Your Input: | |
| | ENSCATP00000000117 | Uncharacterized protein. (93 aa) |
| | H2AZ2 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | ENSCATP00000000344 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | LOC105572638 | Histone domain-containing protein; Belongs to the histone H2B family. (127 aa) |
| | DLK1 | Delta like non-canonical Notch ligand 1. (383 aa) |
| | LOC105572658 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105572655 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC105592904 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | HEY1 | Hes related family bHLH transcription factor with YRPW motif 1. (304 aa) |
| | LOC105572666 | Histone H4. (103 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H3C6 | Histone H3.1. (136 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (429 aa) |
| | LOC105572652 | Histone H4. (103 aa) |
| | TBL1X | Transducin beta like 1 X-linked. (573 aa) |
| | LOC105572669 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H2AC6 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | ENSCATP00000002663 | annotation not available (136 aa) |
| | DTX2 | Deltex E3 ubiquitin ligase 2. (622 aa) |
| | PSMA7 | Proteasome subunit alpha type. (248 aa) |
| | LOC105572650 | Histone H3.1. (136 aa) |
| | RAB6A | RAB6A, member RAS oncogene family. (208 aa) |
| | LOC105572651 | Histone H4. (103 aa) |
| | ENSCATP00000003364 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCATP00000003394 | Transcription factor. (393 aa) |
| | LOC105572676 | Histone H4. (103 aa) |
| | ENSCATP00000003644 | ANK_REP_REGION domain-containing protein. (116 aa) |
| | H2BC8 | Histone H2B type 1. (126 aa) |
| | ATP2A1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1012 aa) |
| | LOC105572671 | Histone H4. (103 aa) |
| | H2AJ | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | ENSCATP00000003834 | PTN_MK_N domain-containing protein. (60 aa) |
| | LOC105585120 | Histone H4. (103 aa) |
| | ITCH | E3 ubiquitin-protein ligase. (862 aa) |
| | PSMA1 | Proteasome subunit alpha type. (269 aa) |
| | LOC105593194 | Histone H4. (103 aa) |
| | MFNG | Beta-1,3-N-acetylglucosaminyltransferase. (321 aa) |
| | LOC105572665 | Histone H4. (103 aa) |
| | PTCRA | Pre T cell antigen receptor alpha. (281 aa) |
| | PLXND1 | Plexin D1. (1925 aa) |
| | ENSCATP00000037470 | AAA domain-containing protein. (389 aa) |
| | ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (333 aa) |
| | PSMB6 | Proteasome subunit beta. (285 aa) |
| | ENSCATP00000037714 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (232 aa) |
| | POFUT1 | Protein O-fucosyltransferase 1. (388 aa) |
| | ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6; Belongs to the glycosyltransferase 29 family. (371 aa) |
| | DTX4 | Deltex E3 ubiquitin ligase 4. (619 aa) |
| | NOTCH2 | Notch receptor 2. (2610 aa) |
| | PSMA4 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (307 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa) |
| | ENSCATP00000004425 | annotation not available (136 aa) |
| | NUMB | NUMB endocytic adaptor protein. (652 aa) |
| | ENSCATP00000038535 | E2F_CC-MB domain-containing protein. (193 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (379 aa) |
| | NCOR2 | Nuclear receptor corepressor 2. (2510 aa) |
| | MDK | Midkine. (143 aa) |
| | TFDP1 | Transcription factor. (417 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (315 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | ENSCATP00000040310 | ANK_REP_REGION domain-containing protein. (159 aa) |
| | CCNC | Cyclin C; Belongs to the cyclin family. (283 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (166 aa) |
| | HDAC6 | Histone deacetylase 6. (1217 aa) |
| | ENSCATP00000041490 | AAA domain-containing protein; Belongs to the AAA ATPase family. (199 aa) |
| | AGO4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | NOTCH3 | Notch receptor 3. (2321 aa) |
| | KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa) |
| | PSME3 | Proteasome activator subunit 3. (265 aa) |
| | EP300 | E1A binding protein p300. (2411 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa) |
| | HDAC7 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1017 aa) |
| | PSMB5 | Proteasome subunit beta. (263 aa) |
| | RBPJ | Recombination signal binding protein for immunoglobulin kappa J region. (488 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | PSMD5 | Proteasome 26S subunit, non-ATPase 5. (508 aa) |
| | FURIN | Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa) |
| | SNW1 | SNW domain containing 1. (598 aa) |
| | ENSCATP00000043644 | Ubiquitin-like domain-containing protein. (120 aa) |
| | ST3GAL3 | ST3 beta-galactoside alpha-2,3-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (444 aa) |
| | PSME2 | Proteasome activator subunit 2. (239 aa) |
| | PBX3 | PBX homeobox 3. (434 aa) |
| | DTX1 | Deltex E3 ubiquitin ligase 1. (622 aa) |
| | H2BC7 | Histone H2B type 1. (126 aa) |
| | ENSCATP00000004608 | annotation not available (136 aa) |
| | LOC105597697 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | YBX1 | CSD_1 domain-containing protein. (324 aa) |
| | LOC105593174 | Histone H4. (103 aa) |
| | LOC105593169 | Histone H3.1. (136 aa) |
| | PSMF1 | Proteasome inhibitor subunit 1. (271 aa) |
| | ENSCATP00000004934 | ATPase_AAA_core domain-containing protein; Belongs to the AAA ATPase family. (177 aa) |
| | H2AC4 | Histone H2A type 1. (130 aa) |
| | ENSCATP00000005102 | annotation not available (136 aa) |
| | H2AC20 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | H4C11 | Histone H4. (103 aa) |
| | LOC105593167 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | H3C13 | Histone H3. (136 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | JAG2 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1162 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | PSMC3 | AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105579396 | Ubiquitin-like domain-containing protein. (156 aa) |
| | CDK8 | Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa) |
| | LOC105595668 | Ubiquitin-like domain-containing protein. (126 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (831 aa) |
| | LFNG | Beta-1,3-N-acetylglucosaminyltransferase. (379 aa) |
| | NOTCH1 | Notch receptor 1. (2547 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (324 aa) |
| | YWHAZ | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa) |
| | PSMB8 | Proteasome subunit beta. (276 aa) |
| | HDAC11 | Histone deacetylase 11. (347 aa) |
| | PBX2 | PBX homeobox 2. (430 aa) |
| | HDAC10 | Histone deacetylase 10. (671 aa) |
| | TLE4 | TLE family member 4, transcriptional corepressor. (801 aa) |
| | WWP2 | E3 ubiquitin-protein ligase. (870 aa) |
| | TACC3 | Transforming acidic coiled-coil containing protein 3. (817 aa) |
| | MAMLD1 | Mastermind like domain containing 1. (1003 aa) |
| | HES4 | Hes family bHLH transcription factor 4. (221 aa) |
| | TNRC6B | Trinucleotide repeat containing adaptor 6B. (1823 aa) |
| | MIB1 | Mindbomb E3 ubiquitin protein ligase 1. (1006 aa) |
| | IKZF2 | IKAROS family zinc finger 2. (526 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | ENSCATP00000010732 | CSN8_PSD8_EIF3K domain-containing protein. (249 aa) |
| | ENSCATP00000010958 | Histone H3; Belongs to the histone H3 family. (141 aa) |
| | AGO3 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa) |
| | WWC1 | WW and C2 domain containing 1. (1119 aa) |
| | FCER2 | Fc fragment of IgE receptor II. (321 aa) |
| | ENSCATP00000011745 | AAA domain-containing protein. (410 aa) |
| | ENSCATP00000011971 | Uncharacterized protein. (191 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (442 aa) |
| | FABP7 | Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) |
| | NBEA | Neurobeachin. (2946 aa) |
| | CRB1 | Crumbs cell polarity complex component 1. (1394 aa) |
| | PSMD4 | Proteasome 26S subunit, non-ATPase 4. (363 aa) |
| | PSMC6 | AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa) |
| | DNER | Delta/notch like EGF repeat containing. (667 aa) |
| | ENSCATP00000013881 | GOLD domain-containing protein. (188 aa) |
| | HDAC8 | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (415 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (166 aa) |
| | APH1B | Aph-1 homolog B, gamma-secretase subunit. (257 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (778 aa) |
| | PBX1 | PBX homeobox 1. (430 aa) |
| | ENSCATP00000014541 | Prot_ATP_ID_OB domain-containing protein. (172 aa) |
| | ENSCATP00000014620 | SKIP_SNW domain-containing protein. (480 aa) |
| | AGO1 | Argonaute RISC component 1; Belongs to the argonaute family. (858 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | ENSCATP00000015253 | AAA domain-containing protein. (373 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1038 aa) |
| | ENSCATP00000016334 | Uncharacterized protein. (338 aa) |
| | IKZF4 | IKAROS family zinc finger 4. (585 aa) |
| | ENSCATP00000016481 | AAA domain-containing protein. (370 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | IKZF3 | IKAROS family zinc finger 3. (509 aa) |
| | LOC105579883 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (238 aa) |
| | NCOR1 | Nuclear receptor corepressor 1. (2442 aa) |
| | PSMB10 | Proteasome subunit beta. (273 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (456 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | MIB2 | Mindbomb E3 ubiquitin protein ligase 2. (1070 aa) |
| | ENSCATP00000019150 | CSD_1 domain-containing protein. (291 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | ENSCATP00000020004 | Uncharacterized protein; Belongs to the SKP1 family. (198 aa) |
| | ENSCATP00000020093 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (433 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | ENSCATP00000020357 | AAA domain-containing protein; Belongs to the AAA ATPase family. (414 aa) |
| | TLE1 | TLE family member 1, transcriptional corepressor. (770 aa) |
| | PSMC5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa) |
| | APH1A | Aph-1 homolog A, gamma-secretase subunit. (265 aa) |
| | TBL1XR1 | Transducin beta like 1 X-linked receptor 1. (514 aa) |
| | LOC105572092 | Histone H2A; Belongs to the histone H2A family. (182 aa) |
| | ENSCATP00000021172 | Uncharacterized protein. (278 aa) |
| | PSME1 | Proteasome activator subunit 1. (249 aa) |
| | HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1129 aa) |
| | MAML2 | Mastermind like transcriptional coactivator 2. (1151 aa) |
| | ATP2A2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa) |
| | PSMD9 | PDZ domain-containing protein. (223 aa) |
| | ENSCATP00000022164 | Histone H2A; Belongs to the histone H2A family. (113 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (326 aa) |
| | HEY2 | Hes related family bHLH transcription factor with YRPW motif 2. (337 aa) |
| | TLE2 | TLE family member 2, transcriptional corepressor. (732 aa) |
| | ENSCATP00000023311 | Histone H2A; Belongs to the histone H2A family. (92 aa) |
| | PBX4 | PBX homeobox 4. (377 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa) |
| | ENSCATP00000023795 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (238 aa) |
| | EHF | ETS homologous factor. (322 aa) |
| | TFDP2 | Transcription factor. (446 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa) |
| | MAML1 | Mastermind like transcriptional coactivator 1. (963 aa) |
| | ELF3 | E74 like ETS transcription factor 3. (371 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | ENSCATP00000025399 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | H3F3A | H3 histone, family 3A. (136 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | NCSTN | Nicastrin. (721 aa) |
| | ENSCATP00000025894 | Histone H2A; Belongs to the histone H2A family. (115 aa) |
| | MOV10 | Mov10 RISC complex RNA helicase. (1003 aa) |
| | LRBA | LPS responsive beige-like anchor protein. (2852 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | GZMB | Granzyme B; Belongs to the peptidase S1 family. (281 aa) |
| | ADAM17 | ADAM metallopeptidase domain 17. (824 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | HDAC9 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa) |
| | CNTN1 | Contactin 1. (843 aa) |
| | RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (312 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (350 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | PSMA6 | Proteasome subunit alpha type. (246 aa) |
| | DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (713 aa) |
| | TMED2 | Transmembrane p24 trafficking protein 2. (208 aa) |
| | PSENEN | Presenilin enhancer, gamma-secretase subunit. (101 aa) |
| | HEYL | Hes related family bHLH transcription factor with YRPW motif like. (328 aa) |
| | ENSCATP00000029485 | Histone H2A; Belongs to the histone H2A family. (117 aa) |
| | H3F3B | H3 histone, family 3B. (136 aa) |
| | ENSCATP00000030060 | Uncharacterized protein. (281 aa) |
| | NEURL1B | Neuralized E3 ubiquitin protein ligase 1B. (554 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa) |
| | ENSCATP00000031033 | Ubiquitin-like domain-containing protein. (149 aa) |
| | NOTCH4 | Notch receptor 4. (2000 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa) |
| | POGLUT1 | Protein O-glucosyltransferase 1. (392 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | AGO2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (859 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (274 aa) |
| | STAT1 | Signal transducer and activator of transcription. (780 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | SIRT6 | Sirtuin 6. (355 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (465 aa) |
| | ARRB1 | Arrestin beta 1. (418 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | E2F3 | E2F transcription factor 3. (467 aa) |
| | DLGAP5 | DLG associated protein 5. (851 aa) |
| | B4GALT1 | Beta-1,4-galactosyltransferase 1. (398 aa) |
| | FBXW7 | F-box and WD repeat domain containing 7. (707 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | ENSCATP00000034742 | JAB_MPN domain-containing protein. (166 aa) |
| | ENSCATP00000034768 | Ubiquitin-like domain-containing protein. (144 aa) |
| | ENSCATP00000035052 | Uncharacterized protein. (211 aa) |
| | ENSCATP00000035134 | Ubiquitin-like domain-containing protein. (146 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa) |
| | RUNX1 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | NEURL1 | Neuralized E3 ubiquitin protein ligase 1. (574 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (534 aa) |
| | ADAM10 | ADAM metallopeptidase domain 10. (748 aa) |
| | IKZF1 | IKAROS family zinc finger 1. (519 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa) |
| | SEL1L | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (793 aa) |
