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| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa) |
| | ENSCATP00000020493 | Uncharacterized protein. (150 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1056 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (556 aa) |
| | DKC1 | Dyskerin pseudouridine synthase 1. (514 aa) |
| | TRUB1 | TruB pseudouridine synthase family member 1. (350 aa) |
| | ENSCATP00000015553 | Histone H2B; Belongs to the histone H2B family. (129 aa) |
| | ANKRD28 | Ankyrin repeat domain 28. (1059 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa) |
| | PPP6C | Serine/threonine-protein phosphatase. (338 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (166 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | LOC105572652 | Histone H4. (103 aa) |
| | LOC105572669 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H2AC6 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | LOC105572651 | Histone H4. (103 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105572676 | Histone H4. (103 aa) |
| | RFC5 | Replication factor C subunit 5. (343 aa) |
| | H2BC8 | Histone H2B type 1. (126 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | LOC105572671 | Histone H4. (103 aa) |
| | H2AJ | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1352 aa) |
| | LOC105572092 | Histone H2A; Belongs to the histone H2A family. (182 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | POLR2H | RNA polymerase II subunit H. (169 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (1003 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (439 aa) |
| | TEN1 | Uncharacterized protein. (123 aa) |
| | NHP2 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa) |
| | POLD3 | Uncharacterized protein. (466 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | LIG1 | DNA ligase. (918 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | POLR2L | RNA polymerase II subunit L. (67 aa) |
| | SHQ1 | SHQ1, H/ACA ribonucleoprotein assembly factor. (577 aa) |
| | POLR2F | RNA polymerase II subunit F. (158 aa) |
| | ENSCATP00000036401 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | POLR2C | RNA polymerase II subunit C. (275 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | BLM | BLM RecQ like helicase. (1416 aa) |
| | WRN | WRN RecQ like helicase. (1418 aa) |
| | ANKRD66 | Ankyrin repeat domain 66. (250 aa) |
| | H2AZ2 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | LOC105572638 | Histone domain-containing protein; Belongs to the histone H2B family. (127 aa) |
| | LOC105572658 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105572655 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | POLR2K | RNA polymerase II subunit K. (58 aa) |
| | POLA1 | DNA polymerase. (1469 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | TERF2 | Telomeric repeat binding factor 2. (542 aa) |
| | TERF2IP | TERF2 interacting protein. (400 aa) |
| | H3F3B | H3 histone, family 3B. (136 aa) |
| | ENSCATP00000029485 | Histone H2A; Belongs to the histone H2A family. (117 aa) |
| | ENSCATP00000029353 | Uncharacterized protein. (77 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (549 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (465 aa) |
| | POLR2B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa) |
| | PPP6R3 | Protein phosphatase 6 regulatory subunit 3. (879 aa) |
| | DAXX | Death domain associated protein. (739 aa) |
| | POLR2D | RNA polymerase II subunit D. (142 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1123 aa) |
| | ENSCATP00000026110 | Uncharacterized protein. (222 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (620 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (691 aa) |
| | POLR2G | RNA polymerase II subunit G. (244 aa) |
| | ENSCATP00000021744 | Uncharacterized protein. (68 aa) |
| | ENSCATP00000022164 | Histone H2A; Belongs to the histone H2A family. (113 aa) |
| | ENSCATP00000023311 | Histone H2A; Belongs to the histone H2A family. (92 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | LOC105593170 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (101 aa) |
| | POLR2E | RNA polymerase II subunit E. (210 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ANKRD44 | Ankyrin repeat domain 44. (1004 aa) |
| | LOC105572666 | Histone H4. (103 aa) |
| | H2BW1 | H2B histone family member W, testis specific; Belongs to the histone H2B family. (175 aa) |
| | ENSCATP00000025399 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | H3F3A | H3 histone, family 3A. (136 aa) |
| | ENSCATP00000025894 | Histone H2A; Belongs to the histone H2A family. (115 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | PPP6R2 | Protein phosphatase 6 regulatory subunit 2. (958 aa) |
| | RFC4 | Replication factor C subunit 4. (349 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | CTC1 | CST telomere replication complex component 1. (1217 aa) |
| | POT1 | Protection of telomeres 1. (634 aa) |
| | ENSCATP00000010958 | Histone H3; Belongs to the histone H3 family. (141 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (374 aa) |
| | ENSCATP00000010284 | Uncharacterized protein. (164 aa) |
| | LOC105585120 | Histone H4. (103 aa) |
| | LOC105593194 | Histone H4. (103 aa) |
| | H3-4 | Histone cluster 3 H3. (136 aa) |
| | POLR2A | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1970 aa) |
| | LOC105572665 | Histone H4. (103 aa) |
| | RFC1 | Replication factor C subunit 1. (1113 aa) |
| | NOP10 | NOP10 ribonucleoprotein. (64 aa) |
| | H2BC7 | Histone H2B type 1. (126 aa) |
| | LOC105597697 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105593174 | Histone H4. (103 aa) |
| | H2AC4 | Histone H2A type 1. (130 aa) |
| | H2AC20 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | H4C11 | Histone H4. (103 aa) |
| | POLR2I | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | LOC105593167 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105593172 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (218 aa) |
| | LOC105593181 | Histone H2B type 1-M. (126 aa) |
