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| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1044 aa) |
| | LOC105572183 | Uncharacterized protein. (3228 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | NLRP13 | NLR family pyrin domain containing 13. (1044 aa) |
| | BPIFC | BPI fold containing family C. (507 aa) |
| | ENSCATP00000017436 | ETS domain-containing protein. (394 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa) |
| | ELK1 | ETS domain-containing protein. (428 aa) |
| | NLRP9 | NLR family pyrin domain containing 9. (992 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (403 aa) |
| | NKIRAS1 | NFKB inhibitor interacting Ras like 1. (192 aa) |
| | CCDC71L | Coiled-coil domain containing 71 like. (235 aa) |
| | USP14 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (486 aa) |
| | MEF2A | Myocyte enhancer factor 2A. (504 aa) |
| | ENSCATP00000004013 | Uncharacterized protein. (711 aa) |
| | ENSCATP00000007830 | Uncharacterized protein. (436 aa) |
| | ENSCATP00000008212 | Uncharacterized protein. (145 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | APOB | Apolipoprotein B. (4495 aa) |
| | UBE2NL | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa) |
| | ENSCATP00000004894 | ETS domain-containing protein. (421 aa) |
| | HMGB1 | High mobility group box 1. (215 aa) |
| | ATF7 | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa) |
| | HSP90B1 | Heat shock protein 90 beta family member 1. (804 aa) |
| | SARM1 | Sterile alpha and TIR motif containing 1. (724 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (571 aa) |
| | ENSCATP00000005869 | Uncharacterized protein. (526 aa) |
| | TLR1 | Toll-like receptor. (786 aa) |
| | LOC105576738 | Ubiquitin-like domain-containing protein. (134 aa) |
| | CD180 | CD180 molecule. (661 aa) |
| | TLR10 | Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa) |
| | UNC93A | Unc-93 homolog A. (457 aa) |
| | LOC105579396 | Ubiquitin-like domain-containing protein. (156 aa) |
| | LOC105595668 | Ubiquitin-like domain-containing protein. (126 aa) |
| | TLR2 | Toll-like receptor. (784 aa) |
| | TICAM2 | Toll like receptor adaptor molecule 2. (235 aa) |
| | KHNYN | KH and NYN domain containing. (678 aa) |
| | FGA | Fibrinogen alpha chain. (863 aa) |
| | LRRC31 | Leucine rich repeat containing 31. (552 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa) |
| | VRK3 | VRK serine/threonine kinase 3. (451 aa) |
| | ENSCATP00000011808 | Ubiquitin-like domain-containing protein. (130 aa) |
| | SIGIRR | Single Ig and TIR domain containing. (488 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (758 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (374 aa) |
| | LOC105583935 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa) |
| | ENSCATP00000013712 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa) |
| | GSDMB | Gasdermin B. (370 aa) |
| | PTPN4 | Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (926 aa) |
| | PELI2 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa) |
| | FGB | Fibrinogen beta chain. (491 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | DUSP7 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (596 aa) |
| | ATF1 | Activating transcription factor 1. (270 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (625 aa) |
| | LOC105585327 | WRNPLPNID domain-containing protein. (954 aa) |
| | PELI3 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa) |
| | TIRAP | TIR domain containing adaptor protein. (239 aa) |
| | LBP | Lipopolysaccharide binding protein. (481 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | ENSCATP00000014838 | ETS domain-containing protein. (418 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | IRF7 | Interferon regulatory factor 7. (517 aa) |
| | DUSP4 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa) |
| | BPI | Bactericidal permeability increasing protein. (511 aa) |
| | LOC105598875 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa) |
| | ECSIT | ECSIT signalling integrator. (432 aa) |
| | CTSS | Cathepsin S; Belongs to the peptidase C1 family. (331 aa) |
| | CTSK | Cathepsin K; Belongs to the peptidase C1 family. (329 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (732 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1390 aa) |
| | CREM | cAMP responsive element modulator. (330 aa) |
| | N4BP1 | NEDD4 binding protein 1. (896 aa) |
| | CTSB | Cathepsin B; Belongs to the peptidase C1 family. (339 aa) |
| | SFTPD | Surfactant protein D. (375 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (515 aa) |
| | ENSCATP00000027386 | Uncharacterized protein. (109 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | GSDME | Gasdermin E. (495 aa) |
| | UNC93B1 | Unc-93 homolog B1, TLR signaling regulator. (597 aa) |
| | CTSV | Cathepsin V; Belongs to the peptidase C1 family. (334 aa) |
| | S100B | S_100 domain-containing protein; Belongs to the S-100 family. (94 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (519 aa) |
| | LY86 | Lymphocyte antigen 86. (162 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (344 aa) |
| | PIK3R4 | Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa) |
| | RPS6KA5 | Non-specific serine/threonine protein kinase. (896 aa) |
| | FNBP4 | Formin binding protein 4. (1017 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | ENSCATP00000031033 | Ubiquitin-like domain-containing protein. (149 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (1044 aa) |
| | FGG | Fibrinogen gamma chain. (453 aa) |
| | DNM3 | Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa) |
| | ALPK1 | Alpha kinase 1. (1244 aa) |
| | DNM2 | Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (788 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | LRRC14 | Leucine rich repeat containing 14. (493 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (618 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | GSDMD | Gasdermin D. (532 aa) |
| | FOSL2 | FOS like 2, AP-1 transcription factor subunit. (326 aa) |
| | ITGB2 | Integrin beta. (870 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa) |
| | LRRC45 | Leucine rich repeat containing 45. (670 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (589 aa) |
| | DUSP3 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa) |
| | IRF3 | Interferon regulatory factor 3. (422 aa) |
| | ENSCATP00000034500 | Uncharacterized protein. (464 aa) |
| | ENSCATP00000034768 | Ubiquitin-like domain-containing protein. (144 aa) |
| | ENSCATP00000035134 | Ubiquitin-like domain-containing protein. (146 aa) |
| | PPP4R4 | Protein phosphatase 4 regulatory subunit 4. (872 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (550 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | S100A1 | Protein S100; Belongs to the S-100 family. (147 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (483 aa) |
| | TNIP2 | CCHC NOA-type domain-containing protein. (346 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (517 aa) |
| | LRRC71 | Leucine rich repeat containing 71. (559 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1508 aa) |
| | NLRC5 | NLR family CARD domain containing 5. (1774 aa) |
| | DUSP6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (416 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa) |
| | ENSCATP00000037667 | Protein kinase domain-containing protein. (365 aa) |
| | S100A9 | Protein S100; Belongs to the S-100 family. (114 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (544 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | LRRC34 | Leucine rich repeat containing 34. (464 aa) |
| | S100A8 | Protein S100; Belongs to the S-100 family. (93 aa) |
| | LOC105587074 | Uncharacterized protein. (186 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) |
| | APP | Amyloid beta precursor protein. (770 aa) |
| | LOC105597804 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (132 aa) |
| | TLR9 | TIR domain-containing protein. (1033 aa) |
| | LGMN | Legumain. (433 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | LOC105598099 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | CNPY4 | Canopy FGF signaling regulator 4. (244 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa) |
| | LOC105598876 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | LRRC74A | Leucine rich repeat containing 74A. (488 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa) |
| | TLR7 | Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (586 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (721 aa) |
| | TLR8 | Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa) |
| | NKIRAS2 | NFKB inhibitor interacting Ras like 2. (198 aa) |
| | ENSCATP00000043644 | Ubiquitin-like domain-containing protein. (120 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | NLRX1 | NLR family member X1. (794 aa) |
| | ENSCATP00000044421 | Uncharacterized protein. (441 aa) |
| | CTSL | Cathepsin L; Belongs to the peptidase C1 family. (333 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | S100A12 | S100 calcium binding protein A12; Belongs to the S-100 family. (90 aa) |
| | EEA1 | Early endosome antigen 1. (1411 aa) |
| | LY96 | Lymphocyte antigen 96. (160 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (572 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | PPP4R1 | Protein phosphatase 4 regulatory subunit 1. (907 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (667 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | RBSN | Rabenosyn, RAB effector. (785 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (213 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | LOC105581053 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (325 aa) |
| | CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) |
| | NAIP | NLR family apoptosis inhibitory protein. (1403 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (148 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | LOC105572338 | C-type lectin domain-containing protein. (177 aa) |
| | ENSCATP00000001061 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa) |
| | ENSCATP00000000678 | Uncharacterized protein. (211 aa) |
| | TIFA | TRAF interacting protein with forkhead associated domain. (185 aa) |
| | ENSCATP00000000464 | CCHC NOA-type domain-containing protein. (363 aa) |
| | FBXW11 | F-box and WD repeat domain containing 11. (563 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | ENSCATP00000000012 | Protein kinase domain-containing protein. (231 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1236 aa) |
| | ENSCATP00000020004 | Uncharacterized protein; Belongs to the SKP1 family. (198 aa) |
| | LOC105572345 | C-type lectin domain-containing protein. (231 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | TANK | TRAF family member associated NFKB activator. (425 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (900 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa) |
| | PTPN11 | Protein tyrosine phosphatase non-receptor type 11. (552 aa) |
| | LOC105598877 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa) |
| | MAPKAPK3 | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (411 aa) |
| | CNPY3 | Canopy FGF signaling regulator 3. (277 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
