STRINGSTRING
CDK3 CDK3 POLD4 POLD4 POLA1 POLA1 CHTF18 CHTF18 TINF2 TINF2 TEN1 TEN1 NHP2 NHP2 POLD3 POLD3 STN1 STN1 CDK2 CDK2 LIG1 LIG1 RCBTB1 RCBTB1 ANKRD44 ANKRD44 ENSCATP00000020493 ENSCATP00000020493 DNA2 DNA2 RCBTB2 RCBTB2 DKC1 DKC1 TRUB1 TRUB1 ANKRD28 ANKRD28 CHTF8 CHTF8 PRIM1 PRIM1 PPP6C PPP6C PCNA PCNA RECQL4 RECQL4 PIF1 PIF1 RUVBL1 RUVBL1 EXD2 EXD2 RFC2 RFC2 PPP6R2 PPP6R2 RFC4 RFC4 POLD1 POLD1 CTC1 CTC1 POT1 POT1 CCNA2 CCNA2 DSCC1 DSCC1 RPA3 RPA3 TERF1 TERF1 GAR1 GAR1 POLA2 POLA2 NOP10 NOP10 RFC1 RFC1 RTEL1 RTEL1 MEIOB MEIOB RFC5 RFC5 RFC3 RFC3 FEN1 FEN1 ENSCATP00000026110 ENSCATP00000026110 TERT TERT PPP6R3 PPP6R3 RUVBL2 RUVBL2 WRAP53 WRAP53 ENSCATP00000029353 ENSCATP00000029353 TERF2IP TERF2IP TERF2 TERF2 CCNA1 CCNA1 POLD2 POLD2 BLM BLM WRN WRN ANKRD66 ANKRD66 SHQ1 SHQ1 ENSCATP00000036401 ENSCATP00000036401
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
POLD4Uncharacterized protein. (107 aa)
POLA1DNA polymerase. (1469 aa)
CHTF18Chromosome transmission fidelity factor 18. (1003 aa)
TINF2TERF1 interacting nuclear factor 2. (439 aa)
TEN1Uncharacterized protein. (123 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
POLD3Uncharacterized protein. (466 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
LIG1DNA ligase. (918 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
ANKRD44Ankyrin repeat domain 44. (1004 aa)
ENSCATP00000020493Uncharacterized protein. (150 aa)
DNA2DNA replication helicase/nuclease 2. (1056 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
DKC1Dyskerin pseudouridine synthase 1. (514 aa)
TRUB1TruB pseudouridine synthase family member 1. (350 aa)
ANKRD28Ankyrin repeat domain 28. (1059 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
PPP6CSerine/threonine-protein phosphatase. (338 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RECQL4RecQ like helicase 4. (1208 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (691 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
EXD2Exonuclease 3'-5' domain containing 2. (620 aa)
RFC2Replication factor C subunit 2. (352 aa)
PPP6R2Protein phosphatase 6 regulatory subunit 2. (958 aa)
RFC4Replication factor C subunit 4. (349 aa)
POLD1DNA polymerase. (1107 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
POT1Protection of telomeres 1. (634 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (374 aa)
RPA3Replication protein A3. (121 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (218 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
RFC1Replication factor C subunit 1. (1113 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1352 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
RFC5Replication factor C subunit 5. (343 aa)
RFC3Replication factor C subunit 3. (356 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
ENSCATP00000026110Uncharacterized protein. (222 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1123 aa)
PPP6R3Protein phosphatase 6 regulatory subunit 3. (879 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (465 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
ENSCATP00000029353Uncharacterized protein. (77 aa)
TERF2IPTERF2 interacting protein. (400 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
BLMBLM RecQ like helicase. (1416 aa)
WRNWRN RecQ like helicase. (1418 aa)
ANKRD66Ankyrin repeat domain 66. (250 aa)
SHQ1SHQ1, H/ACA ribonucleoprotein assembly factor. (577 aa)
ENSCATP00000036401Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (262 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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