STRINGSTRING
PTPN11 PTPN11 PDGFRB PDGFRB ENSCATP00000044421 ENSCATP00000044421 FNDC3A FNDC3A GRB2 GRB2 PDGFB PDGFB GRB7 GRB7 CRK CRK NRAS NRAS STAT6 STAT6 CRKL CRKL STAT1 STAT1 STAT5A STAT5A NCK2 NCK2 BCAR1 BCAR1 PIK3R1 PIK3R1 CSDE1 CSDE1 PIK3CA PIK3CA PIK3CB PIK3CB PIK3R2 PIK3R2 PLCG1 PLCG1 CASS4 CASS4 STAT3 STAT3 HRAS HRAS NCK1 NCK1 KRAS KRAS NEDD9 NEDD9 RAPGEF1 RAPGEF1 PDGFRA PDGFRA ENSCATP00000005869 ENSCATP00000005869 FNDC3B FNDC3B RASA1 RASA1 ERAS ERAS SRC SRC SOS1 SOS1 EFS EFS STAT5B STAT5B PDGFA PDGFA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ENSCATP00000044421Uncharacterized protein. (441 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
GRB7Growth factor receptor bound protein 7. (558 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
STAT6Signal transducer and activator of transcription. (737 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
NCK2Cytoplasmic protein. (382 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3R2Uncharacterized protein. (624 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
STAT3Signal transducer and activator of transcription. (777 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NCK1Cytoplasmic protein. (377 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1303 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1024 aa)
ENSCATP00000005869Uncharacterized protein. (526 aa)
FNDC3BFibronectin type III domain containing 3B. (1158 aa)
RASA1RAS p21 protein activator 1. (1051 aa)
ERASES cell expressed Ras. (233 aa)
SRCTyrosine-protein kinase. (644 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
EFSEmbryonal Fyn-associated substrate. (561 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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