STRINGSTRING
POLD2 POLD2 WRN WRN TERF2 TERF2 TERF2IP TERF2IP POLD4 POLD4 DNA2 DNA2 PCNA PCNA POLD1 POLD1 POT1 POT1 RPA3 RPA3 TERF1 TERF1 FEN1 FEN1 TINF2 TINF2 POLD3 POLD3 ENSCATP00000036401 ENSCATP00000036401
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
WRNWRN RecQ like helicase. (1418 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
TERF2IPTERF2 interacting protein. (400 aa)
POLD4Uncharacterized protein. (107 aa)
DNA2DNA replication helicase/nuclease 2. (1056 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POLD1DNA polymerase. (1107 aa)
POT1Protection of telomeres 1. (634 aa)
RPA3Replication protein A3. (121 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
TINF2TERF1 interacting nuclear factor 2. (439 aa)
POLD3Uncharacterized protein. (466 aa)
ENSCATP00000036401Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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