Peptidylprolyl isomerase. (327 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3073 aa)
LOC105593797Uncharacterized protein. (775 aa)
SYCP1Synaptonemal complex protein 1. (976 aa)
HVCN1Hydrogen voltage gated channel 1. (273 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
SYCE3Synaptonemal complex central element protein 3. (88 aa)
REC8REC8 meiotic recombination protein. (549 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (237 aa)
TERF2IPTERF2 interacting protein. (400 aa)
H3F3BH3 histone, family 3B. (136 aa)
ENSCATP00000029485Histone H2A; Belongs to the histone H2A family. (117 aa)
OVGP1Oviductal glycoprotein 1; Belongs to the glycosyl hydrolase 18 family. (662 aa)
MLH3MutL homolog 3. (1436 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (602 aa)
CATSPER1Cation channel sperm associated 1. (769 aa)
SPAG4Sperm associated antigen 4. (440 aa)
ADAM2ADAM metallopeptidase domain 2. (740 aa)
IZUMO4IZUMO family member 4. (219 aa)
IZUMO1Izumo sperm-egg fusion 1. (350 aa)
FAM9BFamily with sequence similarity 9 member B. (226 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (319 aa)
CATSPERGCation channel sperm associated auxiliary subunit gamma. (1159 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC105572669Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC105572652Histone H4. (103 aa)
H3C6Histone H3.1. (136 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105572666Histone H4. (103 aa)
SYCP2Synaptonemal complex protein 2. (1530 aa)
LOC105592904Histone H3; Belongs to the histone H3 family. (136 aa)
LOC105572655Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
RBBP8RB binding protein 8, endonuclease. (905 aa)
LOC105572658Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105572638Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
ENSCATP00000000344Histone H3; Belongs to the histone H3 family. (136 aa)
ENSCATP00000026626Uncharacterized protein. (160 aa)
KCNT2Potassium sodium-activated channel subfamily T member 2. (1135 aa)
SUN3Sad1 and UNC84 domain containing 3. (362 aa)
ENSCATP00000025894Histone H2A; Belongs to the histone H2A family. (115 aa)
H3F3AH3 histone, family 3A. (136 aa)
ENSCATP00000025399Histone H2B; Belongs to the histone H2B family. (134 aa)
STAG1Stromal antigen 1. (1291 aa)
STAG3Stromal antigen 3. (1268 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSCATP00000023311Histone H2A; Belongs to the histone H2A family. (92 aa)
TPRX1Tetrapeptide repeat homeobox 1. (444 aa)
RAD21RAD21 cohesin complex component. (631 aa)
MSH5DNA_MISMATCH_REPAIR_2 domain-containing protein. (834 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (586 aa)
ENSCATP00000022608Uncharacterized protein. (490 aa)
ENSCATP00000022164Histone H2A; Belongs to the histone H2A family. (113 aa)
ENSCATP00000004608annotation not available (136 aa)
LOC105597697Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105593174Histone H4. (103 aa)
LOC105593169Histone H3.1. (136 aa)
H2AC4Histone H2A type 1. (130 aa)
ENSCATP00000005102annotation not available (136 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
H4C11Histone H4. (103 aa)
FAM9AFamily with sequence similarity 9 member A. (286 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
LOC105593167Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
H3C13Histone H3. (136 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
ZP4Zona pellucida glycoprotein 4. (539 aa)
CATSPER4Cation channel sperm associated 4. (484 aa)
ZP3ZP domain-containing protein. (424 aa)
RPA3Replication protein A3. (121 aa)
IZUMO2IZUMO family member 2. (221 aa)
SYNE2Spectrin repeat containing nuclear envelope protein 2. (6907 aa)
STAG2Stromal antigen 2. (1268 aa)
ENSCATP00000010958Histone H3; Belongs to the histone H3 family. (141 aa)
POT1Protection of telomeres 1. (634 aa)
SUN5Sad1 and UNC84 domain containing 5. (379 aa)
ENSCATP00000012945Protein kinase domain-containing protein. (101 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
CATSPERBCation channel sperm associated auxiliary subunit beta. (1115 aa)
LOC105590811Uncharacterized protein. (753 aa)
DIDO1Death inducer-obliterator 1. (2236 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
ADAM18ADAM metallopeptidase domain 18. (691 aa)
SPAM1Hyaluronidase. (512 aa)
ADAM32ADAM metallopeptidase domain 32. (790 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (728 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (1151 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (309 aa)
ENSCATP00000019755Rad21_Rec8 domain-containing protein. (141 aa)
SYCE1Synaptonemal complex central element protein 1. (328 aa)
LOC105572092Histone H2A; Belongs to the histone H2A family. (182 aa)
ZP1Zona pellucida glycoprotein 1. (635 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2573 aa)
LOC105590810Uncharacterized protein. (728 aa)
LOC105571810Cor1 domain-containing protein. (221 aa)
CATSPER3Cation channel sperm associated 3. (398 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1871 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (994 aa)
PSMC3IPPSMC3 interacting protein. (217 aa)
SMC3Structural maintenance of chromosomes 3. (1007 aa)
TINF2TERF1 interacting nuclear factor 2. (439 aa)
ACRAcrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (419 aa)
LOC105575319Uncharacterized protein. (553 aa)
H2BC7Histone H2B type 1. (126 aa)
ENSCATP00000004425annotation not available (136 aa)
LOC105572665Histone H4. (103 aa)
H3-4Histone cluster 3 H3. (136 aa)
LOC105593194Histone H4. (103 aa)
LOC105585120Histone H4. (103 aa)
SYCP2LSynaptonemal complex protein 2 like. (787 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
LOC105572671Histone H4. (103 aa)
H2BC8Histone H2B type 1. (126 aa)
LOC105572676Histone H4. (103 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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